Plants are technologies

Histories of Technology, the Environment and Modern Britain brings together historians with a wide range of interests to take a uniquely wide-lens view of how technology and the environment have been intimately and irreversibly entangled in Britain over the last 300 years. It combines, for the first time, two perspectives with much to say about Britain since the industrial revolution: the history of technology and environmental history. Technologies are modified environments, just as nature is to varying extents engineered. Furthermore, technologies and our living and non-living environment are both predominant material forms of organisation – and self-organisation – that surround and make us. Both have changed over time, in intersecting ways. Technologies discussed in the collection include bulldozers, submarine cables, automobiles, flood barriers, medical devices, museum displays and biotechnologies. Environments investigated include bogs, cities, farms, places of natural beauty and pollution, land and sea. The book explores this diversity but also offers an integrated framework for understanding these intersections

Indigenous Australians and competition and consumer issues: A review of the literature and an annotated bibliography

This working paper is based on a literature search conducted to identify and review relevant Australian and overseas research that is of relevance to Indigenous competition and consumer protection matters. The focus of the literature search has been on matters of relevance to Indigenous communities throughout Australia related to the Trade Practices Act 1974 (TPA). Results of the literature search suggest that most research conducted to date has focused on issues associated with Indigenous community stores and consumer banking. In addition, the geographic focus of past research has been predominantly on remote and regional Australia, areas where the structural impediments associated with remoteness may impede competition. Further, although the research has included some discussion of competition in Indigenous communities, it has mainly focused on consumer issues

Influence of Beginning Body Condition Scores on Net Returns From Feeding Cull Cows

The impact of beginning body condition scores on returns from feeding cull cows was investigated in a two year experiment. In each of two culling years, physical performance data and financial data were measured at approximately monthly intervals for culls on pasture versus dry lot. Specifically, data was collected for cows culled in October 2007 and held through April 2008 and for cows culled in October 2008 and held through March 2009. We examine the sensitivity of net returns relative to the choice of body condition score as a sorting trigger for heavy versus thin cows. In this two year study, while a pasture system was generally more profitable than a drylot system, thin cows were typically more profitable than cows with higher BCS, regardless of the feeding system. The importance of the sorting criteria is highlighted in year two. Using the lower BCS criteria for sorting is the only scenario that generates positive net returns, albeit small. Thus, decisions regarding cull cow retention and feeding should consider body condition scores.Agricultural and Food Policy,

Management Production Systems and Timing Strategies for Cull Cows

Replaced with revised version of paper 06/04/09.Cattle, cull cows, management, marketing, production systems, timing, Farm Management, Marketing,

Enantioselective Ruthenium-Catalyzed Ring-Closing Metathesis

The first enantioselective ruthenium olefin metathesis catalysts have been prepared, and high enantiomeric excesses (up to 90%) are observed in the desymmetrization of achiral trienes. A model consistent with the stereochemical outcome of the reactions is described and suggests side-on olefin binding and reorganization of the halide ligands

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17

Background: studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking.Objective: to characterize the phenotype of lung macrophages from asthmatic patients in relation to disease severity and treatment.Methods: M2 biomarkers were first identified by using MDMs exposed to T(H)2 cytokines and then used to phenotype sputum and bronchoalveolar lavage (BAL) macrophages from 12 healthy control subjects, 12 patients with mild asthma, and 14 patients with moderate asthma and to assess the effects of corticosteroids and phosphatidylinositol 3-kinase (PI3K) inhibitors.Results: sputum macrophages from asthmatic patients expressed significantly more CCL17 mRNA but less CD163 than macrophages from healthy subjects. However, none of the other M2 biomarkers were differentially expressed in asthmatic patients, and ex vivo BAL cells spontaneously produced similar amounts of M2 cytokines/chemokines (IL-10, CCL17, and CCL22). CCL17 mRNA overexpression correlated weakly but significantly with sputum eosinophilia (P = .0252) and was also observed in macrophages from patients with moderate asthma treated with inhaled steroids, suggesting relative insensitivity to inhibition by corticosteroids. The PI3K inhibitor LY294002 inhibited basal CCL17 release from BAL cells and IL-4-stimulated release from MDMs.Conclusions: this study does not support the existence in human asthma of the full M2 phenotype described to date but points to upregulation of CCL17 in both patients with mild and those with moderate asthma, providing a further source for this ligand of CCR4(+) cells that contributes to airways inflammation. CCL17 expression is corticosteroid resistant but suppressed by PI3K enzyme inhibitors<br/

Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants

Background: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases. Objective: we tested whether any association with APOE e4 status on cognitive ability was larger in older ages or in those with cardiometabolic diseases. Subjects: UK Biobank includes over 500,000 middle- and older aged adults who have undergone detailed medical and cognitive phenotypic assessment. Around 150,000 currently have genetic data. We examined 111,739 participants with complete genetic and cognitive data. Methods: baseline cognitive data relating to information processing speed, memory and reasoning were used. We tested for interactions with age and with the presence versus absence of type 2 diabetes (T2D), coronary artery disease (CAD) and hypertension. Results: in several instances, APOE e4 dosage interacted with older age and disease presence to affect cognitive scores. When adjusted for potentially confounding variables, there was no APOE e4 effect on the outcome variables. Conclusions: future research in large independent cohorts should continue to investigate this important question, which has potential implications for aetiology related to dementia and cognitive impairment

Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior

Imprinted genes are expressed from one parental allele only as a consequence of epigenetic events that take place in the mammalian germ line and are thought to have evolved through intra-genomic conflict between parental alleles. We demonstrate, for the first time, oppositional effects of imprinted genes on brain and behavior. Specifically, here we show that mice lacking paternal Grb10 make fewer impulsive choices, with no dissociable effects on a separate measure of impulsive action. Taken together with previous work showing that mice lacking maternal Nesp55 make more impulsive choices this suggests that impulsive choice behavior is a substrate for the action of genomic imprinting. Moreover, the contrasting effect of these two genes suggests impulsive choices are subject to intra-genomic conflict and that maternal and paternal interests pull this behavior in opposite directions. Finally, these data may also indicate that an imbalance in expression of imprinted genes contributes to pathological conditions such as gambling and drug addiction, where impulsive behavior becomes maladaptive