Cellular Senescence in Livers from Children with End Stage Liver Disease

Senescent cells occur in adults with cirrhotic livers independent of the etiology. Aim: Investigate the presence rate of cellular senescence and expression of cell cycle check points in livers from children with end stage disease. staining occurred in the areas of ductular transformation and in the interlobular bile ducts.Cellular senescence in livers of children with end stage disease is associated with damage rather than corresponding to an age dependent phenomenon. Further studies are needed to support the hypothesis that these senescence markers correlate with disease progression

La Formación Docente en Argentina. El Proyecto “Polos de Desarrollo” a partir las narrativas de los actores

Throughout the history of the Argentine teacher training, many processes have gone through that have attempted to implement differentiated training projects with their own characterizations. It is possible to identify experiences that had different intentions of base, and varied intensities in their effects, but left traces that today survive in the institutions, in the provincial educational systems and in the subjects themselves. In this article we will especially recover the project “Poles de Desarrollo (2000-20001)” from the testimonies of the actors themselves and from the field of teacher training. We will use the biographical-narrative approach, since it gives us the possibility to reconstruct and reorganize the experience of the actors through the narrative, attributing meanings to the past with reference to the present and to the personal conceptions. This policy lacks visibility in Argentine academic productions and therefore constitutes the main object of our research.A lo largo de la historia de la formación docente argentina han transcurrido múltiples procesos que procuraron poner en marcha proyectos de formación diferenciados y con caracterizaciones propias. Pueden identificarse experiencias que tuvieron diferentes intenciones de base, e intensidades variadas en sus efectos, pero que dejaron huellas que hoy perviven en las instituciones, en los sistemas educativos provinciales y en los propios sujetos. En el presente artículo recuperaremos especialmente el proyecto “Polos de Desarrollo (2000-20001)” a partir de los testimonios de los propios actores y de referentes del campo de la formación docente. Utilizaremos el enfoque biográfico-narrativo, ya que nos otorga la posibilidad reconstruir y reorganizar la experiencia de los actores a través de la narrativa, atribuyendo significados al pasado en relación al presente y a las concepciones personales. Dicha política carece de visibilidad en las producciones académicas argentinas y por tanto configura el objeto principal de nuestra investigación

Cartografías normativas de la Formación Docente Argentina (1999-2015). Resemantizando sentidos políticos en tiempos de esperanza

Not only does the political, social, and economic conjuncture play a significant role in structural issues oftheArgentine education system and its teacher education subset, butit also has influence over the cultural and pedagogical dimensiones deployed in educational environments. We consider, within this context, imperative to revisit the policies, regulations, and legislation that forged, in the first years of the new millennium, the field of teacher education in our country. We will critically look back to reprofile them and to assume a positive outlook for the future, so as to raise hope amidst a critical present.In this paper,therefore,wewilltry to briefly inhabitthe modifications and political bets made in the turn of the century, and we will describe the potentialities of and the tensions generated by the enactment oftheNationalEducationLaw,Educational Financing Law and the subsequent creation of the National Institution for Teacher Education, with the understanding that these measures, and the projects launched within them, were the last policies concerned with the field of teacher education that presented real possibilities for its improvement andgrowth.Inshort,we tackle the challenge of exploring critically the legal andregulatory backbones in the teacher education system up to the year 2015 with the purpose of reshaping them in times of hope and change.La coyuntura política, social y económica actual incide significativamente no solo en cuestiones estructurales del sistema educativo argentino y del subnivel de la formación docente, sino que influye en las dimensiones culturales y pedagógicas que en los cotidianos educativos se despliegan. En este contexto, consideramos que se vuelve nodal revisitar las políticas, las normativas y la propia legislación que forjaron, en los primeros años del nuevo milenio el campo la formación de maestros y profesores en nuestro país. Volveremos críticamente sobre ellos para resemantizarlos y asumir una mirada prospectiva hacia el futuro que brinde esperanza en medio de la crisis actual. En este artículo, por tanto, habitaremos brevemente las modificaciones y apuestas políticas acontecidas en el cambio de siglo y describiremos las potencialidades y tensiones que asumió la implementación de Ley de Educación Nacional, la Ley de Financiamiento Educativo y la consecuente creación del Instituto Nacional de Formación Docente, entendiendo que éstas disposiciones y los proyectos que en su interior se desplegaron, fueron las últimas políticas en materia de formación docente que brindaron al ámbito formador condiciones de posibilidad para su enriquecimiento y mejora. Asumimos, en definitiva, el desafío de explorar críticamente el esqueleto legal y normativo del subsistema formador de docentes hasta el año 2015 para resemantizarlos en tiempos de esperanza y de cambios.

