Beach surveys of South Carlsbad State Beach onshore of Carlsbad artificial reef

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Election Day — Documentary

Election Day is a three-channel documentary chronicling the places, personalities, and tone of Little Rock, Arkansas, during its titular midterm Election Day in November 2018. Throughout the course of the day, the film branches across the city, capturing mini-narratives, bits of conversation, and tableau of civic activity in the public sphere. It is less concerned with the quantitative facts of the day as it is with conveying the transitory social expressions and moods of a modern, southern city on a uniquely American day. This project represents my continued documentary interest in creating inclusive, contemporary local portraits and counter-historical chronicles of Arkansas’s capitol city in light of the current political moment

Method of glass melter electrode length measurement using time domain reflectometry (TDR)

The present invention overcomes the drawbacks inherent in the prior art and solves the problems inherent in conventional Joule-heated vitrification melters, where the melter preferably comprises a vessel having a refractory liner and an opening for receiving material which is converted into molten vitreous material in the vessel. The vessel has an outlet port for removing molten vitreous material from the vessel. A plurality of electrodes is disposed in the vessel and electrical energy is passed between electrode pairs through feed material and molten vitreous material in the vessel. Typically, the electrodes erode and wear in time, and this invention seeks to monitor and evaluate the length and condition of the electrodes. The present invention uses time domain reflectometry (TDR) methods to accurately measure the length of an electrode that is subject to wear and electrolytic decomposition due to the extreme conditions in which the electrode is required to operate. Specifically, TDR would be used to measure the length and effects of erosion of molybdenum electrodes used in Joule-heated vitrification melter. Of course, the inventive concept should not be limited to this preferred environment

Role of Collaborative Academic Partnerships in Surgical Training, Education, and Provision

The global disparities in both surgical disease burden and access to delivery of surgical care are gaining prominence in the medical literature and media. Concurrently, there is an unprecedented groundswell in idealism and interest in global health among North American medical students and trainees in anesthesia and surgical disciplines. Many academic medical centers (AMCs) are seeking to respond by creating partnerships with teaching hospitals overseas. In this article we describe six such partnerships, as follows: (1) University of California San Francisco (UCSF) with the Bellagio Essential Surgery Group; (2) USCF with Makerere University, Uganda; (3) Vanderbilt with Baptist Medical Center, Ogbomoso, Nigeria; (4) Vanderbilt with Kijabe Hospital, Kenya; (5) University of Toronto, Hospital for Sick Children with the Ministry of Health in Botswana; and (6) Harvard (Brigham and Women’s Hospital and Children’s Hospital Boston) with Partners in Health in Haiti and Rwanda. Reflection on these experiences offers valuable lessons, and we make recommendations of critical components leading to success. These include the importance of relationships, emphasis on mutual learning, the need for “champions,” affirming that local training needs to supersede expatriate training needs, the value of collaboration in research, adapting the mission to locally expressed needs, the need for a multidisciplinary approach, and the need to measure outcomes. We conclude that this is an era of cautious optimism and that AMCs have a critical opportunity to both shape future leaders in global surgery and address the current global disparities

Ares I-X Range Safety Analyses Overview

Ares I-X was the first test flight of NASA's Constellation Program's Ares I Crew Launch Vehicle designed to provide manned access to low Earth orbit. As a one-time test flight, the Air Force's 45th Space Wing required a series of Range Safety analysis data products to be developed for the specified launch date and mission trajectory prior to granting flight approval on the Eastern Range. The range safety data package is required to ensure that the public, launch area, and launch complex personnel and resources are provided with an acceptable level of safety and that all aspects of prelaunch and launch operations adhere to applicable public laws. The analysis data products, defined in the Air Force Space Command Manual 91-710, Volume 2, consisted of a nominal trajectory, three sigma trajectory envelopes, stage impact footprints, acoustic intensity contours, trajectory turn angles resulting from potential vehicle malfunctions (including flight software failures), characterization of potential debris, and debris impact footprints. These data products were developed under the auspices of the Constellation's Program Launch Constellation Range Safety Panel and its Range Safety Trajectory Working Group with the intent of beginning the framework for the operational vehicle data products and providing programmatic review and oversight. A multi-center NASA team in conjunction with the 45th Space Wing, collaborated within the Trajectory Working Group forum to define the data product development processes, performed the analyses necessary to generate the data products, and performed independent verification and validation of the data products. This paper outlines the Range Safety data requirements and provides an overview of the processes established to develop both the data products and the individual analyses used to develop the data products, and it summarizes the results of the analyses required for the Ares I-X launch

Bosutinib Reduces the Efficacy of Dasatinib in Triple-negative Breast Cancer Cell Lines

Background—Triple-negative breast cancer (TNBC) is an aggressive sub-type of breast cancer. Dasatinib and bosutinib are FDA-approved Src/Abl kinase inhibitor drugs. Dasatinib potently inhibits the proliferation of many TNBC cell lines. Material and Methods—The cell viability/proliferation for a panel of 4 TNBC cell lines was measured by detection of cellular ATP levels and cell numbers directly determined by automated cell counting. Results—Bosutinib (≤1 μM) had little to no inhibitory activity on cell viability/proliferation, while dasatinib-alone generated potent IC50 values of <100 nM. Combination treatment of cells with both dasatinib and bosutinib resulted in reduced efficacy of dasatinib in all four cell lines, with two of them displaying a dramatic loss of efficacy. Direct cell counting confirmed that bosutinib enhanced cell proliferation in the presence of dasatinib. Conclusion—Bosutinib potently reduced the in vitro anti-proliferative efficacy of dasatinib in TNBC cell lines. We, thereby, report on a novel drug-induced loss in dasatinib sensitivity