3,487 research outputs found

    The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD

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    Objective The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). Methods 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34+/KDR+ cells. Results Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. Conclusions Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis

    Reductions in turbidity and Escherichia coli density using passive polymer treatment

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    Current research shows sediment basins may act as reservoirs for potentially harmful bacteria, including Escherichia coli (E. coli). E. coli preferentially attach to clay-sized particles and have been found in sediment basin outflows with high turbidity levels containing concentrations exceeding water quality standards recommended by the US Environmental Protection Agency. Since research shows E. coli preferentially attach to the clay fraction within sediment, it was hypothesized that a reduction in turbidity and TSS would create a corresponding reduction in bacterial density.  Construction site sediment basin discharge was simulated to determine whether a sediment tube configuration using anionic polymer application could reduce E. coli densities. Based on prior research, reductions in turbidity and suspended sediment were maximized by applying 100 g of granular polyacrylamide (PAM) directly to each of five sediment tubes before simulated runoff events. PAM application successfully reduced turbidity and TSS by 96% and 92%, respectively. Discharge after the last sediment tube had an average turbidity of 80 NTU and TSS of 174 mg/L.  For the low E. coli density range (5,000–10,000 MPN/100 mL), PAM application failed to create a reduction in bacterial density, but rather an increase in E. coli was observed with an average discharge of 25,226 MPN/100 mL.  Within the high E. coli density range (100,000-200,000 MPN/100 mL), a 29% reduction was recorded with an average discharge of 135, 270 MPN/100 mL

    The effect of Holstein-Friesian genotype and feeding system on selected performance parameters of dairy cows on grass-based systems of milk production in Ireland

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    End of project reportThe overall objective of this project was to assess, the effect of strain of Holstein-Friesian dairy cow, pasture-based feed system (FS) and their interaction on animal performance in terms of milk productivity and lactation profile, body weight (BW), body condition score (BCS), feed intake and energy balance (EB), reproductive performance and overall economic profitability

    Interfirm supply chains: The contribution of management accounting

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    It has been argued that 'traditional' management accounting systems do not readily support supply- chain management perspectives. Our study of the implications of supply-chain management initiatives for management accounting and for management accountants both supports that criticism and shows how management accounting is changing in response to the challenges

    Protecting Crowded Places from Terrorism: An analysis of the current considerations and barriers inhibiting the adoption of counter terrorism protective security measures

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    © 2018, © 2018 Taylor & Francis Group, LLC. While much of the literature concerning counterterrorism focuses on policies and strategies aimed at removing either the terrorist environment and/or the groups or individuals willing to utilize political violence to achieve their goal(s), there is a much smaller body of work concerned with antiterrorism, namely those defensive measures that are designed to prevent or deter terrorist attacks. Increasingly, crowded places have become popular targets for terrorists and the research presented in this article connects the planning, design, and development of real estate with respect to the adoption of protective counterterrorism measures. It seeks to develop new understandings of the considerations that real estate developments have toward terrorism, as well as the barriers that may inhibit counterterrorism protective security measures in future development projects. The analysis is based on qualitative research, namely semi-structured interviews conducted in the United Kingdom, United States, and Australia with professionals involved in all core strands of the real estate development process. The findings suggest that considerations toward terrorism vary considerably as a consequence of a range of factors and that while expected factors such as cost and aesthetics are important determinants for decision making, a range of other barriers exist
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