Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis

BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesions and relapses during the first year of treatment predict a poor prognosis. OBJECTIVE: To study this association in those receiving natalizumab. METHODS: Data were collected on relapses, new MRI activity, and Modified Rio Score after initiation of natalizumab in an observational cohort of 161 patients with high baseline disability. These were correlated with Expanded Disability Status Scale (EDSS) progression at years 1, 2, 3, and 3-7 after treatment initiation, versus pre-treatment baseline. RESULTS: 46/161 patients had a relapse in the first year and 44/161 had EDSS progression by year 2. Relapses and Modified Rio Score in the first year of treatment predicted EDSS progression at year 1 and 2 after treatment initiation. However, this effect disappeared with longer follow-up. Paradoxically, there was a trend towards inflammatory activity on treatment (first year Modified Rio Score, relapses, and MRI activity) predicting a lower risk of EDSS progression by years 3-7, although this did not reach statistical significance. Those with and without EDSS progression did not differ in baseline age, EDSS, or pre-treatment relapse rate. Relapses in year 0-1 predicted further relapses in years 1-3. CONCLUSIONS: Breakthrough inflammatory activity after natalizumab treatment is predictive of short-term outcome measures of relapses or EDSS progression, but does not predict longer term EDSS progression, in this cohort with high baseline disability

Mode-switching: a new technique for electronically varying the agglomeration position in an acoustic particle manipulator

Acoustic radiation forces offer a means of manipulating particles within a fluid. Much interest in recent years has focussed on the use of radiation forces in microfluidic (or “lab on a chip”) devices. Such devices are well matched to the use of ultrasonic standing waves in which the resonant dimensions of the chamber are smaller than the ultrasonic wavelength in use. However, such devices have typically been limited to moving particles to one or two predetermined planes, whose positions are determined by acoustic pressure nodes/anti-nodes set up in the ultrasonic standing wave. In most cases devices have been designed to move particles to either the centre or (more recently) the side of a flow channel using ultrasonic frequencies that produce a half or quarter wavelength over the channel, respectively.It is demonstrated here that by rapidly switching back and forth between half and quarter wavelength frequencies – mode-switching – a new agglomeration position is established that permits beads to be brought to any arbitrary point between the half and quarter-wave nodes. This new agglomeration position is effectively a position of stable equilibrium. This has many potential applications, particularly in cell sorting and manipulation. It should also enable precise control of agglomeration position to be maintained regardless of manufacturing tolerances, temperature variations, fluid medium characteristics and particle concentration

Error-proof programmable self-assembly of DNA-nanoparticle clusters

We study theoretically a new generic scheme of programmable self-assembly of nanoparticles into clusters of desired geometry. The problem is motivated by the feasibility of highly selective DNA-mediated interactions between colloidal particles. By analyzing both a simple generic model and a more realistic description of a DNA-colloidal system, we demonstrate that it is possible to suppress the glassy behavior of the system, and to make the self-assembly nearly error-proof. This regime requires a combination of stretchable interparticle linkers (e.g. sufficiently long DNA), and a soft repulsive potential. The jamming phase diagram and the error probability are computed for several types of clusters. The prospects for the experimental implementation of our scheme are also discussed. PACS numbers: 81.16.Dn, 87.14.Gg, 36.40.EiComment: 6 pages, 4 figures, v2: substantially revised version, added journal re

Clinical encounters about obesity: Systematic review of patients' perspectives.

Guidelines recommend clinicians intervene on obesity but it is unclear how people with overweight react. In this systematic review, we searched 20 online databases for qualitative studies interviewing people with overweight or obesity who had consulted a primary care clinician. Framework synthesis was used to analyse 21 studies to produce a new theoretical understanding. Consultations in which patients discussed their weight were more infrequent than patients would have liked, which some perceived was because they were unworthy of medical time; others that it indicated doctors feel being overweight is not a serious risk. Patients reported that doctors offered banal advice assuming that the patient ate unhealthily or was not trying to address their weight. Patients reported doctors assumed that their symptoms were due to overweight without a proper history or examination, creating concern that serious illness may be missed. Patients responded positively to offers of support for weight loss and active monitoring of weight. Patients with overweight internalize weight stigma sensitizing them to clues that clinicians are judging them negatively, even if weight is not discussed. Patients' negative experiences in consultations relate to perceived snap judgements and flippant advice and negative experiences appear more salient than positive ones

