Method and apparatus for reducing microwave oscillator output noise

Microwave oscilltors incorporate r.f. feedback with carrier suppression to reduce phase noise. In a direct feedback oscillator arrngement a circulator is interposed between the r.f. amplifier and the high-Q resonator. The amplifier output is applied to the slightly over-coupled input port of the resonator so that the resultant net return signal is the vectorial difference between the signals emitted and reflected from the resonator. The gain of the r.f. amplifier is chosen to regenerate the forward signal from the net return signal. In a STALO-type arrangement, the resonator is critically coupled and an r.f. amplifier added to the path of the net return signal. The sensitivity of the STALO-type feedback loop is thereby enhanced while added amplifier noise is minimized by the superposition of the signals emitted by and reflected from the resonator

Molecular landscapes of human hematopoietic stem cells in health and leukemia.

Blood cells are organized as a hierarchy with hematopoietic stem cells (HSCs) at the root. The advent of genomic technologies has opened the way for global characterization of the molecular landscape of HSCs and their progeny, both in mouse and human models, at the genetic, transcriptomic, epigenetic, and proteomics levels. Here, we outline our current understanding of the molecular programs that govern human HSCs and how dynamic changes occurring during HSC differentiation are necessary for well-regulated blood formation under homeostasis and upon injury. A large body of evidence is accumulating on how the programs of normal hematopoiesis are modified in acute myeloid leukemia, an aggressive adult malignancy driven by leukemic stem cells. We summarize these findings and their clinical implications.The authors would like to thank Emily Calderbank for critical review of the manuscript. Research in EL laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute.This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/nyas.1298

Status of the Stony Brook Superconducting Heavy-Ion Linac

The present status of the Stony Brook Superconducting Heavy-Ion Linear Accelerator is described, with emphasis on recent operational results with a prototype unit of the accelerator. The basic LINAC elements are independently-phased lead-plated copper split-loop resonators operating at 151.7 MHz and optimized for velocities of either ß=v/c= 0.055 or ß=0.10. Resonators are grouped in units of either 4 low-ß or 3 high-ß resonators in compact cryostat modules separated by room-temperature quadrupole-doublet lenses. The LINAC consisting of 4 low-ß and 7 high-ß modules injected with heavy ions of mass A≃16-100 from the Stony Brook EN tandem will produce an additional energy gain of ~18 MeV per unit charge with a total heat dissipation at 4.5K of <300 Watts. In recent tests with low-ß prototype units, individual resonators were operated continuously at accelerating gradients in excess of 3.5 MV/m, and were phase and amplitude stabilized at 3.0 MV/ m using 175 Watts of RF power. Helium-temperature dissipation at 3.0 MV/m is ~8 Watts after helium-gas conditioning. The prototype low-ß module was used to accelerate a 30 Mev ^(16)O^(5+) beam to ~35 MeV

Early Contrast Enhancement: a novel Magnetic Resonance Imaging biomarker of pleural malignancy

Introduction: Pleural Malignancy (PM) is often occult on subjective radiological assessment. We sought to define a novel, semi-objective Magnetic Resonance Imaging (MRI) biomarker of PM, targeted to increased tumour microvessel density (MVD) and applicable to minimal pleural thickening. Materials and methods: 60 consecutive patients with suspected PM underwent contrast-enhanced 3-T MRI then pleural biopsy. In 58/60, parietal pleura signal intensity (SI) was measured in multiple regions of interest (ROI) at multiple time-points, generating ROI SI/time curves and Mean SI gradient (MSIG: SI increment/time). The diagnostic performance of Early Contrast Enhancement (ECE; which was defined as a SI peak in at least one ROI at or before 4.5 min) was compared with subjective MRI and Computed Tomography (CT) morphology results. MSIG was correlated against tumour MVD (based on Factor VIII immunostain) in 31 patients with Mesothelioma. Results: 71% (41/58) patients had PM. Pleural thickening was &#60;10 mm in 49/58 (84%). ECE sensitivity was 83% (95% CI 61–94%), specificity 83% (95% CI 68–91%), positive predictive value 68% (95% CI 47–84%), negative predictive value 92% (78–97%). ECE performance was similar or superior to subjective CT and MRI. MSIG correlated with MVD (r = 0.4258, p = .02). Discussion: ECE is a semi-objective, perfusion-based biomarker of PM, measurable in minimal pleural thickening. Further studies are warranted

