Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45695/1/11336_2005_Article_BF02289164.pd

Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation

, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell acute lymphoblastic leukemia/lymphoma (T-ALL), and maintain T-ALL cell growth and survival., a direct Notch target that has an important role in Notch-associated T-ALL.We conclude that the leukemogenic potentials of Notch receptors vary, and that this functional difference stems in part from divergence among the highly conserved ankyrin repeats, which influence the transactivation of specific target genes involved in leukemogenesis

Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45707/1/11336_2005_Article_BF02288937.pd