128 research outputs found

    The Experience of Homeless Ex-service Personnel in London

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    CD28- cells are increased in early rheumatoid arthritis and are linked with cytomegalovirus status

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    Objective: CD3+CD8+CD28− cells are higher in Rheumatoid Arthritis (RA). The aim of this study was to assess CD3+CD8+CD28− cells in patients with early RA and assess the effects of cytomegalovirus (CMV) seropositivity. Method: In this prospective observation study, 50 RA patients were recruited from Cardiff University Hospital of Wales (UHW) rheumatology outpatient, 25 patients with early disease (disease duration 0–6 months) and 25 patients with established disease (>2 years). These were compared with 25 healthy controls. Clinical and serological markers of inflammation were noted, and peripheral blood mononuclear cells were analyzed using flow cytometry. Results: The percentage of the CD8+CD28− T cells was increased in RA patients and was associated with disease duration. The percentage of CD8+CD28− T cells was increased in CMV positive early and established RA grouped and early RA patients in comparison to CMV negative patients (p < 0.05). There is a weak but statistically significant correlation between the percentage of CD3+CD8+CD28− cells and CRP in CMV positive RA patients (r = 0.227, p < 0.05). Conclusion: The percentage of CD8+CD28− T cells is higher in RA patients and correlates with disease duration, highlighting a potential role early in the disease process. These cells were also higher in CMV positive early RA patients which may suggest a role of CMV in disease development

    Access to General Practice for People Sleeping Rough

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    The objectives of the research were simple. First, it was to produce maps of England showing those areas in which people sleeping rough were having persistent problems in gaining access to GP services. Second, it was to investigate why these problems in access were arising. Third, although the concentration of the research was to be on access to GPs, some assessment of the quality of care being received by people sleeping rough was to be undertaken. People sleeping rough generally need access to health services if their resettlement into housing is to be successful. The high prevalence of severe mental illness and drug or alcohol addiction among people sleeping rough often means that they will be unable to sustain themselves in a tenancy without medical and practical support. Access to GP services can therefore be a prerequisite for effective resettlement

    Ten-Year Secular Changes in Selected Health and Fitness Parameters of 10-11 Years Old Swansea School Children – 2003-2013

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    Purpose: The aim of this study was to highlight the secular changes in selected health and fitness measures (body mass index, prevalence of overweight and obesity and grip strength) in 10-11 year old Swansea school children, using data obtained in 2003 and 2013.Methods: Stature, body mass and grip strength data were collected for 512 participants (n= 230 boys, n= 282 girls) in 2003 during a Crucial CrewDay and for 414 participants (n= 198 boys, n= 216 girls) in 2013 during the Swan-Linx programme. BMIs were calculated from this data and used to calculate BMI standard deviation scores. A two-way ANOVA was conducted to examine if there was a statistically significant difference in BMI z-score by gender and year of testing. A two-way ANCOVA was used to investigate if there were differences on grip strength by gender and year of testing, with BMI z-score as a covariate.Results: BMI z-scores decreased significantly (p = 0.001) between 2003 and 2013 for both boys (0.80 to 0.40) and girls (0.58 to 0.41). Prevalence of overweight and obesity decreased for both boys and girls from 31.7% to 23.8% and 33.8% to 29.7%, respectively. After BMI z-scores adjustment, grip strength decreased significantly for boys (18.43kg to 16.88kg, p < 0.001), but not for girls (16.53kg to 16.59kg).Conclusion: The study shows promising results in terms of BMI z-scores and prevalence of overweight and obesity. However, the prevalence of overweight and obesity recorded in 2013 is still high, therefore further decreases in prevalence should continue to be an aim. The study also shows that muscular strength, in boys in particular, should be a focus for future interventions regarding physical fitness, in addition to an area for further investigation
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