Additional file 1: of An attenuated rate of leg muscle protein depletion and leg free amino acid efflux over time is seen in ICU long-stayers

Table S1. Individual patients characteristics. Table S2. Patient characteristics at the two measurement points. Figure S1. Longitudinal presentation of plasma flow. Figure S2. Longitudinal presentation of phenylalanine turnover using the two-pool model. Figure S3. Longitudinal presentation of SOFA scores and nutrition. Figure S4. Longitudinal presentation of all amino acid fluxes. Figure S5. Amino acid concentrations. (PDF 185 kb

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p