Effect of yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers

<p>Abstract</p> <p>Background</p> <p>Probiotics are used to provide health benefits. The present study tested the effect of a probiotic yoghurt on faecal output of beta-defensin and immunoglobulin A in a group of young healthy women eating a defined diet.</p> <p>Findings</p> <p>26 women aged 18-21 (median 19) years residing in a hostel were given 200 ml normal yoghurt every day for a week, followed by probiotic yoghurt containing <it>Bifidobacterium lactis </it>Bb12^®(10⁹in 200 ml) for three weeks, followed again by normal yoghurt for four weeks. Stool samples were collected at 0, 4 and 8 weeks and assayed for immunoglobulin A and human beta-defensin-2 by ELISA. All participants tolerated both normal and probiotic yoghurt well. Human beta-defensin-2 levels in faeces were not altered during the course of the study. On the other hand, compared to the basal sample, faecal IgA increased during probiotic feeding (P = 0.0184) and returned to normal after cessation of probiotic yoghurt intake.</p> <p>Conclusions</p> <p><it>Bifidobacterium lactis </it>Bb12^®increased secretory IgA output in faeces. This property may explain the ability of probiotics to prevent gastrointestinal and lower respiratory tract infections.</p

The fifth data release of the Kilo Degree Survey: Multi-epoch optical/NIR imaging covering wide and legacy-calibration fields

\ua9 The Authors 2024.We present the final data release of the Kilo-Degree Survey (KiDS-DR5), a public European Southern Observatory (ESO) wide-field imaging survey optimised for weak gravitational lensing studies. We combined matched-depth multi-wavelength observations from the VLT Survey Telescope and the VISTA Kilo-degree INfrared Galaxy (VIKING) survey to create a nine-band optical-to-near-infrared survey spanning 1347 deg2. The median r-band 5σlimiting magnitude is 24.8 with median seeing 0.7″. The main survey footprint includes 4 deg2 of overlap with existing deep spectroscopic surveys. We complemented these data in DR5 with a targeted campaign to secure an additional 23 deg2 of KiDS- and VIKING-like imaging over a range of additional deep spectroscopic survey fields. From these fields, we extracted a catalogue of 126 085 sources with both spectroscopic and photometric redshift information, which enables the robust calibration of photometric redshifts across the full survey footprint. In comparison to previous releases, DR5 represents a 34% areal extension and includes an i-band re-observation of the full footprint, thereby increasing the effective i-band depth by 0.4 magnitudes and enabling multi-epoch science. Our processed nine-band imaging, single- and multi-band catalogues with masks, and homogenised photometry and photometric redshifts can be accessed through the ESO Archive Science Portal

Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study

BackgroundFrontotemporal lobar degeneration (FTLD) is a leading cause of dementia in individuals aged &lt;65 years. Several challenges to conducting in-person evaluations in FTLD illustrate an urgent need to develop remote, accessible, and low-burden assessment techniques. Studies of unobtrusive monitoring of at-home computer use in older adults with mild cognitive impairment show that declining function is reflected in reduced computer use; however, associations with smartphone use are unknown.ObjectiveThis study aims to characterize daily trajectories in smartphone battery use, a proxy for smartphone use, and examine relationships with clinical indicators of severity in FTLD.MethodsParticipants were 231 adults (mean age 52.5, SD 14.9 years; n=94, 40.7% men; n=223, 96.5% non-Hispanic White) enrolled in the Advancing Research and Treatment of Frontotemporal Lobar Degeneration (ARTFL study) and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS study) Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Mobile App study, including 49 (21.2%) with mild neurobehavioral changes and no functional impairment (ie, prodromal FTLD), 43 (18.6%) with neurobehavioral changes and functional impairment (ie, symptomatic FTLD), and 139 (60.2%) clinically normal adults, of whom 55 (39.6%) harbored heterozygous pathogenic or likely pathogenic variants in an autosomal dominant FTLD gene. Participants completed the Clinical Dementia Rating plus National Alzheimer's Coordinating Center Frontotemporal Lobar Degeneration Behavior and Language Domains (CDR+NACC FTLD) scale, a neuropsychological battery; the Neuropsychiatric Inventory; and brain magnetic resonance imaging. The ALLFTD Mobile App was installed on participants' smartphones for remote, passive, and continuous monitoring of smartphone use. Battery percentage was collected every 15 minutes over an average of 28 (SD 4.2; range 14-30) days. To determine whether temporal patterns of battery percentage varied as a function of disease severity, linear mixed effects models examined linear, quadratic, and cubic effects of the time of day and their interactions with each measure of disease severity on battery percentage. Models covaried for age, sex, smartphone type, and estimated smartphone age.ResultsThe CDR+NACC FTLD global score interacted with time on battery percentage such that participants with prodromal or symptomatic FTLD demonstrated less change in battery percentage throughout the day (a proxy for less smartphone use) than clinically normal participants (P&lt;.001 in both cases). Additional models showed that worse performance in all cognitive domains assessed (ie, executive functioning, memory, language, and visuospatial skills), more neuropsychiatric symptoms, and smaller brain volumes also associated with less battery use throughout the day (P&lt;.001 in all cases).ConclusionsThese findings support a proof of concept that passively collected data about smartphone use behaviors associate with clinical impairment in FTLD. This work underscores the need for future studies to develop and validate passive digital markers sensitive to longitudinal clinical decline across neurodegenerative diseases, with potential to enhance real-world monitoring of neurobehavioral change