Archipiélagos narrativos de una epifanía centenaria. La reforma universitaria desde las voces de los académicos

The university reform of 1918 became the passing of the years in a true centennial epiphany. Its epiphanic character is based on the political, institutional and pedagogical break that the reformist movement meant for the university system as a whole, and its permanent commemoration in the path of life of those who travel the universities and resignify day by day the historical legacy of that process that transcended the Latin American borders. The reform becomes centennial epiphany in the sense of milestone and footprint that, a hundred years of its genesis, invites us to reflect and resignify its principles in light of the new challenges of contemporary society. In this article, we will approach this university reform in a current perspective based on the narratives and narratives of Argentinean academics with a long career in higher education. We will inhabit these narrative archipelagos using the focus of (auto) biographical-narrative research, since, when narrating, the subjects create and recreate their experiences allowing crystallize the senses that they give to their vital processes in relation to the university experience and the legacy of the centennial reform. Reform that in the words of one interviewee became, “heart of the university system” for the region.La reforma universitaria de 1918 se convirtió en el transcurrir de los años en una verdadera epifanía centenaria. Su carácter epifánico se funda en el quiebre político, institucional y pedagógico que significó el movimiento reformista para el sistema universitario en su conjunto, y su conmemoración permanente en la trayectoria de vida de quienes transitan las universidades y resignifican día a día el legado histórico de aquel proceso que trascendió las fronteras latinoamericanas. La reforma se vuelve epifanía centenaria en el sentido de hito y huella que, a cien años de su génesis, nos invita a reflexionar y resignificar sus principios a la luz de los nuevos desafíos de la sociedad contemporánea. En este artículo abordaremos dicha reforma universitaria en perspectiva actual a partir de relatos y narrativas de académicos argentinos de extensa trayectoria en el nivel superior. Habitaremos dichos archipiélagos narrativos valiéndonos del enfoque de investigación (auto)biográfico-narrativo, ya que, al narrar, los sujetos crean y recrean sus experiencias permitiendo cristalizar los sentidos que ellos mismos le otorgan a sus procesos vitales en relación a la experiencia universitaria y al legado de la reforma centenaria. Reforma que en palabras de un entrevistado se volvió, “corazón del sistema universitario” para la región

Correction: Cellular Senescence in Livers from Children with End Stage Liver Disease

Correction

Cellular Senescence in Livers from Children with End Stage Liver Disease

BackgroundSenescent cells occur in adults with cirrhotic livers independent of the etiology. Aim: Investigate the presence rate of cellular senescence and expression of cell cycle check points in livers from children with end stage disease.Methodology/Principal FindingsLivers of five children aged three years or less undergoing liver transplantation due to tyrosinemia (n = 1), biliary atresia (n = 2), or fulminant hepatitis (n = 2) were analyzed for senescence associated β-galactosidase (SA-βgal) activity and p16INK4a, p21cip1 and p53. All livers displayed positive cellular staining for SA-βgal in the canals of Hering and interlobular biliary ducts. In the presence of cirrhosis (3/5 cases) SA-βgal was found at the cholangioles and hepatocytes surrounding the regenerative nodules. Children with fulminant hepatic failure without cirrhosis had significant ductular transformation with intense SA-βgal activity. No SA-βgal activity was evident in the fibrous septa. Staining for p53 had a similar distribution to that observed for SA-βgal. Staining for p16INK4a and p21cip1 was positive in the explanted liver of the patient with tyrosinemia, in the hepatocytes, the canals of Hering, cholangioles and interlobular bile ducts. In the livers with fulminant hepatitis, p21cip1 staining occurred in the areas of ductular transformation and in the interlobular bile ducts.Conclusions/SignificanceCellular senescence in livers of children with end stage disease is associated with damage rather than corresponding to an age dependent phenomenon. Further studies are needed to support the hypothesis that these senescence markers correlate with disease progression