Measurements of noise in Josephson-effect mixers

We present new heterodyne receiver results obtained at 100 GHz using resistively-shunted Nb and NbN tunnel junctions. In addition, we have carried out accurate measurements of the available noise power of these devices at the L-band (1.5 GHz) IF frequency. Both the heterodyne and the output noise measurements show that the noise of these devices can be a factor of five or more higher than that predicted by the simple current-biased RSJ model. The noise approaches the appropriate thermal or thermal and shot noise limits for bias voltages where the nonlinearity is not strong (i.e., V>ICRN), but as expected from the RSJ model, can be significantly higher at the low voltages where the mixers are typically biased. The bias voltage dependence of the noise shows structure which is associated with resonances in the RF embedding circuit. Surprisingly, we find that changes in the high-frequency (100 GHz) impedance presented to the junction can dramatically affect the magnitude and voltage dependence of the low-frequency (1.5 GHz) noise. This emphasizes the necessity of very closely matching the junction to free space over a wide frequency range

Characterization of low-noise quasi-optical SIS mixers for the submillimeter band

We report on the development of low-noise quasi-optical SIS mixers for the frequency range 400-850 GHz. The mixers utilize twin-slot antennas, two-junction tuning circuits, and Nb-trilayer junctions. Fourier-transform spectrometry has been used to verify that the frequency response of the devices is well predicted by computer simulations. The 400-850 GHz frequency band can be covered with four separate fixed-tuned mixers. We measure uncorrected double-sideband receiver noise temperatures around 5hν/kB to 700 GHz, and better than 540 K at 808 GHz. These results are among the best reported to date for broadband heterodyne receivers

A multiscale view on inverse statistics and gain/loss asymmetry in financial time series

Researchers have studied the first passage time of financial time series and observed that the smallest time interval needed for a stock index to move a given distance is typically shorter for negative than for positive price movements. The same is not observed for the index constituents, the individual stocks. We use the discrete wavelet transform to illustrate that this is a long rather than short time scale phenomenon -- if enough low frequency content of the price process is removed, the asymmetry disappears. We also propose a new model, which explain the asymmetry by prolonged, correlated down movements of individual stocks

Selective autonomic stimulation of the AV node fat pad to control rapid post-operative atrial arrhythmias.

Junctional ectopic tachycardia (JET) and atrial fibrillation (AF) occur in patients recovering from open-heart surgery (OHS). Pharmacologic treatment is used for the control of post-operative atrial arrhythmias (POAA), but is associated with side effects. There is a need for a reversible, modulated solution to rate control. We propose a non-pharmacologic technique that can modulate AV nodal conduction in a selective fashion. Ten mongrel dogs underwent OHS. Stimulation of the anterior right (AR) and inferior right (IR) fat pad (FP) was done using a 7-pole electrode. The IR was more effective in slowing the ventricular rate (VR) to AF (52 +/- 20 vs. 15 +/- 10%, p = 0.003) and JET (12 +/- 7 vs. 0 +/- 0%, p = 0.02). Selective site stimulation within a FP region could augment the effect of stimulation during AF (57 +/- 20% (maximum effect) vs. 0 +/- 0% (minimum effect),

Validation of a screening method for the detection of colistin-resistant \u3ci\u3eE. coli\u3c/i\u3e containing mcr-1 in feral swine feces

A method was developed and validated for the detection of colistin-resistant Escherichia coli containing mcr-1 in the feces of feral swine. Following optimization of an enrichment method using EC broth supplemented with colistin (1 μg/mL) and vancomycin (8 μg/mL), aliquots derived from 100 feral swine fecal samples were spiked with of one of five different mcr-1 positive E. coli strains (between 100 and 104 CFU/g), for a total of 1110 samples tested. Enrichments were then screened using a simple boil-prep and a previously developed real-time PCR assay for mcr-1 detection. The sensitivity of the method was determined in swine feces, with mcr-1 E. coli inocula of 0.1–9.99 CFU/g (n=340), 10–49.99 CFU/g (n=170), 50–99 CFU/g (n=255), 100–149 CFU/g (n=60), and 200–2200 CFU/g (n=175), which were detected with 32%, 72%, 88%, 95%, and 98% accuracy, respectively. Uninoculated controls (n = 100) were negative for mcr-1 following enrichment

Perceptions and behaviours of infectious diseases physicians when managing urinary tract infections due to MDR organisms

