2 research outputs found
Enantioselective Rhodium-Catalyzed Isomerization of 4‑Iminocrotonates: Asymmetric Synthesis of a Unique Chiral Synthon
An
enantioselective isomerization of 4-iminocrotonates catalyzed
by a rhodiumÂ(I)/phosphoramidite complex is described. This reaction
uses widely available amines to couple with 4-oxocrotonate to provide
a convenient access to a central chiral building block in good yield
and high enantioselectivity. Although the mechanism of this new transformation
remains unclear, both Rh and the phosphoramidite play a central role