An Investigation into the Sonic Signature of Three Classic Dynamic Range Compressors

Dynamic range compression (DRC) is a much-used process in music production. Traditionally the process was implemented in order to control the dynamic range of program material to minimize the potential of overloading recording devices. However, over time DRC became a process that was applied more as a creative effect and less as a preventative measure. In a professional recording environment it is not uncommon for engineers to have access to several different types of DRC unit, each with their own purportedly unique sonic signature. This paper investigates the differences between three popular vintage dynamic range compressors by conducting a number of measurements on the devices. The compressors were tested using: THD measurements, tone bursts, and objective analysis of music-based material using spectrum analysis and audio feature extracti

Protecting mammalian hair cells from aminoglycoside-toxicity: assessing phenoxybenzamine’s potential

Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic,causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering agents that protect against aminoglycoside ototoxicity have focused on inhibiting apoptosis or more recently, on preventing antibiotic uptake by the hair cells. Recent screens for ototoprotective compounds using the larval zebrafish lateral line identified phenoxybenzamine as a potential protectant for aminoglycoside induced hair cell death. Here we used live imaging of FM1-43 uptake as a proxy for aminoglycoside entry, combined with hair-cell death assays to evaluate whether phenoxybenzamine can protect mammalian cochlear hair cells from the deleterious effects of the aminoglycoside antibiotic neomycin. We show that phenoxybenzamine can block FM1-43 entry into mammalian hair cells in a reversible and dose-dependent manner, but pre-incubation is required for maximal inhibition of entry. We observed differential effects of phenoxybenzamine on FM1-43 uptake in the two different types of cochlear hair cell in mammals, the outer hair cells (OHCs) and inner hair cells (IHCs).The requirement for pre-incubation and reversibility suggests an intracellular rather than an extracellular site of action for phenoxybenzamine. We also tested the efficacy of phenoxybenzamine as an otoprotective agent. In mouse cochlear explants the hair cell death resulting from 24 h exposure to neomycin was steeply dose-dependent, with 50% cell death occurring at ~230 uM for both IHC and OHC. We used 250 uM neomycin in subsequent hair-cell death assays. At 100 uM with 1 h pre-incubation, phenoxybenzamine conferred significant protection to both IHCs and OHCs, however at higher concentrations phenoxybenzamine itself showed clear signs of ototoxicity and an additive toxic effect when combined with neomycin. These data do not support the use of phenoxybenzamine as a therapeutic agent in mammalian inner ear. Our findings do share parallels with the observations from the zebrafish lateral line model but they also highlight the necessity for validation in the mammalian system and the potential for differential effects on sensory hair cells from different species, in different systems and even between cells in the same organ

Astrometric Effects of Gravitational Wave Backgrounds with non-Luminal Propagation Speeds

A passing gravitational wave causes a deflection in the apparent astrometric positions of distant stars. The effect of the speed of the gravitational wave on this astrometric shift is discussed. A stochastic background of gravitational waves would result in a pattern of astrometric deflections which are correlated on large angular scales. These correlations are quantified and investigated for backgrounds of gravitational waves with sub- and super-luminal group velocities. The statistical properties of the correlations are depicted in two equivalent and related ways: as correlation curves and as angular power spectra. Sub-(super-)luminal gravitational wave backgrounds have the effect of enhancing (suppressing) the power in low-order angular modes. Analytical representations of the redshift-redshift and redshift-astrometry correlations are also derived. The potential for using this effect for constraining the speed of gravity is discussed.ER

Brief communication: landslide motion from cross correlation of UAV-derived morphological attributes

Unmanned aerial vehicles (UAVs) can provide observations of high spatio-temporal resolution to enable operational landslide monitoring. In this research, the construction of digital elevation models (DEMs) and orthomosaics from UAV imagery is achieved using structure-from-motion (SfM) photogrammetric procedures. The study examines the additional value that the morphological attribute of "openness", amongst others, can provide to surface deformation analysis. Image-cross-correlation functions and DEM subtraction techniques are applied to the SfM outputs. Through the proposed integrated analysis, the automated quantification of a landslide's motion over time is demonstrated, with implications for the wider interpretation of landslide kinematics via UAV surveys

Efficacy of face coverings in reducing transmission of COVID-19:Calculations based on models of droplet capture

