Repeatability of fractional flow reserve despite variations in systemic and coronary hemodynamics

Objectives This study classified and quantified the variation in fractional flow reserve (FFR) due to fluctuations in systemic and coronary hemodynamics during intravenous adenosine infusion. Background Although FFR has become a key invasive tool to guide treatment, questions remain regarding its repeatability and stability during intravenous adenosine infusion because of systemic effects that can alter driving pressure and heart rate. Methods We reanalyzed data from the VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice) study, which enrolled consecutive patients who were infused with intravenous adenosine at 140 μg/kg/min and measured FFR twice. Raw phasic pressure tracings from the aorta (Pa) and distal coronary artery (Pd) were transformed into moving averages of Pd/Pa. Visual analysis grouped Pd/Pa curves into patterns of similar response. Quantitative analysis of the Pd/Pa curves identified the “smart minimum” FFR using a novel algorithm, which was compared with human core laboratory analysis. Results A total of 190 complete pairs came from 206 patients after exclusions. Visual analysis revealed 3 Pd/Pa patterns: “classic” (sigmoid) in 57%, “humped” (sigmoid with superimposed bumps of varying height) in 39%, and “unusual” (no pattern) in 4%. The Pd/Pa pattern repeated itself in 67% of patient pairs. Despite variability of Pd/Pa during the hyperemic period, the “smart minimum” FFR demonstrated excellent repeatability (bias −0.001, SD 0.018, paired p = 0.93, r2 = 98.2%, coefficient of variation = 2.5%). Our algorithm produced FFR values not significantly different from human core laboratory analysis (paired p = 0.43 vs. VERIFY; p = 0.34 vs. RESOLVE). Conclusions Intravenous adenosine produced 3 general patterns of Pd/Pa response, with associated variability in aortic and coronary pressure and heart rate during the hyperemic period. Nevertheless, FFR – when chosen appropriately – proved to be a highly reproducible value. Therefore, operators can confidently select the “smart minimum” FFR for patient care. Our results suggest that this selection process can be automated, yet comparable to human core laboratory analysis

Interaction of Natural Organic Matter with Layered Minerals: Recent Developments in Computational Methods at the Nanoscale

The role of mineral surfaces in the adsorption, transport, formation, and degradation of natural organic matter (NOM) in the biosphere remains an active research area owing to the difficulties in identifying proper working models of both NOM and mineral phases present in the environment. The variety of aqueous chemistries encountered in the subsurface (e.g., oxic vs. anoxic, variable pH) further complicate this field of study. Recently, the advent of nanoscale probes such as X-ray adsorption spectroscopy and surface vibrational spectroscopy applied to study such complicated interfacial systems have enabled new insight into NOM-mineral interfaces. Additionally, due to increasing capabilities in computational chemistry, it is now possible to simulate molecular processes of NOM at multiple scales, from quantum methods for electron transfer to classical methods for folding and adsorption of macroparticles. In this review, we present recent developments in interfacial properties of NOM adsorbed on mineral surfaces from a computational point of view that is informed by recent experiments

Broadleaf weed control in chickpea (Cicer arietinum) and lentil (Lens culinaris) with fall application of pursuit

Non-Peer ReviewedBroadleaf weed control options in chickpea and lentil are very limited. Preliminary trials found that spring applied Pursuit at rates from 0.25X to 0.5X resulted in severe injury to chickpea in some years. The objective of these trials was to evaluate fall application of Pursuit in chickpea and lentil, at rates from 0.25X to 0.5X, for both crop tolerance and weed control efficacy. A 4-replicate trial was set up at Saskatoon, Sask. in 2000, 2001 and 2002 and at Scott, Sask. and Swift Current, Sask. in 2002. Pursuit was surface applied, with no incorporation, in the fall, at rates of 0.25X, 0.33X, 0.4X and 0.5X. Edge (2000) or Poast Ultra (2001, 2002) were applied to improve grassy weed control. The trials were direct seeded with low disturbance openers. There was excellent crop tolerance to fall applications of Pursuit in both chickpea and lentil at all location-years. Some visual crop injury was evident at the higher rates of Pursuit; however, yield was not reduced. Broadleaf weed control was inconsistent at the 0.25X rate. Rates higher than 0.33X rates resulted in excellent control of stinkweed (Thlaspi arvense L.), wild mustard (Sinapsis arvensis L.), wild buckwheat (Polygonum convolvulus L.), lamb’s-quarters (Chenopodium album L.), redroot pigweed (Amaranthus retroflexus L.), Russian thistle (Salsola kali L.) and cleavers (Galium aparine L.) at all location-years. When compared to a post-emergence application of Sencor, fall applied Pursuit at 0.33X to 0.4X rates resulted in similar to 20% higher seed yields in lentil and chickpea, respectively. Fall applied Pursuit at 0.33X to 0.4X rate resulted in consistent broadleaf weed control, low crop injury, and high crop yield

Phasic pressure measurements for coronary and valvular interventions using fluid-filled catheters: Errors, automated correction, and clinical implications.

