15 research outputs found
What's the Problem? Cultural Capability and Learning from Historical Performance
Contains the cis-eQTLs with P valueâÂÂ<âÂÂ5Ă % for T-cells obtained from early undifferentiated arthritis patients. (TXT 1162 kb
Haplotype and homozygous frequency of DLA-DRB1*02001/DQA1*00401/DQB1*01303 in cases and âgraded controlsâ.
<p>Haplotype and homozygous frequency of DLA-DRB1*02001/DQA1*00401/DQB1*01303 in cases and âgraded controlsâ.</p
Association of the DLA-DRB1*02001/DQA1*00401/DQB1*01303 genotypes with polymyositis, relative to the disease risk in individuals who are DLA-DRB1*02001/DQA1*00401/DQB1*01303 homozygous negative.
<p>Association of the DLA-DRB1*02001/DQA1*00401/DQB1*01303 genotypes with polymyositis, relative to the disease risk in individuals who are DLA-DRB1*02001/DQA1*00401/DQB1*01303 homozygous negative.</p
The criteria used to assign cases to a diagnostic confidence grouping.
<p>The criteria used to assign cases to a diagnostic confidence grouping.</p
Frequencies of the DLA haplotypes found in Hungarian Vizslas.
<p>Frequencies of the DLA haplotypes found in Hungarian Vizslas.</p
Type II diabetes mellitus and cardiovascular markers in humans: a prospective study in hellenic homogeneous population
Approximately 200 million people, worldwide, are currently having Type 2 diabetes mellitus (T2DM), a prevalence that has been predicted to increase to 366 million by 2030. Atherosclerotic coronary heart disease (CHD) and other forms of
cardiovascular disease (CYD) are the major cause of mortality in T2DM as well as a major contributor to morbidity and lifetime costs.
A number of unfavorable conditions predisposing to CVD coexist with diabetic status including hyperglycaemia, dyslipidaemia, inflammation and coagulation, many of which may be closely associated with insulin resistance. In addition, mutations and polymorphisms in a number of genes have also been linked with monogenic and polygenic forms of T2DM. In this respect, the possible relationship between these disorders and a number of biochemical factors in a selection of different age groups of diabetic patients was studied.
The purpose of the present work was the identification of biochemical parameters in plasma, which may serve as predisposition factors to CVD in T2DM patients of different age. The variability of hyperglycaemia, dyslipidaemia, and inflammation with age progression were studied.
Four different diabetic groups allocated based on the subjects age (Group A:15-25 years old; Group 13:26-40 years old; Group C:40-60 years old; Group D:60-80 years old) and consisting of ten patients each, in parallel with ten matched for age, sex and ethnic origin healthy controls, were screened for glucose, insulin, lipid profile (total cholesterol, triglycerides, LDL and HDL) and inflammatory mediators (Homocysteine, CRP, IL-6, TNF-a).
Significant differences were observed between the expression of biochemical markers among different age groups. Hyperglycaemia showed no variability with age whereas dyslipidaemia correlated positively with age progression, as well as obesity, low physical activity and family history of heart disease or diabetes. Marked inflammation was prominent only in Groups C and D.
The present study indicates that different biochemical parameters may be used for assessment of CVD risk in T2DM patients of variable age
Overview of MS 6q23 interactions.
<p>Tracks are labelled as follows: AâLD regions targeted in âregionâ Capture Hi-C; BâGene regions targeted in âpromoterâ Capture Hi-C; CâRefSeq genes (packed for clarity); DâMS index SNPs; EâMS LD regions; FâInteractions observed in the GM12878 B-cell line and GâInteractions observed in the Jurkat T-cell line. Promoter and region Capture Hi-C experiments have been merged for clarity. The genomic region chr6:136,650,000â137,280,000 has been omitted for clarity. All co-ordinates are based on GRCh37. Generated using the WashU EpiGenome Browser (<a href="http://epigenomegateway.wustl.edu/browser/" target="_blank">http://epigenomegateway.wustl.edu/browser/</a>).</p
Associated SNP genotypes for GM12878 (B) and Jurkat (T) cell lines.
<p>Associated SNP genotypes for GM12878 (B) and Jurkat (T) cell lines.</p
Increased expression of <i>IL20RA</i> in primary CD8+ T-cells from 21 healthy individuals carrying the G risk allele of rs17066096, <i>P</i> = 0.01.
<p>The three different genotypes for the SNPs are displayed on the X axis and gene expression levels on the Y axis. Error bars indicate standard deviation.</p
Refined MS SNPs based on bioinformatics and Capture Hi-C data.
<p>Refined MS SNPs based on bioinformatics and Capture Hi-C data.</p