Appendix B: Some morphometric parameters of named lakes with areas [greater than or equal to] 1.0 km2, and some smaller lakes, in New Zealand

Gaps indicate uncertainty or that accurate data are unavailable. Note that lakes with fluctuating levels e.g., those used for hydro-electric purposes, or near coasts have varying parameters. Table based mainly on Irwin (1975) with some data from Cunningham et al. (1953), Irwin (1972), Jolly & Brown (1975), Irwin & Pickrill (1983), Howard-Williams & Vincent 1984, Boswell et al. (1985), Livingstone et al. (1986), N.Z.O.I. Lake Chart series, N.Z. Topographical Map Series NZMS1 (1:63 360) and NZMS26O (1:50 000), and other sources

Stratigraphy and development of c. 17 000 year old Lake Maratoto, North Island, New Zealand, with some inferences about postglacial climatic change

The stratigraphy and geomorphology of Lake Maratoto and its surrounds were investigated as part of a programme of paleolimnological studies based on sediment cores from lakes in northern North Island. Changes in the lake and catchment were inferred from variations in sediment character, the correlation and timing being determined from distinctive tephra layers in the sediments and by radiocarbon dating. Nineteen new C-l4 dates, on gyttja or peat, are reported (old T½, years B.P,): 11 on tephras (Mamaku Ash 6830 ±90. Wk227; Rotoma Ash 8370 ± 90, Wk522; 8350 ± 100, Wk523; Opepe Tephra 9370 ± 210, Wk230; Mangamate Tephra 9700 ± 140, Wk23l; 10000 ± 120, Wk232; Waiohau Ash 12 200 ± 230, Wk233; 12500 ± 190, Wk234; 12450 ± 200, Wk5l5; 12300 ± 190,Wk516; RotoruaAsh 13450 ± 120, Wk511); 5 on the deposition of Hinuera Formation alluvium (16 300 ± 250, Wk239; 16 900 ± 470, Wk240; 17050 ± 200, Wk358; 16200 +360 -340, Wk509; 15 850 ± 130, Wk510); and 3 on basal peat of the Rukuhia bog (10 250 ± 90, Wk114; 15200 ± 130, Wk534; 10600 ± 90, Wk553). Lake Maratoto originated c. 17 000 years ago when a small valley was dammed by volcanogenic alluvium (Hinuera Formation). From c. 17 000 to c. 14 000 years ago the lake was about 2 m deep with clear water. Marginal peat first developed at c. 15000 years ago, reducing the area of the lake by about one-half by c. 13 000 years ago. Lake area then expanded, possibly because of marginal erosion and/or oxidation of the peat, to its maximum size at the present day. The adjacent Rukuhia peat bog grew rapidly from c. 11 000 years ago and is now 8 m thick immediately to the west of the lake. As a result of this growth, the lake became dystrophic and deepened (3.5 m at c. 7000 years ago, 6.4 m at c. 2000 years ago, and 7. 1 m today). The developmental history suggests that net precipitation increased at c. 15 000 years ago, increased further at c. 11 000 years ago, remaining high to c. 7000 years ago at least, but with a decline at or before c. 2000 years ago. There may have been a distinctly wetter or windier period from c. 10 000 to 9000 years ago. This interpretation is consistent with other reconstructions of postglacial climate in the Southern Hemisphere

Lakes

Lakes have always held an aesthetic fascination for people; they figure prominently in both art and literature and have even been endowed with spiritual qualities. For example, the nineteenth century American writer Henry D. Thoreau (1854) considered a lake to be 'the landscape's most beautiful and expressive feature. It is the earth's eye; looking into which the beholder measures the depth of his own nature'. More prosaically, lakes are also of considerable geomorphological interest as dynamic landfonns originating in varied and often complex ways

Palynology, vegetation and climate of the Waikato lowlands, North Island, New Zealand, since c. 18,000 years ago

