What kind of theory for anthropological demography?

This paper argues that demographic anthropology has, for most part, imported rather than exported theory. Yet, the discipline has the potential to generate important rethinking of population, culture, and their interaction. After discussing the state of the field and the challenges that must be faced in developing new theoretical approaches in demographic anthropology, the paper suggests a framework for research based on the related ideas of the "demographic conjuncture" and "construal."anthropological demography, culture and population, demographic anthropology, social theory

Hiding or hospitalising? On dilemmas of pregnancy management in East Cameroon

Current international debates and policies on safe motherhood mainly propose biomedical interventions to reduce the risks during pregnancy and delivery. Yet, the conceptualisations of risk that underlie this framework may not correspond with local perceptions of reproductive dangers; consequently, hospital services may remain underutilised. Inspired by a growing body of anthropological literature exploring local fertility-related fears, and drawing on 15 months of fieldwork, this paper describes ideas about risky reproduction and practices of pregnancy protection in a Cameroonian village. It shows that social and supernatural threats to fertility are deemed more significant than the physical threats of fertility stressed at the (inter)national level. To protect their pregnancies from those social and supernatural influences, however, women take very physical measures. It is in this respect that biomedical interventions, physical in their very nature, do connect to local methods of pregnancy management. Furthermore, some pregnant women purposefully deploy hospital care in an attempt to reduce relational uncertainties. Explicit attention to the intersections of the social and the physical, and of the supernatural and the biomedical, furthers anthropological knowledge on fertility management and offers a starting point for more culturally sensitive safe motherhood interventions

Measuring Five Dimensions of Religiosity Across Adolescence

This paper theorizes and tests a latent variable model of adolescent religiosity in which five dimensions of religiosity are interrelated: religious beliefs, religious exclusivity, external religiosity, private practice, and religious salience. Research often theorizes overlapping and independent influences of single items or dimensions of religiosity on outcomes such as adolescent sexual behavior, but rarely operationalizes the dimensions in a measurement model accounting for their associations with each other and across time. We use longitudinal structural equation modeling (SEM) with latent variables to analyze data from two waves of the National Study of Youth and Religion. We test our hypothesized measurement model as compared to four alternate measurement models and find that our proposed model maintains superior fit. We then discuss the associations between the five dimensions of religiosity we measure and how these change over time. Our findings suggest how future research might better operationalize multiple dimensions of religiosity in studies of the influence of religion in adolescence

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

What kind of theory for anthropological demography?

This paper argues that demographic anthropology has, for most part, imported rather than exported theory. Yet, the discipline has the potential to generate important rethinking of population, culture, and their interaction. After discussing the state of the field and the challenges that must be faced in developing new theoretical approaches in demographic anthropology, the paper suggests a framework for research based on the related ideas of the "demographic conjuncture" and "construal.

On the Modernity of Traditional Contraception: Time and the Social Context of Fertility

Many studies of fertility implicitly equate temporal management, biomedical contraception, and "modernity" on the one hand, and "tradition," the lack of intentional timing, and uncontrolled fertility on the other. This article questions that equation, focusing on the widespread use of periodic abstinence in southern Cameroon. Drawing on field data and the Cameroon Demographic and Health Survey, the article investigates how local concepts of timing shape both contraceptive choice and the evaluation of methods as "modern" or "traditional." Cameroonian women prefer periodic abstinence because they perceive it as "modern," a modernity tied both to the social context in which it is taught and to its unique temporal form. By contrast, Depo-Provera, pills, and the IUD are seen as less-than-modern, because they are less exigent of temporal control. The reliance on a behavioral, rather than technological, contraceptive method parallels the experience of the European fertility transition. Cameroonian women draw on a complex social repertoire in making contraceptive choices; methods are preferred or rejected not only on the basis of their efficacy in averting pregnancy, but also because of their correspondence to models of legitimate social action. Reproductive practices may have social motivations that are unrelated to fertility per se. Copyright 2002 by The Population Council, Inc..