Ecto- and Endoparasites of the Texas Deermouse, Peromyscus attwateri and Eastern Woodrat, Neotoma floridana (Rodentia: Cricetidae) from Polk County, Arkansas

In Arkansas, the Texas deermouse (Peromyscus attwateri) occurs in the western part of the state where it is restricted to the uplands of the Interior Highlands. The eastern woodrat (Neotoma floridana) is found statewide but is less common in the Gulf Coastal Plain. Very little is known about the parasites of either rodent in Arkansas, especially helminths from P. attwateri at any locality within its range. Found in/on P. attwateri were a coccidian (Eimeria langbarteli), a tapeworm (Catenotaenia peromysci), a nematode (Syphacia peromysci), 2 ticks (Dermacenter variabilis and Ixodes scapularis), and 2 mites (Androlaelaps fahrenholzi and Leptotrombidium peromysci). Eastern woodrats harbored 3 nematodes (Eucoelus sp., Longistriata neotoma, and Trichurus neotomae), a larval bot fly (Cuterebra americana), and a flea (Orchopeas pennsylvanicus). We document 6 new host and 5 new distributional records for these parasites

Eimeria lancasterensis (Apicomplexa: Eimeriidae), Three Nematodes (Heligmosomoidea: Boehmiellidae, Heligmonellidae), and a Flea (Siphonaptera: Ceratophyllidae) from the Eastern Fox Squirrel, Sciurus niger (Rodentia: Sciuridae) in Arkansas

In Arkansas, the eastern fox squirrel (Sciurus niger) is a common inhabitant of the state. Although information is available on ectoparasites of this host in Arkansas, little is known about the endoparasites of this squirrel. A single specimen from Montgomery County was examined and found to harbor the following: a coccidian (Eimeria lancasterensis), three nematodes, Boehmiella wilsoni, Citellinema bifurcatum, and Sciurodendrium hassalli, and a flea, Orchopeas howardi. We document these nematodes from an Arkansas S. niger for the first time, and add mensural and molecular information on E. lancasterensis from this host

Uptake of hepatitis C specialist services and treatment following diagnosis by dried blood spot in Scotland

Background: Dried blood spot (DBS) testing for hepatitis C (HCV) was introduced to Scotland in 2009. This minimally invasive specimen provides an alternative to venipuncture and can overcome barriers to testing in people who inject drugs (PWID). Objectives: The objective of this study was to determine rates and predictors of: exposure to HCV, attendance at specialist clinics and anti-viral treatment initiation among the DBS tested population in Scotland. Study design: DBS testing records were deterministically linked to the Scottish HCV Clinical database prior to logistic regression analysis. Results: In the first two years of usage in Scotland, 1322 individuals were tested by DBS of which 476 were found to have an active HCV infection. Linkage analysis showed that 32% had attended a specialist clinic within 12 months of their specimen collection date and 18% had begun anti-viral therapy within 18 months of their specimen collection date. A significantly reduced likelihood of attendance at a specialist clinic was evident amongst younger individuals (<35 years), those of unknown ethnic origin and those not reporting injecting drug use as a risk factor. Conclusion: We conclude that DBS testing in non-clinical settings has the potential to increase diagnosis and, with sufficient support, treatment of HCV infection among PWID

Parasites (Trematoda, Nematoda, Phthiraptera) of Two Arkansas Raptors (Accipitriformes: Accipitridae; Strigiformes: Strigidae)

Very little is known about the helminth parasites of hawks and owls of Arkansas. We had the opportunity to salvage 2 road-killed raptors, a red-shouldered hawk (Buteo lineatus) and a great horned owl (Bubo virginianus) from the state and examine them for ecto- and endoparasites. Found were chewing lice (Degeeriella fulva) and a nematode (Porrocaecum angusticolle) on/in B. lineatus, and 3 digenean trematodes (Echinoparyphium sp., Strigea elegans, Neodiplostomum americanum), and nematode eggs (Capillaria sp.) in B. virginianus. We document 6 new distributional records for these parasites

The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: A 5-year prospective registry

BACKGROUND: To compare illness characteristics, treatment history, response and durability, and suicidality scores over a 5-year period in patients with treatment-resistant bipolar depression participating in a prospective, multicenter, open-label registry and receiving Vagus Nerve Stimulation Therapy (VNS Therapy) plus treatment-as-usual (VNS + TAU) or TAU alone. METHODS: Response was defined as ≥ 50% decrease from baseline Montgomery-Åsberg Depression Rating Scale (MADRS) total score at 3, 6, 9, or 12 months post-baseline. Response was retained while MADRS score remained ≥ 40% lower than baseline. Time-to-events was estimated using Kaplan-Meier (KM) analysis and compared using log-rank test. Suicidality was assessed using the MADRS Item 10 score. RESULTS: At baseline (entry into registry), the VNS + TAU group (N = 97) had more episodes of depression, psychiatric hospitalizations, lifetime suicide attempts and higher suicidality score, more severe symptoms (based on MADRS and other scales), and higher rate of prior electroconvulsive therapy than TAU group (N = 59). Lifetime use of medications was similar between the groups (a mean of 9) and was consistent with the severe treatment-resistant nature of their depression. Over 5 years, 63% (61/97) in VNS + TAU had an initial response compared with 39% (23/59) in TAU. The time-to-initial response was significantly quicker for VNS + TAU than for TAU (p \u3c 0.03). Among responders in the first year after implant, the KM estimate of the median time-to-relapse from initial response was 15.2 vs 7.6 months for VNS + TAU compared with TAU (difference was not statistically significant). The mean reduction in suicidality score across the study visits was significantly greater in the VNS + TAU than in the TAU group (p \u3c 0.001). CONCLUSIONS: The patients who received VNS + TAU included in this analysis had severe bipolar depression that had proved extremely difficult to treat. The TAU comparator group were similar though had slightly less severe illnesses on some measures and had less history of suicide attempts. Treatment with VNS + TAU was associated with a higher likelihood of attaining a response compared to TAU alone. VNS + TAU was also associated with a significantly greater mean reduction in suicidality. LIMITATIONS: In this registry study, participants were not randomized to the study treatment group, VNS Therapy stimulation parameters were not controlled, and there was a high attrition rate over 5 years. Trial registration ClinicalTrials.gov NCT00320372. Registered 3 May 2006, https://clinicaltrials.gov/ct2/show/NCT00320372 (retrospectively registered)