Quantitative Social Dialectology: Explaining Linguistic Variation Geographically and Socially

In this study we examine linguistic variation and its dependence on both social and geographic factors. We follow dialectometry in applying a quantitative methodology and focusing on dialect distances, and social dialectology in the choice of factors we examine in building a model to predict word pronunciation distances from the standard Dutch language to 424 Dutch dialects. We combine linear mixed-effects regression modeling with generalized additive modeling to predict the pronunciation distance of 559 words. Although geographical position is the dominant predictor, several other factors emerged as significant. The model predicts a greater distance from the standard for smaller communities, for communities with a higher average age, for nouns (as contrasted with verbs and adjectives), for more frequent words, and for words with relatively many vowels. The impact of the demographic variables, however, varied from word to word. For a majority of words, larger, richer and younger communities are moving towards the standard. For a smaller minority of words, larger, richer and younger communities emerge as driving a change away from the standard. Similarly, the strength of the effects of word frequency and word category varied geographically. The peripheral areas of the Netherlands showed a greater distance from the standard for nouns (as opposed to verbs and adjectives) as well as for high-frequency words, compared to the more central areas. Our findings indicate that changes in pronunciation have been spreading (in particular for low-frequency words) from the Hollandic center of economic power to the peripheral areas of the country, meeting resistance that is stronger wherever, for well-documented historical reasons, the political influence of Holland was reduced. Our results are also consistent with the theory of lexical diffusion, in that distances from the Hollandic norm vary systematically and predictably on a word by word basis

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

The awkward semantics of Facebook reactions

Facebook originally had a single reaction feature, like, which was updated in 2016 with five other options, and again in 2020 with a sixth. The intended meanings of these features remains unclear: they are both constrained in expressive range and potentially confused with one another. This study examines the distribution of these reactions across seven samples of Facebook posts to evaluate their potential meanings and assess their comparability across contexts, in terms of three current approaches to interpreting social media meanings: engagement, sentiment, and face-work. The reactions’ distribution is complex and unstable across samples and the available aggregate data does not reveal face-work patterns which are otherwise readily observable. In conclusion, cautions are offered regarding interpreting quantitative analyses of reaction features

The Flat Earth phenomenon on YouTube

An active contemporary discourse on YouTube revolves around the idea that the Earth is flat instead of round, and how Flat Earth cosmology is related to contemporary political, religious and cultural issues. Thousands of such videos have been produced, gathering multiple millions of views. Flat Earth discourse sometimes crosses into other public discourse, but YouTube remains singularly important in promoting Flat Earth belief and encouraging development of its supporting arguments. The videos at the source of this stir are highly ambiguous. I argue that this phenomenon represents fusion of multiple influences unique to YouTube, including conspiracy theory, climate change denial, science documentaries, clickbait, viral videos, trolling, Russian propaganda, and young-Earth religious fundamentalism. The phenomenon cannot be properly understood without recognizing the distinct contribution of all of these elements