Grammatical Morphology in School-Age Children With and Without Language Impairment: A Discriminant Function Analysis

Purpose: The purpose of this study was to test Bedore and Leonard\u27s (1998) proposal that a verb morpheme composite may hold promise as a clinical marker for specific language impairment (SLI) in English speakers and serve as an accurate basis for the classification of children with and without SLI beyond the preschool level. Method: The language transcripts of 50 school-age children with SLI (Mage = 7;9 [years;months]) and 50 age-matched typically developing peers (Mage = 7;9) were analyzed. Following the Bedore and Leonard (1998) procedure, 3 variables were measured: a finite verb morpheme composite, a noun morpheme composite, and mean length of utterance in morphemes (MLUm). Results: Overall findings indicated that neither grammatical morpheme composite alone adequately discriminated the groups at this developmental level. However, combining the verb and noun grammatical morpheme composite measures with MLUm resulted in good discriminant accuracy in classifying subgroups of the youngest children with and without SLI in the school-age sample. Conclusion: Verb morphology alone is not a useful clinical marker of SLI in school-age children. Potential explanations for these findings and ideas for future research are discussed

Grammatical Morphology in School-Age Children With and Without Language Impairment: A Discriminant Function Analysis

Purpose: The purpose of this study was to test Bedore and Leonard\u27s (1998) proposal that a verb morpheme composite may hold promise as a clinical marker for specific language impairment (SLI) in English speakers and serve as an accurate basis for the classification of children with and without SLI beyond the preschool level. Method: The language transcripts of 50 school-age children with SLI (Mage = 7;9 [years;months]) and 50 age-matched typically developing peers (Mage = 7;9) were analyzed. Following the Bedore and Leonard (1998) procedure, 3 variables were measured: a finite verb morpheme composite, a noun morpheme composite, and mean length of utterance in morphemes (MLUm). Results: Overall findings indicated that neither grammatical morpheme composite alone adequately discriminated the groups at this developmental level. However, combining the verb and noun grammatical morpheme composite measures with MLUm resulted in good discriminant accuracy in classifying subgroups of the youngest children with and without SLI in the school-age sample. Conclusion: Verb morphology alone is not a useful clinical marker of SLI in school-age children. Potential explanations for these findings and ideas for future research are discussed

Feasibility of Manual Teach-and-Replay and Continuous Impedance Shaping for Robotic Locomotor Training Following Spinal Cord Injury

Robotic gait training is an emerging technique for retraining walking ability following spinal cord injury (SCI). A key challenge in this training is determining an appropriate stepping trajectory and level of assistance for each patient, since patients have a wide range of sizes and impairment levels. Here, we demonstrate how a lightweight yet powerful robot can record subject-specific, trainer-induced leg trajectories during manually assisted stepping, then immediately replay those trajectories. Replay of the subject-specific trajectories reduced the effort required by the trainer during manual assistance, yet still generated similar patterns of muscle activation for six subjects with a chronic SCI. We also demonstrate how the impedance of the robot can be adjusted on a step-by-step basis with an error-based, learning law. This impedance-shaping algorithm adapted the robot's impedance so that the robot assisted only in the regions of the step trajectory where the subject consistently exhibited errors. The result was that the subjects stepped with greater variability, while still maintaining a physiologic gait pattern. These results are further steps toward tailoring robotic gait training to the needs of individual patients

Kentucky Anabaptists' Knowledge of Newborn Screening

The Plain Anabaptist population in Kentucky is growing, with the Amish population alone expected to double about every 20 years. Anabaptists in Kentucky are largely composed of Amish (both Old Order and New Order) and Old Order and Conservative Mennonites. All Anabaptists experience an increased incidence of recessive genetic disorders. Newborn screening (NBS) is a state-regulated program that identifies inherited and congenital disorders and conditions. The purpose of this study is to determine the knowledge of Kentucky Amish and Mennonite communities regarding NBS. A researcher-adapted questionnaire was mailed to Kentucky Amish and Mennonite households, and 292 respondents returned the questionnaire. The majority (85.2%) reported at least "a little" knowledge of NBS; however, only 6.8% reported "a lot" of knowledge. Respondents identified the midwife as the most common source of information related to NBS; however, 18% reported NBS was not offered by any provider. There was a statistically significant relationship between knowledge of NBS and children receiving NBS, indicating that knowledge of NBS increased participation in NBS. As the midwife is the most common source of NBS knowledge, an educational program for midwives as well as the Anabaptist communities throughout Kentucky is planned