Computational environment for modeling and enhancing community resilience: Introducing the center for risk-based community resilience planning

The resilience of a community is defined as its ability to prepare for, withstand, recover from and adapt to the effects of natural or human-caused disasters, and depends on the performance of the built environment and on supporting social, economic and public institutions that are essential for immediate response and long-term recovery and adaptation. The performance of the built environment generally is governed by codes, standards, and regulations, which are applicable to individual facilities and residences, are based on different performance criteria, and do not account for the interdependence of buildings, transportation, utilities and other infrastructure sectors. The National Institute of Standards and Technology recently awarded a new Center of Excellence (NIST-CoE) for Risk-Based Community Resilience Planning, which is headquartered at Colorado State University and involves nine additional universities. Research in this Center is focusing on three major research thrusts: (1) developing the NIST-Community Resilience Modeling Environment known as NIST-CORE, thereby enabling alternative strategies to enhance community resilience to be measured quantitatively; (2) developing a standardized data ontology, robust data architecture and data management tools in support of NIST-CORE; and (3) performing a comprehensive set of hindcasts on disasters to validate the data architecture and NIST-CORE

On the biological and genetic diversity in Neospora caninum

Published: 22 March 2010Neospora caninum is a parasite regarded a major cause of foetal loss in cattle. A key requirement to an understanding of the epidemiology and pathogenicity of N. caninum is knowledge of the biological characteristics of the species and the genetic diversity within it. Due to the broad intermediate host range of the species, worldwide geographical distribution and its capacity for sexual reproduction, significant biological and genetic differences might be expected to exist. N. caninum has now been isolated from a variety of different host species including dogs and cattle. Although isolates of this parasite show only minor differences in ultrastructure, considerable differences have been reported in pathogenicity using mainly mouse models. At the DNA level, marked levels of polymorphism between isolates were detected in mini- and microsatellites found in the genome of N. caninum. Knowledge of what drives the biological differences that have been observed between the various isolates at the molecular level is crucial in aiding our understanding of the epidemiology of this parasite and, in turn, the development of efficacious strategies, such as live vaccines, for controlling its impact. The purpose of this review is to document and discuss for the first time, the nature of the diversity found within the species Neospora caninum.Sarwat E. Al-Qassab, Michael P. Reichel and John T. Elli

Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism

Purpose.Albinism is associated with disrupted foveal development, though intersubject variability is becoming appreciated. We sought to quantify this variability, and examine the relationship between foveal cone specialization and pit morphology in patients with a clinical diagnosis of albinism. Methods. We recruited 32 subjects with a clinical diagnosis of albinism. DNA was obtained from 25 subjects, and known albinism genes were analyzed for mutations. Relative inner and outer segment (IS and OS) lengthening (fovea-to-perifovea ratio) was determined from manually segmented spectral domain-optical coherence tomography (SD-OCT) B-scans. Foveal pit morphology was quantified for eight subjects from macular SD-OCT volumes. Ten subjects underwent imaging with adaptive optics scanning light ophthalmoscopy (AOSLO), and cone density was measured. Results. We found mutations in 22 of 25 subjects, including five novel mutations. All subjects lacked complete excavation of inner retinal layers at the fovea, though four subjects had foveal pits with normal diameter and/or volume. Peak cone density and OS lengthening were variable and overlapped with that observed in normal controls. A fifth hyper-reflective band was observed in the outer retina on SD-OCT in the majority of the subjects with albinism. Conclusions. Foveal cone specialization and pit morphology vary greatly in albinism. Normal cone packing was observed in the absence of a foveal pit, suggesting a pit is not required for packing to occur. The degree to which retinal anatomy correlates with genotype or visual function remains unclear, and future examination of larger patient groups will provide important insight on this issue

Femto-Photography of Protons to Nuclei with Deeply Virtual Compton Scattering

Developments in deeply virtual Compton scattering allow the direct measurements of scattering amplitudes for exchange of a highly virtual photon with fine spatial resolution. Real-space images of the target can be obtained from this information. Spatial resolution is determined by the momentum transfer rather than the wavelength of the detected photon. Quantum photographs of the proton, nuclei, and other elementary particles with resolution on the scale of a fraction of a femtometer is feasible with existing experimental technology.Comment: To be published in Physical Review D. Replaces previous version with minor changes in presentatio