Interactive, Holistic, and Experiential Criminal Justice Online Learning Environment

The study is designed to test the effectiveness of specific experiential e-learning strategies for criminal justice students, this study seeks to determine how a comprehensive series of videos that includes a criminal trial and interviews of the judge, defense counsel, prosecution, investigators and court director discussing their roles enhanced course and learning outcomes. The second study purpose is to test the effectiveness of a comprehensive and interactive criminal justice computer model that allows the students to work within the multifaceted and complex system and explore descriptions, concepts, theories, relationships, and sequences in order to enhance learning outcomes regarding the system(s) of justice, its challenges, and opportunities. The study will be a mixed methods study concentrating on both focus groups and a survey instrument for evaluation of effectiveness variables. The analysis will help to discern the quality and effectiveness of the digital learning tools both from the student perspective and the field expert perspective.https://fuse.franklin.edu/ss2014/1025/thumbnail.jp

Institute of Criminal Justice Excellence: Providing Information through Innovation and Dialogue

The Ohio Department of Rehabilitation and Corrections, Deputy Director for Re-Entry Programs and Dr. Karen Miner-Romanoff at Franklin University have partnered to create a one of a kind Institute of dialogue, information sharing, and non-partisan evidenced-based practice communication. The Franklin University Coalition for Criminal Justice Excellence (CJE) is a partnership with the Ohio Department of Rehabilitation and Corrections and is a nonpartisan effort to join lawyers, legal scholars, social science experts, government officials, nonprofit leaders, judges, administrators, corrections and law enforcement professionals, stakeholders and practitioners in the form of roundtables, forums, events and speaker series to address the pragmatic issues faced by professionals and communities today. It seeks to educate the general public on criminal justice issues toward data-driven laws and policies that increase public safety and promote cooperation among diverse stakeholders through community discussions and education. Its mission is to provide a holistic, nonpartisan forum for diverse stakeholders and criminal justice practitioners that encourage the exchange of ideas, experiences, and data sharing while providing a professional forum for cross-agency information flow and discourse. It seeks to improve the quality and delivery of criminal justice services, advance knowledge of administrative best practices and the educational and civic mission of Franklin University and its criminal justice programs through consensus-driven best practices.https://fuse.franklin.edu/ss2014/1030/thumbnail.jp

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in th

Using LibGuides to Promote Faculty/Librarian Interaction

See presentation description

Protective and pathogenic effects of interferon signaling during pregnancy

Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus

A human STAT1 gain-of-function mutation impairs CD8 + T cell responses against gammaherpesvirus 68

Autosomal dominant STAT1 mutations in humans have been associated with chronic mucocutaneous candidiasis (CMC), as well as with increased susceptibility to herpesvirus infections. Prior studies have focused on mucosal and Th17-mediated immunity agains

The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice

STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop αβ T cell-dependent lung disease and also lack lymph nodes. Although SAVI has been regarded as a type I interferonopathy, the relative contributions of the three interferon receptors are incompletely understood. Here, we show that STING gain of function led to upregulation of IFN-γ-induced chemokines in the lungs of SAVI mice and that deletion of the type II IFN receptor (IFNGR1), but not the type I IFN receptor (IFNAR1) or type III IFN receptor (IFNλR1), ameliorated lung disease and restored lymph node development in SAVI mice. Furthermore, deletion of IFNGR1, but not IFNAR1 or IFNλR1, corrected the ratio of effector to Tregs in SAVI mice and in mixed bone marrow chimeric mice. Finally, cultured SAVI mouse macrophages were hyperresponsive to IFN-γ, but not IFN-β, in terms of Cxcl9 upregulation and cell activation. These results demonstrate that IFNGR1 plays a major role in autoinflammation and immune dysregulation mediated by STING gain of function