(RS)-2-(3,4-Methylenedioxyphenyl)-5-phenyl-3,6-dihydro-2H-pyran

The title compound, C18H16O3, crystallizes with one molecule in the asymmetric unit. The conformation of the dihydropyran ring features puckering of the O atom by 0.612 (2) Å from the least-squares plane defined by the five C atoms [maximum deviation 0.1025 (12) Å]

Using legume-based mixtures to enhance the nitrogen use efficiency and economic viability of cropping systems - Final report (LK09106/HGCA3447)

As costs for mineral fertilisers rise, legume-based leys are recognised as a potential alternative nitrogen source for crops. Here we demonstrate that including species-rich legume-based leys in rotations helps to maximise synergies between agricultural productivity and other ecosystem services. By using functionally diverse plant species mixtures, these services can be optimised and fine-tuned to regional and farm-specific needs. Replicated field experiments were conducted over three years at multiple locations, testing the performance of 12 legume species and 4 grass species sown in monocultures, as well as in a mixture of 10 of the legumes and all 4 grasses (called the All Species Mix, ASM). In addition, we compared this complex mixture to farmer-chosen ley mixtures on 34 sites across the UK. The trials showed that there is a large degree of functional complementarity among the legume species. No single species scored high on all evaluation criteria. In particular, the currently most frequently used species, white clover, is outscored by other legume species on a number of parameters such as early development and resistance to decomposition. Further complementarity emerged from the different responses of legume species to environmental variables, with soil pH and grazing or cutting regime being among the more important factors. For example, while large birdsfoot trefoil showed better performance on more acidic soils, the opposite was true for sainfoin, lucerne and black medic. In comparison with the monocultures, the ASM showed increased ground cover, increased above-ground biomass and reduced weed biomass. Benefits of mixing species with regard to productivity increased over time. In addition, the stability of biomass production across sites was greater in the ASM than in the legume monocultures. Within the on-farm trials, we further found that on soils low in organic matter the biomass advantage of the ASM over the Control ley was more marked than on the soils with higher organic matter content. Ecological modelling revealed that the three best multifunctional mixtures all contained black medic, lucerne and red clover. Within the long term New Farming Systems (NFS) rotational study, the use of a clover bi-crop showed improvement to soil characteristics compared to current practice (e.g. bulk density and water infiltration rate). Improvements in wheat yield were also noted with respect to the inclusion of a clover bi-crop in 2010, but there was evidence of a decline in response as the N dose was increased. Cumulatively, over both the wheat crop and the spring oilseed rape crop, the clover bi-crop improved margin over N. The highest average yield response (~9%) was associated with the ASM legume species mix cover cropping approach

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially expressed genes (DEGs). In this study we demonstrate that (1) such discordance may stem from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion, the lists become much more reproducible, especially when fewer genes are selected; and (3) the instability of short DEG lists based on P cutoffs is an expected mathematical consequence of the high variability of the t-values. We recommend the use of FC ranking plus a non-stringent P cutoff as a baseline practice in order to generate more reproducible DEG lists. The FC criterion enhances reproducibility while the P criterion balances sensitivity and specificity

‘I found out the hard way’: Micro-political workings in professional football

This paper examines the micro-political experiences of Adam (a pseudonym), a newly appointed fitness coach at a Football Association Premier League Club, in his search for acceptance by senior colleagues. Data were collected through a series of in-depth, semi-structured interviews, before being subject to a process of inductive analysis. Goffman’s (1959, 1963) writings on impression management and stigma, Ball’s (1987) micro-political perspective, and Garfinkel’s (1967) notion of status degradation are primarily utilised to make sense of Adam’s perceptions and actions. The findings point to the value of developing coaches’ micro-political understandings, and of including their formal facilitation within given professional preparation programmes. Doing so, it is argued, would better equip coaches for the problematic realities of their practice

Bottom-Line Choices: Effects of Market Ideology in Florida’s Voluntary Preschool Policies

The purpose of this paper is to uncover systems of reasoning and taken-for-granted assumptions embedded within Florida’s Voluntary Preschool Education Program (VPK) policies and their implications on matters of social justice. Systems of reasoning based upon market ideology and assumptions of good economic actors, resulting from influences of conservative modernism, are identified and found to facilitate policies failing to ensure children’s constitutional right to “high quality pre-kindergarten” (Florida Constitution [Fla. Const.] art. IX, § 1(b), 2002). The authors argue that these policies intensify exclusion through institutionalized problematizing of students and act to perpetuate discriminatory and unjust practices of schooling, in this case at the preschool level. Florida’s constitution, statutes, regulations, and other government documents are analyzed to provide insight into the systems of reasoning and taken-for-granted assumptions embedded within VPK policies. Influences from conservative modernism are identified during negotiations in policy development, issues of access within the program’s choice discourses are examined, and mechanisms for exclusion embedded in these policies revealing institutional problematizing practices are analyzed. Implications for children and families historically marginalized and disempowered are discussed along with recommendations for more socially just policies and practices

Mechanical performance of statically loaded flat face epoxy bonded concrete joints

One of the main challenges in the offshore renewable energy industry is the reduction in the levelised cost of energy of wind, wave and tidal devices. The use of concrete as the primary construction material in such devices presents a low unit cost, high marine durability alternative to steel, however, to maximise material efficiency factors such as mix constituent design, structural detailing and manufacturing processes have to take into account the specific conditions of the marine environment. Pre-cast segmental construction can be considered as one of the fastest and cheapest construction options. However the challenges regarding performance of epoxy bonded concrete in marine environment should be taken into account. This paper presents the results of an experimental programme on the performance of shear and tensile capacity of flat face concrete joints, focussing on the effect of substrate surface preparation, joint thickness, properties of epoxy resins, exposure to seawater and presence of joint defects on the ultimate failure load. The ultrasonic pulse velocity (UPV) method for detection of defects in the adhesive layer was examined and digital image correlation is used to observe the surface strain flow through the joint. The results indicate that the epoxy joints behave monolithically and remain undamaged under different types of static loading. The joints do not significantly interrupt the flow of strain but can locally affect the distribution of strain (and thus stiffness and stresses) in a structure. An increase in the density of the epoxy (and the filler content) leads to the increase in the joint strength and thicker joints are less affected by small defects in the bonding layer. The majority of tested specimens failed by cracking of concrete rather than by debonding of the joint, whilst compressive stresses acting on the joint can help to augment its shear strength. Sandblasting of bonded surfaces can improve performance of joints, whereas UPV testing may be used for quality control of epoxy-bonded joints