We sought to develop an automatic method for correcting common errors in phasic pressure tracings for physiology-guided interventions on coronary and valvular stenosis. Effective coronary and valvular interventions rely on accurate hemodynamic assessment. Phasic (subcycle) indexes remain intrinsic to valvular stenosis and are emerging for coronary stenosis. Errors, corrections, and clinical implications of fluid-filled catheter phasic pressure assessments have not been assessed in the current era of ubiquitous, high-fidelity pressure wire sensors. We recruited patients undergoing invasive coronary physiology assessment. Phasic aortic pressure signals were recorded simultaneously using a fluid-filled guide catheter and 0.014″ pressure wire before and after standard calibration as well as after pullback. We included additional subjects undergoing hemodynamic assessment before and after transcatheter aortic valve implantation. Using the pressure wire as reference standard, we developed an automatic algorithm to match phasic pressures. Removing pressure offset and temporal shift produced the largest improvements in root mean square (RMS) error between catheter and pressure wire signals. However, further optimization <1 mmHg RMS error was possible by accounting for differential gain and the oscillatory behavior of the fluid-filled guide. The impact of correction was larger for subcycle (like systole or diastole) versus whole-cycle metrics, indicating a key role for valvular stenosis and emerging coronary pressure ratios. When calibrating phasic aortic pressure signals using a pressure wire, correction requires these parameters: offset, timing, gain, and oscillations (frequency and damping factor). Automatically eliminating common errors may improve some clinical decisions regarding physiology-based intervention

An assessment of polybrominated diphenyl ethers (PBDEs) in sediments and bivalves of the U.S. coastal zone

NOAA’s Mussel Watch Program was designed to monitor the status and trends of chemical contamination of U.S. coastal waters, including the Great Lakes. The Program began in 1986 and is one of the longest running, continuous coastal monitoring programs that is national in scope. NOAA established Mussel Watch in response to a legislative mandate under Section 202 of Title II of the Marine Protection, Research and Sanctuaries Act (MPRSA) (33 USC 1442). In addition to monitoring contaminants throughout the Nation’s coastal shores, Mussel Watch stores samples in a specimen bank so that trends can be determined retrospectively for new and emerging contaminants of concern. In recent years, flame retardant chemicals, known as polybrominated diphenyl ethers (PBDEs), have generated international concern over their widespread distribution in the environment, their potential to bioaccumulate in humans and wildlife, and concern for suspected adverse human health effects. The Mussel Watch Program, with additional funding provided by NOAA’s Oceans and Human Health Initiative, conducted a study of PBDEs in bivalve tissues and sediments. This report, which represents the first national assessment of PBDEs in the U.S. coastal zone, shows that they are widely distributed. PBDE concentrations in both sediment and bivalve tissue correlate with human population density along the U.S. coastline. The national and watershed perspectives given in this report are intended to support research, local monitoring, resource management, and policy decisions concerning these contaminants

Normal faulting in the Simav graben of western Turkey reassessed with calibrated earthquake relocations

Western Turkey has a long history of large earthquakes, but the responsible faults are poorly characterized. Here we reassess the past half century of instrumental earthquakes in the Simav-Gediz region, starting with the 19 May 2011 Simav earthquake (Mw 5.9), which we image using interferometric synthetic aperture radar and regional and teleseismic waveforms. This event ruptured a steep, planar normal fault centered at 7–9 km depth but failed to break the surface. However, relocated main shock and aftershock hypocenters occurred beneath the main slip plane at 10–22 km depth, implying rupture initiation in areas of low coseismic slip. These calibrated modern earthquakes provide the impetus to relocate and reassess older instrumental events in the region. Aftershocks of the 1970 Gediz earthquake (Mw 7.1) form a narrow band, inconsistent with source models that invoke low-angle detachment faulting, and may include events triggered dynamically by the unilateral main shock rupture. Epicenters of the 1969 Demirci earthquakes (Mw 5.9, 6.0) are more consistent with slip on the south dipping Akdağ fault than the larger, north dipping Simav fault. A counterintuitive aspect of recent seismicity across our study area is that the largest event (Mw 7.1) occurred in an area of slower extension and indistinct surface faulting, yet ruptured the surface, while recent earthquakes in the well-defined and more rapidly extending Simav graben are smaller (Mw <6.0) and failed to produce surface breaks. Though our study area bounds a major metamorphic core complex, there is no evidence for involvement of low-angle normal faulting in any of the recent large earthquakes

