Barack Obama's America

The election of Barack Obama to the presidency marked a conclusive end to the Reagan era, writes John Kenneth White in Barack Obama's America. Reagan symbolized a 1950s and 1960s America, largely white and suburban, with married couples and kids at home, who attended church more often than not. Obama's election marked a new era, the author writes. Whites will be a minority by 2042. Marriage is at an all-time low. Cohabitation has increased from a half-million couples in 1960 to more than 5 million in 2000 to even more this year. Gay marriages and civil unions are redefining what it means to be a family. And organized religions are suffering, even as Americans continue to think of themselves as a religious people. Obama's inauguration was a defining moment in the political destiny of this country, based largely on demographic shifts, as described in Barack Obama's America

American Political Parties

American Political Parties is a core textbook on political parties in the United States that places the US party system into a framework designed around the disagreements between Alexander Hamilton and Thomas Jefferson. White and Kerbel argue that the two-party system in the United States began with a common agreement on the key values of freedom, individual rights, and equality of opportunity but that Hamilton and Jefferson disagreed—often vehemently—over how to translate these ideals into an acceptable form of governance. This text develops a unique historical perspective of US party development using the disagreements between Alexander Hamilton and Thomas Jefferson as a framework for analysis. While Hamilton wanted to marry freedom to a strong, active federal government with an energetic president who would act on behalf of all citizens, Jefferson believed that freedom should be allied to local civic virtue, with governmental responsibilities placed primarily at the local level. Today, Hamiltonian nationalism finds its home in the Democratic Party, while Republicans have espoused Jeffersonian localism since 1964. Using this historical framework, American Political Parties examines a range of topics including marketing and social media, campaign finance, reforms in the presidential nominating process, political demography, and third parties. In this new edition (previously published as Party On!), the authors describe four possible futures in the wake of the 2020 election and why Americans believed it was “the most important” election in their lifetimes. The unique history of US political parties as set forth by the disagreements between Alexander Hamilton and Thomas Jefferson is at an inflection point. Republicans have become an insurgent party fully under the control of Donald Trump while Democrats have an opportunity to create a new majority coalition. This juncture poses unique challenges to our democracy and constitutional framework, and the book describes four possible outcomes, postulating where American political parties are headed in this decade. This book is published as part of the Sustainable History Monograph Pilot, with the generous support of the Andrew W. Mellon Foundation

Donald Trump and the Republican Party: The Making of a Faustian Bargain

Donald Trump’s presidency is likely to become what Stephen Skowronek once labeled as a “disjunctive presidency.” Trump’s election in 2016 and the issue positions he has taken mark the end of the Reagan Era. Just as Jimmy Carter’s one-term signaled the end of the New Deal era begun by Franklin D. Roosevelt, so, too, does Trump’s already troubled presidency signify the end of Reagan’s conservatism. Changing demographics have hastened the end of the Reagan era, and the next presidential contest is likely to be one that James David Barber called a “politics as conscience,” not a conflict election to which Trump was well-suited. Trump’s victory, along with the end of the Reagan era, also signals a moment of significant danger for the Republican Party, despite the present unified GOP control of the federal government and recent gains that the party has made at the state and local levels

CodeVA Elementary Coaches Academy : Impact of Computer Science Implementation in K-5

Abstract This study investigated the impact of CodeVA’s elementary coach’s academy (ECA) on computer science implementation in elementary schools across the state of Virginia. The research took a multimethod qualitative and quantitative approach through surveys, focus groups, interviews and observations of ECA coaches and participants, along with the analysis of historical data provided by CodeVA. The capstone research questions were: “What is the impact of the elementary coaches academy?” and “What impacts the effectiveness of CodeVA’s elementary coaches academy?” In general, the data collected suggested that CodeVA has been effective in reaching its intended audience and meeting the needs of cohort participants, but there is still room for improvement. The review of the data resulted in five overarching anchors being identified that produced the following recommendations: “ use evidenced based coaching models to increase impact”; “utilize adult learning principles to create specific professional development”; “create a more structured professional learning community for ECA”; “improve advanced communication of ECA professional development opportunities” and “create a cache of resources to improve outside access to information for facilitators and coaches of the ECA” Keywords: CodeVA, computer science, elementary coaches academ

The Role of Signaling When Promoting Diversity and Inclusion at the Firm Level: A Financial Advisory Professional Case Study

Based on signaling theory and visual perception theory, this study evaluated how financial advisory firms depict diversity through online platforms. Signals sent by firms may impact outsiders’ understanding of race and gender inclusion at the firm level, which may explain why some struggle to recruit and retain a diverse workforce. To evaluate, 1,379 advisor biographies on 73 firm websites were analyzed. In this study, 29% of all client-facing advisors with known gender were women; only 0.5% of those with known race were Black. This is much lower than what other studies, based on different industrial codes, have reported. The fact that White males featured predominantly in depictions of employees on firm websites may influence who applies for positions in financial advisory firms. This signaling pattern may also indicate hiring preferences among firm owners and managers. Results have implications for firms that wish to recruit and retain a diverse workforce

Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: study design and conduct

Background In 2010, after regulatory review of rosiglitazone licensing, the US Food and Drug Administration (FDA) requested a reevaluation of cardiovascular end points in the RECORD trial.<p></p> Methods Automated screening of the original clinical trial database and manual case report form review were performed to identify all potential cardiovascular and noncardiovascular deaths, and nonfatal myocardial infarction (MI) and stroke events. Search techniques were used to find participants lost to follow-up, and sites were queried for additional source documents. Suspected events underwent blinded adjudication using both original RECORD end point definitions and new FDA end point definitions, before analysis by the Duke Clinical Research Institute.<p></p> Results The reevaluation effort included an additional 328 person-years of follow-up. Automated screening identified 396 suspected deaths, 2,052 suspected MIs, and 468 suspected strokes. Manual review of documents by Duke Clinical Research Institute clinical events classification (CEC) coordinators identified an additional 31 suspected deaths, 49 suspected MIs, and 28 suspected strokes. There were 127 CEC queries issued requesting additional information on suspected deaths; 43 were closed with no site response, 61 were closed with a response that no additional data were available, and additional data were received for 23. Seventy CEC queries were issued requesting additional information for suspected MI and stroke events; 31 were closed with no site response, 20 were closed with a response that no additional data were available, and 19 resulted in additional data.<p></p> Conclusions Comprehensive procedures were used for rigorous event reascertainment and readjudication in a previously completed open-label, global clinical trial. These procedures used in this unique situation were consistent with other common approaches in the field, were enhanced to address the FDA concerns about the original RECORD trial results, and could be considered by clinical trialists designing event readjudication protocols for drug development programs that have been completed.<p></p&gt

Results of a reevaluation of cardiovascular outcomes in the RECORD trial

Background The US Food and Drug Administration (FDA) required a reevaluation of cardiovascular (CV) outcomes in the RECORD trial. This provided an opportunity to assess the implications of event adjudication by 2 groups and quantify the differences as well as to use new FDA end point definitions in development.<p></p> Methods Original data were used to systematically identify all potential deaths, myocardial infarctions (MIs), and strokes. Site investigators were approached for additional source documents and information about participants lost to follow-up. Suspected events were adjudicated using standard procedures, and the results were compared with the original trial outcomes.<p></p> Results Follow-up for mortality was 25,833 person-years, including an additional 328 person-years identified during the reevaluation effort. A total of 184 CV or unknown-cause deaths (88 rosiglitazone, 96 metformin/sulfonylurea), 128 participants with an MI (68 rosiglitazone, 60 metformin/sulfonylurea), and 113 participants with a stroke (50 rosiglitazone, 63 metformin/sulfonylurea) were included. The hazard ratio (HR) for rosiglitazone versus metformin/sulfonylurea for the end point of CV (or unknown cause) death, MI, or stroke was 0.95 (95% CI 0.78-1.17) compared with 0.93 (95% CI 0.74-1.15) for the original RECORD results. Treatment comparisons for MI (HR 1.13, 95% CI 0.80-1.59) and mortality (HR 0.86, 95% CI 0.68-1.08) were also the same compared with the original RECORD results. Sensitivity analyses were also consistent with the original RECORD results. Analyses using the FDA definitions showed similar results.<p></p> Conclusions Only a modest number of additional person-years of follow-up were ascertained from this reevaluation of CV end points in RECORD. Observed HRs and CIs from these analyses using the original RECORD or new FDA end point definitions showed similar treatment effects of rosiglitazone compared with the original RECORD results.<p></p&gt

Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL) : Study design and baseline data

Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. Methods: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin 700 μg/L and/or TSAT ≥40%) or a reactive, low-dose IV iron arm (iron sucrose administered if ferritin <200 μg/L or TSAT < 20%). We hypothesized that proactive, high-dose IV iron would be noninferior to reactive, low-dose IV iron for the primary outcome of first occurrence of nonfatal myocardial infarction (MI), nonfatal stroke, hospitalization for heart failure or death from any cause. If noninferiority is confirmed with a noninferiority limit of 1.25 for the hazard ratio of the proactive strategy relative to the reactive strategy, a test for superiority will be carried out. Secondary outcomes include infection-related endpoints, ESA dose requirements, and quality-of-life measures. As an event-driven trial, the study will continue until at least 631 primary outcome events have accrued, but the expected duration of follow-up is 2-4 years. Results: Of the 2,589 patients screened across 50 UK sites, 2,141 (83%) were randomized. At baseline, 65.3% were male, the median age was 65 years, and 79% were white. According to eligibility criteria, all patients were on ESA at screening. Prior stroke and MI were present in 8 and 9% of the cohort, respectively, and 44% of patients had diabetes at baseline. Baseline data for the randomized cohort were generally concordant with recent data from the UK Renal Registry. Conclusions: PIVOTAL will provide important information about the optimum dosing of IV iron in HD patients representative of usual clinical practice. Trial Registration: EudraCT number: 2013-002267-25.Peer reviewedFinal Published versio