Transcriptional control of behaviour: engrailed knockout changes cockroach escape trajectories

The cerci of the cockroach are covered with identified sensory hairs that detect air movements. The sensory neurons that innervate these hairs synapse with giant interneurons in the terminal ganglion that in turn synapse with interneurons and leg motor neurons in thoracic ganglia. This neural circuit mediates the animal's escape behavior. The transcription factor Engrailed (En) is expressed only in the medially born sensory neurons, which suggested that it could work as a positional determinant of sensory neuron identity. Previously, we used double-stranded RNA interference to abolish En expression and found that the axonal arborization and synaptic outputs of an identified En-positive sensory neuron changed so that it came to resemble a nearby En-negative cell, which was itself unaffected. We thus demonstrated directly that En controls synaptic choice, as well as axon projections. Is escape behavior affected as a result of this miswiring? We showed recently that adult cockroaches keep each escape unpredictable by running along one of a set of preferred escape trajectories (ETs) at fixed angles from the direction of the threatening stimulus. The probability of selecting a particular ET is influenced by wind direction. In this present study, we show that early instar juvenile cockroaches also use those same ETs. En knock-out significantly perturbs the animals' perception of posterior wind, altering the choice of ETs to one more appropriate for anterior wind. This is the first time that it has been shown that knock-out of a transcription factor controlling synaptic connectivity can alter the perception of a directional stimulus

Workers need to question whether right to work laws arepromoting their rights or stripping them away

In March, Wisconsin controversially became the 25th state to adopt ‘right to work’ legislation which bans unions from collecting dues from non-unionized workers. Jonathan E. Booth looks at the history and background of right to work laws, which are often framed by those who support them as being pro-job and pro-growth. He argues that the evidence to support these claims is largely spurious, and that politicians, such as Wisconsin’s Governor, Scott Walker, have tended to use right to work laws in order to further their own political aspirations by weakening unions’ political power

Listen carefully: The voice of transgender employees is not being heard

Jonathan Booth, Assistant Professor of Organisational Behaviour and Human Resource Management, discusses why transgender voices in the workplace are not being heard and proposes solutions for fixing this issue

The Supreme Court's 'fair share' case is an existential threat to public sector unions. But it may force them to engage and embrace choice

The US Supreme Court recently heard oral arguments in the Janus v. AFSCME Council 31 case, which maintains that mandatory public sector union dues violate workers' First Amendment rights. Jonathan E. Booth argues that despite the case's free speech claims, such 'fair share' fees actually enhance the voice and representation of workers. He writes that if the Court finds against these fees, public sector unions may face declining memberships and falling incomes, which they could counter by increasing engagement with their members in order to prove their value

Union members are more likely to give to charity, and to give more when they do

While union membership has benefits to workers themselves, could these benefits have spill over effects that are also a boon to society? Jonathan Booth and Mark Williams look at the effects that union membership has on charitable giving, and find that being a union member makes people 5 percent more likely to give to charity, and also to give 30 percent more than non-union members. These findings, they argue, may have important implications for society in a time of declining union membership

Benefitting or suffering from a paradoxical leader? A self-regulation perspective

Why do followers’ reactions to perceived paradoxical leader behavior (PLB) differ? To answer this question, we draw from self-regulation theory and argue that making sense of a paradoxical leader’s seemingly contradictory behavior can pose a challenge for followers and requires specific cognitive traits and abilities that enable them to navigate such complex and dynamic environments. We propose that followers who lack these cognitive traits and related abilities find it more difficult to make sense of and navigate their paradoxical leader’s behavior, thereby perceiving them as behaviorally unpredictable. This, in turn, impairs followers’ self-regulation when working with such leaders, and leads to lower well-being. Conversely, followers endowed with appropriate cognitive traits can make sense of PLB and thrive in these environments. To test our propositions, we conducted two multi-wave field studies. In Study 1, we examine the role of followers’ trait cognitive flexibility in interpreting PLB; whereas Study 2 explores the role of followers’ trait self-regulation. The findings from these studies support our hypotheses, with an important implication: the efficacy of PLB may not only solely depend on a leader’s ability to enact these behaviors but also on their followers’ ability to interpret and make sense of them

