1621-1628A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have
been synthesized. They have been characterized by elemental analysis, IR, 1H and 13C NMR and mass spectral techniques.
All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial
activity. Among these (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone is more
active. Moreover, the compound 3d shows promising antioxidant activity activity. The compounds have been further
evaluated for their potential for DNA cleavage and two compounds completely cleaved DNA. Two of the compounds have
been evaluated for their anti-proliferative activity against breast cancer cell lines. The IC50 value of the compound (4-amino2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
against the cell line MCF-7 is found to be
10 µg/mL. Four compounds have been docked towards 5077 receptor protein. Molecular docking shows very good
interaction with protein. In this (4-amino-2-(4-methoxyphenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
has the highest binding interaction with the protein
