3,116 research outputs found
The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance
The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography. These compounds as well as the Samorin mixture and the other phenanthridine trypanocide, homidium, were tested on Trypanosoma congolense and wild type, diamidine- and isometamidium-resistant Trypanosoma brucei brucei strains using an Alamar blue drug sensitivity assay. EC50 values obtained suggest that M&B4180A (2) was the most active of the components, followed by M&B38897 (1) in all the strains tested, whereas M&B4596 (4) was inactive. Samorin was found to be significantly more active than any of the individual components alone, against T. congolense and all three T. b, brucei strains. Samorin and all its active constituents displayed reduced activity against the previously characterised isometamidium-resistant strain ISMR1
The HST Key Project on the Extragalactic Distance Scale XXV. A Recalibration of Cepheid Distances to Type Ia Supernovae and the Value of the Hubble Constant
Cepheid-based distances to seven Type Ia supernovae (SNe)-host galaxies have
been derived using the standard HST Key Project on the Extragalactic Distance
Scale pipeline. For the first time, this allows for a transparent comparison of
data accumulated as part of three different HST projects, the Key Project, the
Sandage et al. Type Ia SNe program, and the Tanvir et al. Leo I Group study.
Re-analyzing the Tanvir et al. galaxy and six Sandage et al. galaxies we find a
mean (weighted) offset in true distance moduli of 0.12+/-0.07 mag -- i.e., 6%
in linear distance -- in the sense of reducing the distance scale, or
increasing H0. Adopting the reddening-corrected Hubble relations of Suntzeff et
al. (1999), tied to a zero point based upon SNe~1990N, 1981B, 1998bu, 1989B,
1972E and 1960F and the photometric calibration of Hill et al. (1998), leads to
a Hubble constant of H0=68+/-2(random)+/-5(systematic) km/s/Mpc. Adopting the
Kennicutt et al. (1998) Cepheid period-luminosity-metallicity dependency
decreases the inferred H0 by 4%. The H0 result from Type Ia SNe is now in good
agreement, to within their respective uncertainties, with that from the
Tully-Fisher and surface brightness fluctuation relations.Comment: Accepted for publication in The Astrophysical Journal. 62 pages,
LaTeX, 9 Postscript figures. Also available at
http://casa.colorado.edu/~bgibson/publications.htm
The Extragalactic Distance Scale Key Project XXVII. A Derivation of the Hubble Constant Using the Fundamental Plane and Dn-Sigma Relations in Leo I, Virgo, and Fornax
Using published photometry and spectroscopy, we construct the fundamental
plane and D_n-Sigma relations in Leo I, Virgo and Fornax. The published Cepheid
P-L relations to spirals in these clusters fixes the relation between angular
size and metric distance for both the fundamental plane and D_n-Sigma
relations. Using the locally calibrated fundamental plane, we infer distances
to a sample of clusters with a mean redshift of cz \approx 6000 \kms, and
derive a value of H_0=78+- 5+- 9 km/s/Mpc (random, systematic) for the local
expansion rate. This value includes a correction for depth effects in the
Cepheid distances to the nearby clusters, which decreased the deduced value of
the expansion rate by 5% +- 5%. If one further adopts the metallicity
correction to the Cepheid PL relation, as derived by the Key Project, the value
of the Hubble constant would decrease by a further 6%+- 4%. These two sources
of systematic error, when combined with a +- 6% error due to the uncertainty in
the distance to the Large Magellanic Cloud, a +- 4% error due to uncertainties
in the WFPC2 calibration, and several small sources of uncertainty in the
fundamental plane analysis, combine to yield a total systematic uncertainty of
+- 11%. We find that the values obtained using either the CMB, or a flow-field
model, for the reference frame of the distant clusters, agree to within 1%. The
Dn-Sigma relation also produces similar results, as expected from the
correlated nature of the two scaling relations. A complete discussion of the
sources of random and systematic error in this determination of the Hubble
constant is also given, in order to facilitate comparison with the other
secondary indicators being used by the Key Project.Comment: 21 pages, 3 figures, Accepted for publication in Ap
When Is a Bulge Not a Bulge? Inner Disks Masquerading as Bulges in NGC 2787 and NGC 3945
We present a detailed morphological, photometric, and kinematic analysis of
two barred S0 galaxies with large, luminous inner disks inside their bars. We
show that these structures, in addition to being geometrically disk-like, have
exponential profiles (scale lengths 300--500 pc) distinct from the
central, non-exponential bulges. We also find them to be kinematically
disk-like. The inner disk in NGC 2787 has a luminosity roughly twice that of