In the COVID--19 pandemic, among the more controversial issues is the use of masks and face coverings. Much of the concern boils down to the question -- just how effective are face coverings? One means to address this question is to review our understanding of the physical mechanisms by which masks and coverings operate -- steric interception, inertial impaction, diffusion and electrostatic capture. We enquire as to what extent these can be used to predict the efficacy of coverings. We combine the predictions of the models of these mechanisms which exist in the filtration literature and compare the predictions with recent experiments and lattice Boltzmann simulations, and find reasonable agreement with the former and good agreement with the latter. Building on these results, we explore the parameter space for woven cotton fabrics to show that three-layered cloth masks can be constructed with comparable filtration performance to surgical masks under ideal conditions. Reusable cloth masks thus present an environmentally friendly alternative to surgical masks so long as the face seal is adequate enough to minimise leakage.Comment: 26 pages (13 + references, 10 pages supplementary), 10 figures (8 in main text, 2 in SI); accepted version, to appear in Physics of Fluids' special issue "Flow and the Virus

The reduction of intoxication and disorder in premises licensed to serve alcohol: An exploratory randomised controlled trial

Background: Licensed premises offer a valuable point of intervention to reduce alcohol-related harm. Objective: To describe the research design for an exploratory trial examining the feasibility and acceptability of a premises-level intervention designed to reduce severe intoxication and related disorder. The study also aims to assess the feasibility of a potential future large scale effectiveness trial and provide information on key trial design parameters including inclusion criteria, premises recruitment methods, strategies to implement the intervention and trial design, outcome measures, data collection methods and intra-cluster correlations. Design: A randomised controlled trial in licensed premises that had experienced at least one assault in the year preceding the intervention, documented in police or hospital Emergency Department (ED) records. Premises were recruited from four study areas by piloting four recruitment strategies of varying intensity. Thirty two licensed premises were grouped into matched pairs to reduce potential bias and randomly allocated to the control or intervention condition. The study included a nested process evaluation to provide information on intervention acceptability and implementation. Outcome measures included police-recorded violent incidents, assault-related attendances at each premises ’ local ED and patron Breath Alcohol Concentration assessed on exiting and entering study premises. Results: The most successful recruitment method involved local police licensing officers and yielded a 100% success rate. Police-records of violence provided the most appropriate source of data about disorder at the premises level. Conclusion: The methodology of an exploratory trial is presented and despite challenges presented by the study environment it is argued an exploratory trial is warranted. Initial investigations in recruitment methods suggest that study premises should be recruited with the assistance of police officers. Police data were of sufficient quality to identify disorder and street surveys are a feasible method for measuring intoxication at the individual level. Trial registration: UKCRN 7090; ISRCTN: 80875696. Funding: Medical Research Council (G0701758) to Simon Moore, Simon Murphy, Laurence Moore and Jonathan Shepherd.

Exercise training and weight loss, not always a happy marriage: single blind exercise trials in females with diverse BMI

Individuals show high variability in body weight responses to exercise training. Expectations and motivation towards effects of exercise on body weight might influence eating behaviour and could conceal regulatory mechanisms. We conducted two single-blind exercise trials (4 weeks (study 1) and 8 weeks (study 2)) with concealed objectives and exclusion of individuals with weight loss intention. Circuit exercise training programs (3 times a week (45-90 min), intensity 50-90% VO2peak, for 4 and 8 weeks) were conducted. 34 females finished the 4 weeks intervention and 36 females the 8 weeks intervention. Overweight/obese (OV/OB) and lean (L) female participants´ weight/body composition responses were assessed and fasting and postprandial appetite hormone levels (PYY, insulin, amylin, leptin, ghrelin) were measured pre and post intervention for understanding potential contribution to individuals’ body weight response to exercise training (study 2). Exercise training in both studies did not lead to a significant reduction of weight/BMI in the participants’ groups, however, lean participants gained muscle mass. Appetite hormones levels were significantly (p<0.05) altered in the OV/OB group affecting fasting (-24%) and postprandial amylin (-14%) levels. Investigation of individuals’ BMI responses using multiple regression analysis revealed that levels of fasting leptin, postprandial amylin increase, and BMI were significant predictors of BMI change explaining about 43% of the variance. In conclusion, tested exercise training did not lead to weight loss in female participants, while a considerable proportion of variance in body weight response to training could be explained by individuals’ appetite hormone levels and BMI