A Brief History of Archaeology at Ole Miss (Mississippi Archaeological Association Newsletter, 58.2, August 2022)

A summary of the archaeologists holding faculty positions in the Department of Sociology and Anthropology at the University of Mississippi from 1949 (Fall) through 2022 (Spring) based on the University\u27s annual catalogue. Also includes a selected bibliography of faculty publications, a list of M.A. theses in Anthropology from 1963-2022, and archival photographs

Conformational Heterogeneity of a Leucine Enkephalin Analog in Aqueous Solution and SDS Micelles: Comparison of Time- Resolved FRET and Molecular Dynamics Simulations

We have undertaken time-resolved Förster resonance energy transfer (FRET) and molecular dynamics simulations to analyze conformations and conformational heterogeneity of an analog of leucine enkephalin in solution and in the presence of SDS micelles. Enkephalins are opioid pentapeptides that interact with opioid receptors in the central nervous system. We used timecorrelated single-photon counting to detect energy transfer between the N-terminal tyrosine and a tryptophan residue substituted for phenylalanine at the 4 position. FRET from Tyr to Trp was measured over a temperature range from 5°C to 55°C in aqueous solution. By taking into account Tyr rotamer interconversion rates measured previously, we determined average distances between Tyr and Trp for the two populated rotameric conformations of Tyr. Molecular dynamics simulations (100 ns) support this analysis and indicate extensive conformational heterogeneity. The simulations also predict that the FRET orientational factor is correlated with the Tyr-Trp separation. Failure to account for the correlation between orientation and distance results in errors that appear to be largely offset in YGGWL by a weighting bias inherent in the R−6 dependence of the energy-transfer rate. The Tyr lifetimes decrease upon titration of the peptides with SDS, indicating formation of compact conformations of the peptide in the micelle environment. This result is consistent with the conjecture that the lipid environment may induce formation of bioactive conformations of the peptide

Reducing Crop Production Cost

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Most Asked Agronomic Questions

Exact date of bulletin unknown.PDF pages: 4

Myeloid suppressor cell depletion augments antitumor activity in lung cancer.

BackgroundMyeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer.Principal findingsIndividual antibody mediated depletion of MDSC (anti-Gr1 or anti-Ly6G) enhanced the antitumor activity against lung cancer. In comparison to controls, MDSC depletion enhanced the APC activity and increased the frequency and activity of the NK and T cell effectors in the tumor. Compared to controls, the anti-Gr1 or anti-Ly6G treatment led to increased: (i) CD8 T cells, (ii) NK cells, (iii) CD8 T or NK intracytoplasmic expression of IFNγ, perforin and granzyme (iv) CD3 T cells expressing the activation marker CD107a and CXCR3, (v) reduced CD8 T cell IL-10 production in the tumors (vi) reduced tumor angiogenic (VEGF, CXCL2, CXCL5, and Angiopoietin1&2) but enhanced anti-angiogenic (CXCL9 and CXCL10) expression and (vii) reduced tumor staining of endothelial marker Meca 32. Immunocytochemistry of tumor sections showed reduced Gr1 expressing cells with increased CD3 T cell infiltrates in the anti-Gr1 or anti-Ly6G groups. MDSC depletion led to a marked inhibition in tumor growth, enhanced tumor cell apoptosis and reduced migration of the tumors from the primary site to the lung compared to controls. Therapeutic vaccination responses were enhanced in vivo following MDSC depletion with 50% of treated mice completely eradicating established tumors. Treated mice that rejected their primary tumors acquired immunological memory against a secondary tumor challenge. The remaining 50% of mice in this group had 20 fold reductions in tumor burden compared to controls.SignificanceOur data demonstrate that targeting MDSC can improve antitumor immune responses suggesting a broad applicability of combined immune based approaches against cancer. This multifaceted approach may prove useful against tumors where MDSC play a role in tumor immune evasion

Indigenous research sovereignties: Sparking the deeper conversations we need

This article is part of the Environment and Planning F: Philosophy, Theory, Models, Methods and Practice special issue on ‘Indigenous Research Sovereignty’, edited by Jay T. Johnson, Joseph P. Brewer II., Melissa K. Nelson, Mark H. Palmer, and Renee Pualani Louis.This article seeks to spark a conversation and further debate through the 15 papers and 3 commentaries comprising this special issue entitled “Indigenous Research Sovereignty.” By inviting the authors to publish in this special edition and address Indigenous Research Sovereignty from a variety of viewpoints, we have brought together a collection that inspires, transforms, and expands on the ways in which Indigenous and non-Indigenous researchers are engaging with Indigenous communities to address the research agendas of communities across the globe. Through our work together over the past 8 years, the editorial team have identified eight themes within this broad concept of Indigenous Research Sovereignty. This article provides an introduction to those eight themes in the broadest strokes, while the papers and commentaries explore and refine them with significant depth. We seek to spark a conversation, we do not intend to provide answers to any of the dilemma facing Indigenous communities as they engage, or choose not to engage, in research. Our primary goal is to express an all-encompassing concern for the protection of Indigenous Communities’ inherent rights and knowledges.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The guest editors acknowledge financial support for the FIRST Network by the United States National Science Foundation through grant number 1417767

Beef Cattle Feeding in a Bedded Hoop Barn: Three Year Summary

A three-year study evaluating the performance of yearling steers fed and confined in a bedded hoop barn was completed. A 50 × 120 foot hoop barn was constructed at the ISU Armstrong Research Farm in the late fall of 2004. The comparison feedlot is an outside lot with shelter that includes a drive-through feed alley. Two groups of yearling steers were fed each year. The summer/fall groups were put on test in August and marketed in November. The winter/spring groups were put on test in December and marketed in April/May. Overall the cattle fed in the bedded confinement hoop barn performed similarly with similar carcass data to cattle fed in a semi-confined feedlot. The cattle from the hoop barn had numerically lower mud scores than the feedlot cattle, i.e., had less mud at the end of the test. As expected the deep-bedded hoop system used more bedding than the semi-confinement lots. The bedded hoop barn required about 5 to 6 lb of cornstalk bedding per head per day that the steers were on feed