Selenium Responsive Dermatosis in Cattle

A yearling Maine-Anjou heifer was admitted to the Iowa State University Veterinary Teaching Hospital for diagnosis and treatment of a clinical problem characterized by weight loss, extensive hair loss and multiple 2-5 cm skin lesions around the face, poll, ears, neck, back and rump regions. Less extensive lesions of similar appearance were also found on the legs and underline. Grossly, many of the lesions were ringworm-like in appearance with prominent, whitish, asbestos-like accumulations of scaley material on the surface

Epidemiology of Acromegaly: Review of population studies

Acromegaly is a rare condition necessitating large population studies for the generation of reliable epidemiological data. In this review, we systematically analysed the epidemiological profile of this condition based on recently published population studies from various geographical areas. The total prevalence ranges between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates range between 0.2 and 1.1 cases/100,000 people. The median age at diagnosis is in the fifth decade of life with a median diagnostic delay of 4.5–5 years. Acral enlargement and coarse facial features are the most commonly described clinical manifestations. At the time of detection, most of the tumors are macroadenomas possibly relating to diagnostic delays and posing challenges in the surgical management. Increased awareness of acromegaly amongst the medical community is of major importance aiming to reduce the adverse sequelae of late diagnosis and treatment, improve patient outcomes and, hopefully, reduce the burden on the health care system

Business collaboration for improved value net performance

Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1999.Includes bibliographical references (leaves 58-60).by John S. Wass.M.Eng

Metabolic syndrome in polycystic ovary syndrome

Zespół metaboliczny (MS, metabolic syndrome) i zespół policystycznych jajników (PCOS, polycystic ovary syndrome) są często rozpoznawanymi zaburzeniami u kobiet. Częstość występowania zespołu metabolicznego u kobiet z PCOS zależy od zastosowanych kryteriów diagnostycznych. W prezentowanej pracy autorzy rozważają tezę, że przyczyną obu zaburzeń może być insulinooporność, będąca następstwem otyłości brzusznej. Ponadto dokonują przeglądu literatury dotyczącej występowania MS u kobiet z PCOS oraz omawiają wpływ wyboru określonych kryteriów diagnostycznych MS i PCOS na oszacowanie czêstoœci ich występowania.Both metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) are common among women. The exact prevalence of MS in women with PCOS is dependent upon the diagnostic criteria used for each. However, the frequent co-occurrence of both MS and PCOS in women is suggestive of a common aetiology. In this short review article we argue that insulin resistance, as a consequence of abdominal obesity, may represent such a common aetiology. We also review the literature on the prevalence of MS in women with PCOS and consider the impact that the particular criteria used to diagnose both MS and PCOS may have had on these estimates of prevalence

Chemotactic factor-induced adherence of tumor cells

Two peptides which have previously been shown to induce chemotactic motility in a number of tumor cells were tested for their ability to alter the adhesiveness of Walker Carcinosarcoma cells (A chemotactically-responsive rat tumor) and normal rat fibrobalsts (which have previously been shown to be chemotactically nonresponsive). Adherence of the tumor cells to nylon fibers was increased in a dose-dependent manner by the two active peptides. Adherence of the fibroblasts was not increased. Nonchemotactic peptide analogues of the two active peptides did not alter the adherence of either cell type. The increased adhesiveness to foreign surfaces may contribute to the chemotactic response.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24389/1/0000659.pd

Responses of normal and malignant cells to collagen, collagen-derived peptides and the C5-related tumor cell chemotactic peptide

Two variant subpopulations of murine fibrosarcoma cells that differ significantly in their malignant potential and normal mouse fibroblasts were compared with regard to ability to respond chemotactically to collagen, collagen-derived peptides and the C5-derived tumor cell chemotactic peptide. Two distinct patterns of responsiveness were observed. The normal fibroblasts and non-metastasizing fibrosarcoma cells responded to the collagen products but not the C5 peptide. The metastasizing fibrosarcoma cells responded to the C5 peptide but not to the collagen products. These findings emphasize the similarities between the normal fibroblasts and the non-metastasizing fibrosarcoma cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24181/1/0000440.pd