Effect of timing of isoxaflutole application on weed control in desi chickpea (Cicer arietinum)

Non-Peer Reviewe

Interactions of soil residual ALS inhibiting herbicides

Non-Peer ReviewedALS inhibiting herbicides exhibit high bioactivity at low concentrations and may persist in the soil. To examine possible interactions between two different residues present together in the soil, field and lab tests were performed in three contrasting Saskatchewan soils. Field plots using Roundup Ready canola were used to assess residual effects of combinations of ALS inhibiting herbicides applied to peas and wheat in the previous two years. A root length inhibition bioassay based on oriental mustard was used to test for residual herbicide phytotoxicity in samples of soil from field and lab-spiked soils from the three study sites. The field plots were sprayed initially with imazamox/imazethapyr, and followed by imazamethabenz, flucarbazone-sodium, sulfosulfuron, or florasulam in the second growing season. Soil samples were taken from the plots after the second growing season for the bioassay test. To determine the interactions (antagonistic, additive, or synergistic) between the herbicides investigated, Colby’s equation was applied to the bioassay results. In field samples, the results to date have indicated additive and potential synergistic interactions for the same herbicide combinations in different soils

Effects of Molybdenum Supplementation on Performance of Forage‐fed SteersReceiving High‐sulfur Water

There has been on‐going research in the area of the consumption of high‐sulfur (S) water by steers grazing rangeland as well as forage‐fed steers in a feedlot setting. During the summer of 2009, a trial was conducted on the effects of high‐S water in finishing steers supplemented with molybdenum (Mo). The main purpose of the research was to gather data that may aid in the formulation of a supplement to counteract the negative effects of high‐S water consumed by ruminant livestock species in areas where sulfur concentration in water sources is a risk to animal health and performance. The specific focus of this trial was to determine whether the feeding of supplemental Mo would improve animal health and performance by decreasing the formation of hydrogen sulfide gas (H2S) in the rumen. Yearling steers (n=96) were used for a 56‐d trial. The trial consisted of 3 treatment groups; a low‐S water group and two high‐S water groups. One high‐S water treatment group received the same pellet that the low‐S group was given and the other high‐S water treatment group received a pellet with supplemental Mo included. Rumen gas cap H2S was collected on d ‐1, 29 and 57. Weights were recorded on d ‐2, ‐1, 29, 56 and 57. There were no differences between treatments in water intake (P= 0.719), but feed intake was reduced in the steers receiving the supplemental Mo (P \u3c 0.001). There was a significant difference in ruminal H2S due to treatment (P= 0.014), with higher ruminal H2S in the steers receiving the supplemental Mo. Steers receiving the Mo supplement had lower ADG than steers in the other treatments (P= 0.009). Throughout the duration of the trial, two steers were removed from the trial due to advanced symptoms of sulfur‐induced PEM (sPEM) from the high‐S treatment with no supplemental M

In search of new herbicide chemistries for the prairies

Non-Peer ReviewedThere are a limited of herbicide groups for use in western Canada so there is a need introduce different modes of action to manage herbicide resistant weeds. In addition, many broadleaf crops such as chickpea have limited broadleaf weed control options. Sulfentrazone, a Group 14 PPO inhibitor has been screened in a number of broadleaf crops. Chickpea has exhibited excellent tolerance to sulfentrazone, while the tolerance of other broadleaf crops can be summarized as follows: sunflower and fababean (fair to good); field pea, and narrow-leaved lupin (fair); dry bean (poor) and lentil (very poor). Isoxaflutole is a Group 27 carotenoid biosynthesis inhibitor that may have potential for use in chickpea, tame buckwheat, and narrow-leaved lupin. Sulfentrazone effectively controls many broadleaf weeds but is weak on cruciferous weeds such as wild mustard. Isoxaflutole also controls a number of broadleaf weeds but does not control wild buckwheat. Both sulfentrazone and isoxaflutole are soil-applied herbicides with potential to carry-over and injure rotational crops. Preliminary results from field trials indicate that combined low rates of sulfentrazone and isoxaflutole can result in excellent broad spectrum weed control in chickpea. Carfentrazone-ethyl, a contact non-residual PPO inhibitor has been shown to be an effective pre-seed burndown partner for glyphosate. This would allow for the control of volunteer Roundup-ready canola prior to the seeding of broadleaf crops