Enantioselective Rhodium-Catalyzed Isomerization of 4‑Iminocrotonates: Asymmetric Synthesis of a Unique Chiral Synthon

Abstract

An enantioselective isomerization of 4-iminocrotonates catalyzed by a rhodium­(I)/phosphoramidite complex is described. This reaction uses widely available amines to couple with 4-oxocrotonate to provide a convenient access to a central chiral building block in good yield and high enantioselectivity. Although the mechanism of this new transformation remains unclear, both Rh and the phosphoramidite play a central role