Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia

Key Points First report demonstrating in vivo elimination of multiple LIC populations from childhood ALL cases using animal models. In vivo models of leukemia are essential for drug evaluation studies.</jats:p

A Detailed Analysis of a Cygnus Loop Shock-Cloud Interaction

The XA region of the Cygnus Loop is a complex zone of radiative and nonradiative shocks interacting with interstellar clouds. We combine five far ultraviolet spectral observations from the Hopkins Ultraviolet Telescope (HUT), a grid of 24 IUE spectra and a high-resolution longslit Halpha spectrum to study the spatial emission line variations across the region. These spectral data are placed in context using ground-based, optical emission line images of the region and a far-UV image obtained by the Ultraviolet Imaging Telescope (UIT). The presence of high-ionization ions (OVI, NV, CIV) indicates a shock velocity near 170 km/s while other diagnostics indicate v_shock=140 km/s. It is likely that a large range of shock velocities may exist at a spatial scale smaller than we are able to resolve. By comparing CIV 1550, CIII 977 and CIII] 1909, we explore resonance scattering across the region. We find that a significant column depth is present at all positions, including those not near bright optical/UV filaments. Analysis of the OVI doublet ratio suggests an average optical depth of about unity in that ion while flux measurements of [SiVIII] 1443 suggest a hot component in the region at just below 10^6K. Given the brightness of the OVI emission and the age of the interaction, we rule out the mixing layer interpretation of the UV emission. Furthermore, we formulate a picture of the XA region as the encounter of the blast wave with a finger of dense gas protruding inward from the pre-SN cavity.Comment: 21 pages, 9 figures, accepted by the Astronomical Journal, July 2001 Full resolution figures available at http://fuse.pha.jhu.edu/~danforth/xa