7 research outputs found
Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives
A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have been synthesized. They have been characterized by elemental analysis, IR, 1H and 13C NMR and mass spectral techniques. All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial activity. Among these (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone is more active. Moreover, the compound 3d shows promising antioxidant activity activity. The compounds have been further evaluated for their potential for DNA cleavage and two compounds completely cleaved DNA. Two of the compounds have been evaluated for their anti-proliferative activity against breast cancer cell lines. The IC50 value of the compound (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone against the cell line MCF-7 is found to be 10 µg/mL. Four compounds have been docked towards 5077 receptor protein. Molecular docking shows very good interaction with protein. In this (4-amino-2-(4-methoxyphenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone has the highest binding interaction with the protein.
Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives
1621-1628A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have
been synthesized. They have been characterized by elemental analysis, IR, 1H and 13C NMR and mass spectral techniques.
All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial
activity. Among these (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone is more
active. Moreover, the compound 3d shows promising antioxidant activity activity. The compounds have been further
evaluated for their potential for DNA cleavage and two compounds completely cleaved DNA. Two of the compounds have
been evaluated for their anti-proliferative activity against breast cancer cell lines. The IC50 value of the compound (4-amino2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
against the cell line MCF-7 is found to be
10 µg/mL. Four compounds have been docked towards 5077 receptor protein. Molecular docking shows very good
interaction with protein. In this (4-amino-2-(4-methoxyphenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
has the highest binding interaction with the protein
Neighbourhoods Alive!: Community Outcomes Final Report
report: 181 pp.; ill., digital file.The following evaluation of the Neighbourhoods Alive! strategy was undertaken in 2005. Neighbourhood outcomes—or present conditions in Neighbourhoods Alive!
neighbourhoods as expressed in both quantitative and qualitative terms—are discussed
where possible in relation to baseline data spanning 2001-2004, as well as a process
evaluation of the community-led model (CLM) as represented by the partnership between
the Neighbourhood Renewal Corporations (NRCs) and Neighbourhoods Alive! with the
NRCs being the instrument for bringing the community together and Neighbourhoods Alive! providing the
tools to support a community-led approach to neighbourhood revitalization in Winnipeg,
Brandon and Thompson. Conclusions are drawn as to the strengths and weaknesses of the
model and recommendations are provided. Guidelines for the replication of the
evaluation are contained within Appendix 3.Neighbourhoods Alive