The vegetational and climatic history of the Waikato lowlands during the last c. 18,000 years is inferred from the palynology of sediment cores from Lakes Rotomanuka, Rotokauri, and Okoroire. Intra- and inter-lake correlations were aided by multiple tephra layers interbedded with the lake sediments. The detailed chronological resolution given by these tephra sequences shows that late glacial-post glacial vegetational and climatic changes were nearly simultaneous throughout the Waikato lowlands

Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients

Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response. However, their immunosuppressive function remains poorly understood within the tumour microenvironment and this study aimed to address this. Methods: The frequency and suppressive capacity of two CD4?CD127low/- Treg populations, separated on the basis of different levels of CD25 expression (CD25inter and CD25high), from the tumour/node microenvironment and peripheral circulation of newly-presenting head and neck squamous cell carcinoma patients (n=19), were assessed using multicolour flow cytometry. Results: The proportion of Tregs (CD4?CD25high/?interCD127low/-) in the tumour/node microenvironment was significantly elevated compared with the peripheral circulation (p<0.001) and similar percentages were present in both the primary tumour and metastatic lymph node. The percentage of suppression induced by Tregs isolated from tumour associated nodes on the proliferation of nodal effector T cells was similar to that of peripheral Tregs on peripheral effector T cells. However, when the suppressive activity of both nodal and peripheral Tregs was compared on the same peripheral effectors, peripheral Tregs suppressed proliferation to a greater extent. Conclusion: This work shows that the recruitment and percentages of tumour infiltrating Tregs are key factors in modulating the immune environment of head and neck tumours

S18RS SGR No. 6 (Solar Power)

A RESOLUTION To urge and request LSU Facility and Property Oversight to pursue and sign a solar purchase power agreement with a solar technology develope

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be improved if a patient's tumour response to irradiation could be predicted ex vivo before clinical application. The present study employed a bespoke microfluidic device to maintain HNSCC tissue whilst subjecting it to external beam irradiation and measured the responses using a panel of cell death and proliferation markers. HNSCC biopsies from five newly-presenting patients [2 lymph node (LN); 3 primary tumour (PT)] were divided into parallel microfluidic devices and replicates of each tumour were subjected to single-dose irradiation (0, 5, 10, 15 and 20 Gy). Lactate dehydrogenase (LDH) release was measured and tissue sections were stained for cytokeratin (CK), cleaved-CK18 (cCK18), phosphorylated-H2AX (λH2AX) and Ki.67 by immunohistochemistry. In addition, fragmented DNA was detected using terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL). Compared with non.irradiated controls, higher irradiation doses resulted in elevated CK18-labelling index in two lymph nodes [15 Gy; 34.8% on LN1 and 31.7% on LN2 (p=0.006)] and a single laryngeal primary tumour (20 Gy; 31.5%; p=0.014). Significantly higher levels of DNA fragmentation were also detected in both lymph node samples and one primary tumour but at varying doses of irradiation, i.e., LN1 (20 Gy; 27.6%; p=0.047), LN2 (15 Gy; 15.3%; p=0.038) and PT3 (10 Gy; 35.2%; p=0.01). The λH2AX expression was raised but not significantly in the majority of samples. The percentage of Ki.67 positive nuclei reduced dose-dependently following irradiation. In contrast no significant difference in LDH release was observed between irradiated groups and controls. There is clear interand intra-patient variability in response to irradiation when measuring a variety of parameters, which offers the potential for the approach to provide clinically valuable information

Practitioners Need Broader Expertise: Real Estate Law is Undergoing Profound Changes

This article discusses the sweeping modifications to real estate law practice as legislators, courts, and lawyers attempt to accommodate a number of real world challenges. The authors’ discussion analyzes several of these transitioning influences, such as an increase in environmental concerns, shifts in environmental legislation, the subprime mortgage crisis, the effect Kelo v. New London has on the lawyers’ role in facilitating redevelopment, as well as the influence of new E-sign laws has on drafting real estate documents