Objectives The objective of this study was to attain a better understanding of infectious diseases (ID) physicians' experience with MDR organism (MDRO) urinary tract infections (UTIs) by means of a survey on disease perception, diagnostic management and treatment preferences. Methods A nine-question survey was developed and distributed to members of the North American Emerging Infections Network (EIN) in September 2013. Results Seven hundred and fourteen out of 1461 EIN members responded to the survey (49%). The responses of 603 responders were studied. Most providers perceived an increase in the incidence of MDRO UTIs over the past 3 years (75% of adult ID responders and 63% of paediatric ID responders). One hundred and thirty-four (22%) responders prefer intravenous over oral administration of antimicrobials when both are available, 171 (28%) prefer longer durations of therapy when comparing an MDRO with a susceptible isolate of the same species and 142 (24%) order a repeat urine culture as ‘proof of cure' after treating an MDRO UTI. Nevertheless, 530 (88%) responders perceived MDRO UTIs to be of similar severity as non-MDRO UTIs. Fifty-five percent of providers prescribed fosfomycin for MDRO UTI at least once; the most common prescribing pattern (among a wide spectrum of approaches) was a single dose (16%). Conclusions Future studies on MDRO UTIs should clarify the role of resistance in patient outcomes and the comparative efficacy of different antimicrobials. Of particular interest is fosfomycin, which is unrelated to other antibiotic classes and may take a more prominent role in treating MDRO cystiti

Two-junction tuning circuits for submillimeter SIS mixers

The capacitance of superconducting tunnel junctions can seriously degrade the performance of quasiparticle (SIS) mixers operating in the submillimeter band, so it is essential to provide a circuit for tuning out this capacitance at the operating frequency. In this article, we present two new tuning circuits for SIS mixers which use a pair of SIS junctions connected by an inductance. Compared to previously proposed tuning circuits, ours have a broader bandwidth, are easier to scale to higher frequencies, and may be easier to fabricate. We have constructed quasi-optical mixers which employ these tuning circuits, using Nb/Al-Oxide/Nb SIS junctions defined by optical lithography. The performance of these devices is excellent, giving receiver noise temperatures of 113 K (DSB) at 490 GHz and 230 K DSB at 612 GHz. In addition to demonstrating the effectiveness of our tuning circuit, these results show that quasi-optical mixers can be competitive with or superior to waveguide mixers at submillimeter wavelengths. The mixers continue to perform well at frequencies up to 672 GHz, which is about 95% of the Nb gap frequency

Gulls as Sources of Environmental Contamination by Colistin-resistant Bacteria

In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug resistant bacterial infections in humans. Since then, mcr-1 was found in other human and animal populations, including wild gulls. Because gulls could disseminate the mcr-1 gene, we conducted an experiment to assess whether gulls are readily colonized with mcr-1 positive E. coli, their shedding patterns, transmission among conspecifics, and environmental deposition. Shedding of mcr-1 E. coli by small gull flocks followed a lognormal curve and gulls shed one strain \u3e101 log10 CFU/g in their feces for 16.4 days, which persisted in the environment for 29.3 days. Because gulls are mobile and can shed antimicrobial-resistant bacteria for extended periods, gulls may facilitate transmission of mcr-1 positive E. coli to humans and livestock through fecal contamination of water, public areas and agricultural operations

Tracking Scheme Dependence of Simulated Tropical Cyclone Response to Idealized Climate Simulations

Future tropical cyclone activity is a topic of great scientific and societal interest. In the absence of a climate theory of tropical cyclogenesis, general circulation models are the primary tool available for investigating the issue. However, the identification of tropical cyclones in model data at moderate resolution is complex, and numerous schemes have been developed for their detection. The influence of different tracking schemes on detected tropical cyclone activity and responses in the Hurricane Working Group experiments is examined herein. These are idealized atmospheric general circulation model experiments aimed at determining and distinguishing the effects of increased sea surface temperature and other increased CO2 effects on tropical cyclone activity. Two tracking schemes are applied to these data and the tracks provided by each modeling group are analyzed. The results herein indicate moderate agreement between the different tracking methods, with some models and experiments showing better agreement across schemes than others. When comparing responses between experiments, it is found that much of the disagreement between schemes is due to differences in duration, wind speed, and formation-latitude thresholds. After homogenization in these thresholds, agreement between different tracking methods is improved. However, much disagreement remains, accountable for by more fundamental differences between the tracking schemes. The results indicate that sensitivity testing and selection of objective thresholds are the key factors in obtaining meaningful, reproducible results when tracking tropical cyclones in climate model data at these resolutions, but that more fundamental differences between tracking methods can also have a significant impact on the responses in activity detected