10-05 "The Macroeconomics of Development without Throughput Growth"

Serious discussion has begun of policies to promote the goal of increasing well-being without material growth. Moving towards this goal requires a profound reorientation of macroeconomic theory. Importantly, the call by ecological economists to move away from traditional growth-oriented models comes at a moment when standard macroeconomics is in considerable turmoil. The financial crisis of 2008/2009 seriously undermined the basis for mainstream macroeconomics and brought renewed attention to various forms of Keynesian analysis and policy previously regarded as outdated. There is a close complementarity between new Keynesian and ecological perspectives. While older Keynesian analysis was oriented towards promoting growth, a true Keynesian analysis of the relationship between investment and consumption does not depend on a growth orientation. What this analysis has in common with an ecological perspective is the rejection of market optimality assumed in classical models. Moving away from the neoclassical goal of inter-temporal utility maximization allows for different, pluralistic economic goals: full employment, provision of basic needs, social and infrastructure investment, and income equity. These goals are compatible with environmental preservation and resource sustainability, whereas indefinite growth is not. But they require a revitalization of the sphere of social investment, seriously neglected (indeed often omitted completely) in standard models. Reintroducing this perspective allows the development of an economic theory suitable for the transition to a stable-population, low-carbon, resource-conserving global economy. The barriers to this transition are primarily political and institutional, not economic. Specifically, an eco-Keynesian perspective emphasizes new macroeconomic categories including: * human-capital-intensive services * investment in energy-conserving capital * investment in natural and human capital The expansion of these categories provides a basis for growth in wellbeing without growth in throughput, while preserving full employment and economic stability. This paper explores some of the implications of this altered macroeconomic perspective for development in both the global "North" and "South". It is suggested that the problems following the global financial crisis cannot be resolved by a return to traditional growth patterns, and will require large-scale practical policies based on eco-Keynesianism.

A Bootstrapping Approach for Generating Maximally Path-Entangled Photon States

We propose a bootstrapping approach to generation of maximally path-entangled states of photons, so called ``NOON states''. Strong atom-light interaction of cavity QED can be employed to generate NOON states with about 100 photons; which can then be used to boost the existing experimental Kerr nonlinearities based on quantum coherence effects to facilitate NOON generation with arbitrarily large number of photons all within the current experimental state of the art technology. We also offer an alternative scheme that uses an atom-cavity dispersive interaction to obtain sufficiently high Kerr-nonlinearity necessary for arbitrary NOON generation

Extending CMIP5 projections of global mean temperature change and sea level rise due to the thermal expansion using a physically-based emulator

We present a physically-based emulator approach to extending 21st century CMIP5 model simulations of global mean surface temperature (GMST) and global thermal expansion (TE) to 2300. A two-layer energy balance model that has been tuned to emulate the CO2 response of individual CMIP5 models is combined with model-specific radiative forcings to generate an emulated ensemble to 2300 for RCP2.6, RCP4.5 and RCP8.5. Errors in the emulated time series are quantified using a subset of CMIP5 models with data available to 2300 and factored into the ensemble uncertainty. The resulting projections show good agreement with 21st century ensemble projections reported in IPCC AR5 and also compare favourably with individual CMIP5 model simulations post-2100. There is a tendency for the two-layer model simulations to overestimate both GMST rise and TE under RCP2.6, which is suggestive of a systematic error in the applied radiative forcings. Overall, the framework shows promise as a basis for extending process-based projections of global sea level rise beyond the 21st century time horizon that typifies CMIP5 simulations. The results also serve to illustrate the differing responses of GMST and Earth's energy imbalance (EEI) to reductions in greenhouse gas emissions. GMST responds relatively quickly to changes in emissions, leading to a negative trend post-2100 for RCP2.6, although temperature remains substantially elevated compared to present day at 2300. In contrast, EEI remains positive under all RCPs, and results in ongoing sea level rise from TE

Spatio-temporal spread of COVID-19 and its associations with socioeconomic, demographic and environmental factors in England:A Bayesian hierarchical spatio-temporal model

<p>Exploring the spatio-temporal variations of COVID-19 transmission and its potential determinants could provide a deeper understanding of the dynamics of disease spread. This study aims to investigate the spatio-temporal spread of COVID-19 infection rate in England, and examine its associations with socioeconomic, demographic and environmental risk factors. Using weekly reported COVID-19 cases from 7 March 2020 to 26 March 2022 at Middle Layer Super Output Area (MSOA) level in mainland England, we developed a Bayesian hierarchical spatio-temporal model to predict the COVID-19 infection rates and investigate the influencing factors. The analysis showed that our model outperformed the ordinary least squares (OLS) and geographically weighted regression (GWR) models in terms of prediction accuracy. The results showed that the spread of COVID-19 infection rates over space and time was heterogeneous. Hotspots of infection rate exhibited inconsistent clustered patterns over time. Among the selected risk factors, the annual household income, unemployment rate, population density, percentage of Caribbean population, percentage of adults aged 45-64 years old, and particulate matter concentrations were found to be positively associated with the COVID-19 infection rate. The findings assist policymakers in developing tailored public health interventions for COVID-19 prevention and control.</p&gt