The Ursinus Weekly, April 27, 1953

Y to sponsor panel meeting with Albright • Price, Merrifield, Haines, Hartman to head WSGA, WAA, YWCA, YMCA • May Day dancers prepare pageant for gala weekend • Concert presented by Meistersingers • Fraternities plan May dinner dances • Sororities make plans for shore visits, dinner dances • Group plays to be given • Eight win full scholarships • French teachers\u27 conference held at Ursinus, April 25 • Thespians to give Two blind mice • Friedlin crowned queen; Cub & Key honors five • Radomski, Wong elected to pre-med society offices • Class and council petitioning ends Friday • Jones reads from works of Noyes and Lindsay on Tuesday • Editorials: Tradition vs. common sense • I love Spring! • Helfferich named to board • Career offer for grads • Letters to the editor • Are you wasting money? • Alumni news • U.C. co-ed gives inside scoop on life in a boys\u27 dormitory • Ursinus professors are authorities in subject fields • From memoirs of a freshman: A visit to the Supply Store • Bears drop track meet to West Chester, 69-57 • Bryn Mawr tops girls in tennis • Baseball team loses, 8-7; But tops Graterford, 7-3 • East Stroudsburg routs Belles, 5-0 • Men\u27s tennis team loses, 5-4 • Belles, Albright vie in softball opener • Court squad downs Chestnut Hill, 5-0 • Hutch twirls shut-out; Bears beat Pharmacy, 20-0https://digitalcommons.ursinus.edu/weekly/1518/thumbnail.jp

The Ursinus Weekly, November 17, 1952

Faculty show is considered huge success • Dean addresses freshman class • Bus. Ad. Club sponsors debate on current economic issues • Y cabinet hears program plans of commissions • Dorm reps chosen to sell yearbooks • Speaker explains international bank • 11 articles, three books left in lost and found department • Ruby to give show on Friday • Benefit fashion show enjoyed by audience • I.R.C. attends model U.N. • Chest Drive opens today; $1300 set as final goal • Two Messiah soloists chosen • Lord to speak at Forum on November 25 • Freshmen petition to give breakage fees to Union • Rev. James tells What on earth God is doing • Alpha Psi sees play • Kratz, Moser describe Paris to French Club • Marine captain to speak • Editorials: Fashionable trend?; Let\u27s all give • No more expansiveness • Don Juan in Hell judged fine show • Engagements • Scribe reviews Russian movie • F.T.A. holds roast • Not as dead as you think claims fightin\u27st college • Time for change; Ursinus in 1870 • Go west young man ; Dawkins finds rare rattler • Snell\u27s Belles defeat Chestnut Hill in shutout • Court men begin pre-season drills • Drexel defeats Ursinus in final home tilt, 7-1 • Bakermen close season with 7-2 loss to Lehigh • Bears to try for equalizing victory • Juniata topples Bears in rain and mud, 7-0 • Two Ursinus Belles honored • Playoffs to decide champhttps://digitalcommons.ursinus.edu/weekly/1506/thumbnail.jp

The Maine Annex, vol. 2, no. 11

The Maine Annex begins to discuss the House Committee on Un-American Activities (HCUA), growing fears of private and public citizens suspected of fascist or communist activities, and whether war with Russia was inevitable. The paper also notes the pending presentation about Islam by British Army officer and adventurer Colonel R. V. C. Bodley

Mylonitic deformation at the Kane oceanic core complex : implications for the rheological behavior of oceanic detachment faults

Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 14 (2013): 3085–3108, doi:10.1002/ggge.20184.The depth extent, strength, and composition of oceanic detachment faults remain poorly understood because the grade of deformation-related fabrics varies widely among sampled oceanic core complexes (OCCs). We address this issue by analyzing fault rocks collected from the Kane oceanic core complex at 23°30′N on the Mid-Atlantic Ridge. A portion of the sample suite was collected from a younger fault scarp that cuts the detachment surface and exposes the interior of the most prominent dome. The style of deformation was assessed as a function of proximity to the detachment surface, revealing a ∼450 m thick zone of high-temperature mylonitization overprinted by a ∼200 m thick zone of brittle deformation. Geothermometry of deformed gabbros demonstrates that crystal-plastic deformation occurred at temperatures >700°C. Analysis of the morphology of the complex in conjunction with recent thermochronology suggests that deformation initiated at depths of ∼7 km. Thus we suggest the detachment system extended into or below the brittle-plastic transition (BPT). Microstructural evidence suggests that gabbros and peridotites with high-temperature fabrics were dominantly deforming by dislocation-accommodated processes and diffusion creep. Recrystallized grain size piezometry yields differential stresses consistent with those predicted by dry-plagioclase flow laws. The temperature and stress at the BPT determined from laboratory-derived constitutive models agree well with the lowest temperatures and highest stresses estimated from gabbro mylonites. We suggest that the variation in abundance of mylonites among oceanic core complexes can be explained by variation in the depth of the BPT, which depends to a first order on the thermal structure and water content of newly forming oceanic lithosphere.Knorr Cruise 180-2 data and sample acquisition was supported by NSF grant 0118445.2014-02-2