How organisations can help their LGBTQI+ employees as they face divided experiences

LGBTQI+ people face divided experiences. They’re increasingly represented in media, and have more accessible information and wider access to legal marriage. At the same time, unprecedented criminalisation is excluding trans people from specific spaces and vital services. Jordana Moser, Jonathan E Booth and T Alexandra Beauregard describe the current state of play for LGBTQI+ inclusion and outline further steps that organisations can take to support their LGBTQI+ employees

Preventing Catastrophic Failure of Microfibrillar Adhesives in Compliant Systems Based on Statistical Analysis of Adhesive Strength

Adhesives based on fibrillar surface microstructures have shown great potential for handling applications requiring strong, reversible, and switchable adhesion. Recently, the importance of the statistical distribution of adhesive strength of individual fibrils in controlling the overall performance was revealed. Strength variations physically correspond to different interfacial defect sizes, which, among other factors, are related to surface roughness. For analysis of the strength distribution, Weibull's statistical theory of fracture was introduced. In this study, the importance of the statistical properties in controlling the stability of attachment is explored. Considering the compliance of the loading system, we develop a stability criterion based on the Weibull statistical parameters. It is shown that when the distribution in fibril adhesive strength is narrow, the global strength is higher but unstable detachment is more likely. Experimental variation of the loading system compliance for a specimen of differing statistical properties shows a transition to unstable detachment at low system stiffness, in good agreement with the theoretical stability map. This map serves to inform the design of gripper compliance, when coupled with statistical analysis of strength on the target surface of interest. Such a treatment could prevent catastrophic failure by spontaneous detachment of an object from an adhesive gripper. © 2021 The Authors. Published by American Chemical Society

Performance of Sustainable Road Pavements Founded on Clay Subgrades Treated with Eco-Friendly Cementitious Materials

Clays encountered during road construction are mostly weak and result in major pavement failures due to their low California bearing ratio (CBR) and high swelling potential. In this study, sustainable and eco-friendly waste materials including brick dust waste (BDW), ground granulated blastfurnance slag (GGBS), recycled plastic (RP) and recycled glass (RG) at varying proportions of 11.75% and 23.5% were used as partial replacement for cement and lime in clay treatment. After determining the water content by conducting Atterberg limit and compaction test, A CBR and swell characteristics of treated and untreated clay were also conducted. A road pavement design was conducted using the Design Manual for Road and Bridges (DMRB) as a guide to determine the performance of treated clay with varying CBR values. A road pavement failure analysis was also conducted to understand the defect formation within pavement structures supported by eco-friendly treated clay. The embodied carbon of treated clay was calculated and a life cycle cost analysis (LCCA) of flexible pavement with treated clay and road with imported materials was conducted. The results show a liquid limit of 131.26 and plastic limit of 28.74 for high plasticity index (clay 1) and liquid limit of 274.07 and a plastic limit of 45.38 for extremely high plasticity index (clay 2). An increase in CBR values from 8% and 9% to 57% and 97% with a reduction in swell values from 4.11% and 5.03% to 0.38% and 0.56% were recorded. This resulted in a reduction in pavement thickness and stresses within the road pavement leading to reduced susceptibility of the pavement to fatigue, rutting and permanent deformation. Very low embodied carbon was recorded for eco-friendly treated clay and a high life cycle cost (LCC) with clay removed and replaced with imported materials compared with clay treated using eco-friendly waste materials. The study concluded that carbon and overall construction costs can be reduced using waste materials in road construction. Owners and operators can save money when clay is treated and used in road construction instead of removing clay and replacing it with imported materials