Double impact: what sibling data can tell us about the long-term negative effects of parental divorce

Journal ArticleMost prior research on the adverse consequences of parental divorce has analyzed only one child per family. As a result, it is not known whether the same divorce affects siblings differently. We address this issue by analyzing paired sibling data from the 1994 General Social Survey (GSS) and 1994 Survey of American Families (SAF). Both seemingly unrelated regressions and random effects models are used to study the effect of family background on offspring's educational attainment and marital stability. Parental divorce adversely affects the educational attainment and the probability of divorce of both children within a sibship; in other words, siblings tend to experience the same divorce the same way. However, family structure of origin only accounts for a trivial portion of the shared variance in offspring's educational attainment and marital stability, so parental divorce is only one of many factors determining how offspring fare. These findings were unchanged when controlling for a number of differences both between and within sibships. Also, the negative effects of parental divorce largely do not vary according to respondent characteristics

Spectral Absorption Coefficient of Additive Manufacturing Polymers

As NASA turns to additive manufacturing processes, there is a need to ensure that the parts they produce are reliable. This is especially true when creating parts in space, where resources are limited and failure could result in catastrophe. Active thermography has shown potential as a non-destructive quality assurance technique for additive manufacturing processes. Heat transfer models used in active thermography techniques require accurate material property measurements in order to extract useful information about the system, including defect location. The spectral absorption coefficient, which determines the depth at which radiative power is absorbed into a surface, is a material property necessary for performing active thermography on AM polymers. This paper presents measurements of spectral absorption coefficients of polymers commonly used in additive manufacturing. Spectral absorption coefficients for fully dense PLA, ABS, and Nylon 12 samples are reported. Future work is needed to measure the spectral absorption coefficients of different materials and colored filaments commonly used in additive manufacturing

Novel approaches to Newtonian noise suppression in interferometric gravitational wave detection

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 63-65).The Laser Interferometer Gravitational-wave Observatory (LIGO) attempts to detect ripples in the curvature of spacetime using two large scale interferometers. These detectors are several kilometer long Michelson interferometers with Fabry-Perot cavities between two silica test masses in each arm. Given Earth's proximity to various astrophysical phenomena LIGO must be sensitive to relative displacements of 1018 m and thus requires multiple levels of noise reduction to ensure the isolation of the interferometer components from numerous sources of noise. A substantial contributor to the Advanced LIGO noise in the 1-10 Hz range is Newtonian (or gravity gradient) noise which arises from local fluctuations in the Earth's gravitational field. Density fluctuations from seismic activity as well as acoustic and turbulent phenomenon in the Earth's atmosphere both contribute to slight variations in the local value of g. Given the direct coupling of gravitational fields to mass the LIGO test masses cannot be shielded from this noise. In an attempt to characterize and reduce Newtonian noise in interferometric gravitational wave detectors we investigate seismic and atmospheric contributions to the noise and consider the effect of submerging a gravitational wave detector.by Nicholas R. Hunter-Jones.S.B

Chaos and Randomness in Strongly-Interacting Quantum Systems

Quantum chaos entails an entropic and computational obstruction to describing a system and thus is intrinsically difficult to characterize. An understanding of quantum chaos is fundamentally related to the mechanism of thermalization in many-body systems and the quantum nature of black holes. In this thesis we adopt the view that quantum information theory provides a powerful framework in which to elucidate chaos in strongly-interacting quantum systems. We first push towards a more precise understanding of chaotic dynamics by relating different diagnostics of chaos, studying the time-evolution of random matrix Hamiltonians, and quantifying random matrix behavior in physical systems. We derive relations between out-of-time ordered correlation functions, spectral quantities, and frame potentials to relate the scrambling of quantum information, decay of correlators, and Haar-randomness. We give analytic expressions for these quantities in random matrix theory to explore universal aspects of late-time dynamics. Motivated by our random matrix results, we define k-invariance in order to capture the onset of random matrix behavior in physical systems. We then refine our diagnostics in order to study chaotic systems with symmetry by considering Haar-randomness with respect to quotients of the unitary group, and in doing so we generalize our quantum information machinery. We further consider extended random matrix ensembles in the context of strongly-interacting quantum systems dual to black holes. Lastly, we study operator growth in classes of random quantum circuits.</p