Ergänzungen zur iberischen Pseudoscorpioniden-Fauna

Die systematischen Aufsammlungen, die Prof. Dr. H. Franz in den letzten Jahren in weiten Teilen der iberischen Halbinsel durchführte, schliessen weitgehend die Lücken, die bisher noch zwischen den explorierten Gebieten klafften. Sie ergänzen und berichtigen daher unsere bisherigen, von mir letztmals 1955 (Eos, XXXI, pp. 87-122) zusammengefassten Kenntnisse in taxonomischer und faunistischer Hinsicht und runden das Faunenbild auch tiergeographisch zu erfreulicher Vollständigkeit ab. Die Ausbeuten enthielten wiederum 8 neue Arten beziehungsweise Unterarten. Drei weitere Arten waren für Spanien neu. In den cantabrischen Gebirgen tritt nunmehr die Gattung Microcreagris als charakteristisches Faunenelement noch stärker hervor.— Im folgenden werden die seither gemachten Funde angeführt.Peer reviewe

Additional file 2: of Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

GO term enrichment for expression-based clusters in rapamycin-treated yeast. (XLSX 161 kb

Additional file 1: Supplementary Text and Figures. of Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

Supplementary text describes (a) the robustness of the results to the growth rate cutoff for yeast strains, (b) an analysis combining differential expression with protein interaction degree, and (c) the characterization of the protein interactors of driver TFs. Figures present results for (i) network integration for rapamycin data with alternative growth cutoff, (ii) PANDA analysis of rapamycin expression data, (iii) rapamycin network integration using only yeast two-hybrid data, (iv) results of combining differential expression with PPI degree, (v) ROC curves for network integration in multiple yeast conditions, and (vi) the rank characteristics and local PPI neighborhoods of driver TFs for menadione, DTT and diamide. (PDF 1304 kb

Additional file 5: of Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

Lists of enriched GO terms for the direct protein interactors of subsets of driver TFs that are ranked higher using the combined network score than either individual network. Lists correspond to the following conditions: rapamycin, diamide and menadione in yeast, and viral oncogene perturbation in humans. (XLSX 77 kb

Additional file 4: of Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

Top transcription factors, as ranked either by 1) differential expression by transforming viral oncogenes, 2) degree in the GMIT network or 3) degree in the PANDA network. (XLSX 41 kb

The majority of COPD Network GWAS SNPs are annotated for functional impact.

<p>Of the 30 SNPs that are eQTLs in the LGRC network and also associated with COPD (FDR < 0.05), 15 are likely to affect transcription factor (TF) binding and linked to the expression of a target gene (a score of 1b, d, or f), 2 have evidence of TF binding or a DNase peak (a score of 5), and 11 are located in a motif hit (a score of 6) according to RegulomeDB [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005033#pcbi.1005033.ref037" target="_blank">37</a>].</p

The median core score for COPD Network GWAS SNPs is higher than for non-significant SNPs.

<p>The median core score for the 30 FDR-significant COPD GWAS SNPs (FDR < 0.05, left) is 20.3 times higher than the median core score for the non-significant SNPs (FDR ≥ 0.05, right).</p

NHGRI-GWAS SNPs have higher core scores than non-GWAS SNPs based on Kolmogorov-Smirnov test statistics.

<p>Histogram of Kolmogorov-Smirnov test statistics comparing the distribution of <i>Q</i>_<i>ih</i> scores for sets of randomly relabeled NHGRI-GWAS/non-GWAS SNPs. The KS test statistic for the true labeling is in red. The permutation p-value associated with the KS test is <i>P</i> < 10⁻⁵ given 10⁵ permutations.</p

eQTLs show strong community structure.

<p><b>(a)</b> Plot of the communities within the bipartite eQTL network. The nodes (genes and SNPs) in each community form a ring, with the link density within each ring visibly darker than links between communities. <b>(b)</b> Links within communities (colored points) are shown along the diagonal, with links that go between communities in black. Community IDs are plotted along the <i>x</i>-axis.</p

NHGRI-GWAS SNPs have higher core scores than non-GWAS SNPs based on Wilcoxon test statistics.

<p>Histogram of Wilcoxon test statistics comparing the distribution of <i>Q</i>_<i>ih</i> scores for sets of randomly relabeled NHGRI-GWAS/non-GWAS SNPs. The Wilcoxon test statistic for the true labeling is in red. The permutation p-value associated with the Wilcoxon test is <i>P</i> < 10⁻⁵ given 10⁵ permutations.</p