the bulge; but in NGC 3945, the inner disk is almost ten times more luminous
than the bulge, which itself is extremely small (half-light radius
100 pc, in a galaxy with an outer ring of radius 14 kpc) and only
5% of the total luminosity -- a bulge/total ratio much more typical of
an Sc galaxy. We estimate that at least 20% of (barred) S0 galaxies may have
similar structures, which means that their bulge/disk ratios may be
significantly overestimated. These inner disks dominate the central light of
their galaxies; they are at least an order of magnitude larger than typical
``nuclear disks'' found in ellipticals and early-type spirals. Consequently,
they must affect the dynamics of the bars in which they reside.Comment: LaTeX, 37 pages, 14 EPS figures. To appear in The Astrophysical
Journal (November 10, 2003 issue). Version with full-resolution figures
available at http://www.iac.es/galeria/erwin/research
The HST Key Project on the Extragalactic Distance Scale. XXVIII. Combining the Constraints on the Hubble Constant
Since the launch of the Hubble Space Telescope nine years ago, Cepheid
distances to 25 galaxies have been determined for the purpose of calibrating
secondary distance indicators. A variety of these can now be calibrated, and
the accompanying papers by Sakai, Kelson, Ferrarese, and Gibson employ the full
set of 25 galaxies to consider the Tully-Fisher relation, the fundamental plane
of elliptical galaxies, Type Ia supernovae, and surface brightness
fluctuations.
When calibrated with Cepheid distances, each of these methods yields a
measurement of the Hubble constant and a corresponding measurement uncertainty.
We combine these measurements in this paper, together with a model of the
velocity field, to yield the best available estimate of the value of H_0 within
the range of these secondary distance indicators and its uncertainty.
The result is H_0 = 71 +/- 6 km/sec/Mpc. The largest contributor to the
uncertainty of this 67% confidence level result is the distance of the Large
Magellanic Cloud, which has been assumed to be 50 +/- 3 kpc
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Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis
Background
UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential.
Aims
Describe the development, implementation and results of this questionnaire.
Method
An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use.
Results
A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45â82 (53% were â„65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation.
Conclusions
The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health
The Hubble Space Telescope Extragalactic Distance Scale Key Project. X. The Cepheid Distance to NGC 7331
The distance to NGC 7331 has been derived from Cepheid variables observed
with HST/WFPC2, as part of the Extragalactic Distance Scale Key Project.
Multi-epoch exposures in F555W (V) and F814W (I), with photometry derived
independently from DoPHOT and DAOPHOT/ALLFRAME programs, were used to detect a
total of 13 reliable Cepheids, with periods between 11 and 42 days. The
relative distance moduli between NGC 7331 and the LMC, imply an extinction to
NGC 7331 of A_V = 0.47+-0.15 mag, and an extinction-corrected distance modulus
to NGC 7331 of 30.89+-0.14(random) mag, equivalent to a distance of 15.1 Mpc.
There are additional systematic uncertainties in the distance modulus of +-0.12
mag due to the calibration of the Cepheid Period-Luminosity relation, and a
systematic offset of +0.05+-0.04 mag if we applied the metallicity correction
inferred from the M101 results of Kennicutt et al 1998.Comment: To be published in The Astrophysical Journal, 1998 July 1, v501 note:
Figs 1 and 2 (JPEG files) and Fig 7 (multipage .eps file) need to be
viewed/printed separatel
Big Corrections from a Little Higgs
We calculate the tree-level expressions for the electroweak precision
observables in the SU(5)/SO(5) littlest Higgs model. The source for these
corrections are the exchange of heavy gauge bosons, explicit corrections due to
non-linear sigma-model dynamics and a triplet Higgs VEV. Weak isospin violating
contributions are present because there is no custodial SU(2) global symmetry.
The bulk of these weak isospin violating corrections arise from heavy gauge
boson exchange while a smaller contribution comes from the triplet Higgs VEV. A
global fit is performed to the experimental data and we find that throughout
the parameter space the symmetry breaking scale is bounded by f > 4 TeV at 95%
C.L. Stronger bounds on f are found for generic choices of the high energy
gauge couplings. We find that even in the best case scenario one would need
fine tuning of less than a percent to get a Higgs mass as light as 200 GeV.Comment: 20 pages, 5 figures included, typos fixed, comments on the effects of
extra vector-like heavy fermions adde
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