Population Pharmacokinetic and Pharmacodynamic Analysis of Buprenorphine for the Treatment of Neonatal Abstinence Syndrome

Neonatal abstinence syndrome (NAS) is a condition affecting newborns exposed to an opioid in utero. Symptoms of NAS include excessive crying, poor feeding, and disordered autonomic control. Up to 2/3 of infants will require pharmacologic therapies to reach symptom control. Opioids including morphine and methadone are the current first-line treatments. Buprenorphine is being investigated as a treatment of NAS. The purpose of this analysis was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of BUP in infants with NAS. Poster presented at American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2017 Annual Meeting, March 15-18, 2017 in Washington DC.https://jdc.jefferson.edu/petposters/1004/thumbnail.jp

Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?

A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases

‘It’s not what it looks like. I’m Santa’: connecting community through film

The lived experiences of young people are becoming increasingly marginalised within the narrowly defined curricula of neoliberal contexts. Many young people are also cast within the media according to deficit discourses of youth, which contributes to the fragmentation of communities and the limitation of interaction between generations. This article describes a film project in which young people living in an ex-mining community in the Midlands of England worked in and with their community to create a representation of where they live. As part of the process, the young filmmakers did more than connect to other people’s memories as repositories of information; both as process and as product, their film can be seen to connect shared narratives of people and place, across time and space. We argue that this project offers a timely opportunity to reflect upon the ways in which we understand learning in and out of English classrooms

Long-Billed Curlew (\u3ci\u3eNumenius americanus\u3c/i\u3e) Rangewide Survey and Monitoring Guidelines

LBCUs are a species of special concern throughout much of their breeding range in North America, with both the U.S. and Canadian Shorebird Plans listing them as “Highly Imperiled” (Brown et al. 2001). LBCUs are also listed in the U.S. as a Bird of Conservation Concern, at the National level, within FWS Regions 1, 2, 4 and 6, and for many Bird Conservation Regions (U.S. Fish and Wildlife Service 2002). This level of concern is due to apparent population declines, particularly in the shortgrass and mixed-grass prairie of the western Great Plains (Brown et al. 2001). Threats include habitat loss and fragmentation due to agricultural conversion (cropland and tame pasture), encroachment of woody vegetation, and urban development. For details on LBCU ecology, management, and conservation, refer to Dugger and Dugger (2002)

Site specific genetic incorporation of azidophenylalanine in Schizosaccharomyces pombe

The diversity of protein functions is impacted in significant part by the chemical properties of the twenty amino acids, which are used as building blocks for nearly all proteins. The ability to incorporate unnatural amino acids (UAA) into proteins in a site specific manner can vastly expand the repertoire of protein functions and also allows detailed analysis of protein function. In recent years UAAs have been incorporated in a site-specific manner into proteins in a number of organisms. In nearly all cases, the amber codon is used as a sense codon, and an orthogonal tRNA/aminoacyl-tRNA synthetase (RS) pair is used to generate amber suppressing tRNAs charged with the UAA. In this work, we have developed tools to incorporate the cross-linking amino acid azido-phenylalanine (AzF) through the use of bacterial tRNATyr and a modified version of TyrRS, AzFRS, in Schizosaccharomyces pombe, which is an attractive model organism for the study of cell behavior and function. We have incorporated AzF into three different proteins. We show that the majority of AzF is modified to amino-phenyl alanine, but protein cross-linking was still observed. These studies set the stage for exploitation of this new technology for the analysis of S. pombe proteins