Generic local distinguishability and completely entangled subspaces

A subspace of a multipartite Hilbert space is completely entangled if it contains no product states. Such subspaces can be large with a known maximum size, S, approaching the full dimension of the system, D. We show that almost all subspaces with dimension less than or equal to S are completely entangled, and then use this fact to prove that n random pure quantum states are unambiguously locally distinguishable if and only if n does not exceed D-S. This condition holds for almost all sets of states of all multipartite systems, and reveals something surprising. The criterion is identical for separable and for nonseparable states: entanglement makes no difference.Comment: 12 page

Genomic organization and evolution of the ULBP genes in cattle

BACKGROUND: The cattle UL16-binding protein 1 (ULBP1) and ULBP2 genes encode members of the MHC Class I superfamily that have homology to the human ULBP genes. Human ULBP1 and ULBP2 interact with the NKG2D receptor to activate effector cells in the immune system. The human cytomegalovirus UL16 protein is known to disrupt the ULBP-NKG2D interaction, thereby subverting natural killer cell-mediated responses. Previous Southern blotting experiments identified evidence of increased ULBP copy number within the genomes of ruminant artiodactyls. On the basis of these observations we hypothesized that the cattle ULBPs evolved by duplication and sequence divergence to produce a sufficient number and diversity of ULBP molecules to deliver an immune activation signal in the presence of immunogenic peptides. Given the importance of the ULBPs in antiviral immunity in other species, our goal was to determine the copy number and genomic organization of the ULBP genes in the cattle genome. RESULTS: Sequencing of cattle bacterial artificial chromosome genomic inserts resulted in the identification of 30 cattle ULBP loci existing in two gene clusters. Evidence of extensive segmental duplication and approximately 14 Kbp of novel repetitive sequences were identified within the major cluster. Ten ULBPs are predicted to be expressed at the cell surface. Substitution analysis revealed 11 outwardly directed residues in the predicted extracellular domains that show evidence of positive Darwinian selection. These positively selected residues have only one residue that overlaps with those proposed to interact with NKG2D, thus suggesting the interaction with molecules other than NKG2D. CONCLUSION: The ULBP loci in the cattle genome apparently arose by gene duplication and subsequent sequence divergence. Substitution analysis of the ULBP proteins provided convincing evidence for positive selection on extracellular residues that may interact with peptide ligands. These results support our hypothesis that the cattle ULBPs evolved under adaptive diversifying selection to avoid interaction with a UL16-like molecule whilst preserving the NKG2D binding site. The large number of ULBPs in cattle, their extensive diversification, and the high prevalence of bovine herpesvirus infections make this gene family a compelling target for studies of antiviral immunity

The effect of gaze angle on visual acuity in infantile nystagmus

Purpose: Most individuals with infantile nystagmus (IN) have an idiosyncratic gaze angle at which their nystagmus intensity is minimized. Some adopt an abnormal head posture to use this “null zone,” and it has therefore long been assumed that this provides people with nystagmus with improved visual acuity (VA). However, recent studies suggest that improving the nystagmus waveform could have little, if any, influence on VA; that is, VA is fundamentally limited in IN. Here, we examined the impact of the null zone on VA. Methods: Visual acuity was measured in eight adults with IN using a psychophysical staircase procedure with reversals at three horizontal gaze angles, including the null zone. Results: As expected, changes in gaze angle affected nystagmus amplitude, frequency, foveation duration, and variability of intercycle foveation position. Across participants, each parameter (except frequency) was significantly correlated with VA. Within any given individual, there was a small but significant improvement in VA (0.08 logMAR) at the null zone as compared with the other gaze angles tested. Despite this, no change in any of the nystagmus waveform parameters was significantly associated with changes in VA within individuals. Conclusions: A strong relationship between VA and nystagmus characteristics exists between individuals with IN. Although significant, the improvement in VA observed within individuals at the null zone is much smaller than might be expected from the occasionally large variations in intensity and foveation dynamics (and anecdotal patient reports of improved vision), suggesting that improvement of other aspects of visual performance may also encourage use of the null zone