Letter from John Brough to Thomas S. Armstrong

Certificate of promotion to First Lieutenant of the 122nd OVI for Thomashttps://digitalcommons.owu.edu/harvey-letters/1191/thumbnail.jp

Letter from John Brough to Thomas S. Armstrong

Document commissioning Thomas to captain of the 122nd OVIhttps://digitalcommons.owu.edu/harvey-letters/1199/thumbnail.jp

Assessment of Training Modes and Features in the Virtual Training Studio

Personal Virtual Environments display promise as training devices for many areas such as assembly/disassembly operations, maintenance training, and in situations where there are environmental hazards that workers should minimize their exposure to. However, there are several issues with training in virtual environments that need to be addressed. There is a limited understanding of how individuals learn in virtual environments and how the environments should be developed so that training is efficient and effective. Virtual Training Studio (VTS) is a virtual environment based training system developed by the University of Maryland for effectively training assembly processes in an efficient manner. This thesis details the design and implementation of the VTS system and then investigates and evaluates the use of the various training modes and features implemented in the Virtual Training Studio to determine their benefits to facilitating learning in the virtual environment. A model was also developed to predict the average training time necessary for a new user on a new tutorial. This model was developed using the data collected in the user study conducted for this thesis. The data collected and analyzed in this thesis is useful for designing the next generation of the VTS. Each learning mode and learning feature was investigated to better understand its use by several demographics representing a large percentage of its intended users. The study indicated the success of the system and validated the design objectives. Overall, the system had a 94% success rate for training users on the assembly of a mechanical device they had not seen before

Medieval diplomatic history: France and the Welsh, 1163-1417

This thesis examines French efforts to project their power onto Britain during the Middle Ages, engaging the Welsh as their partners. The subsequent chapters contribute fresh analysis on a range of leaders and periods. This has been done using new theories, particularly military ones, and pushes the boundaries of this area of studies. The concepts of ‘bracketing alliances’ and the strategy of ‘cultivate and eradicate’ have been introduced and applied to this research. In addition, the thesis includes works not commonly found in such a study; reaching outside the field to help clarify points of analysis. For example, Sun Tzu has been included to demonstrate that medieval rulers were practising the most effective methods of warfare, as we recognise them today. Also, by applying modern diplomatic theory, such as ‘Soft Power’, this research not only gives these ideas a wider conceptual use but also connects and makes relevant medieval events to the modern world. On a broader level, these French-Welsh links demand wider exposure, whether from the perspective of the French attempting to articulate their power within Britain or the Welsh playing a role on the continental stage. This thesis presents new perceptions of these leaders, the conflicts of their times, their diplomatic initiatives and the power relations of the age. Its primary thrusts, therefore, are the dissection of the form and impact of these diplomatic and military relations, focussing on French efforts to project their power onto Britain at moments when friendship was co-ordinated with Welsh leaders. In recognition of the many subjects researched, and to borrow shamelessly from William of Malmesbury, and certainly others, I give note; ‘uolo enim hoc opus esse multarum historiarum breuiarium.’

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New <i>Trypanosoma cruzi</i> Hit-Discovery Screening Cascade

<div><p>Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or through the development of new chemical entities. A key first step is the identification of compounds with anti-<i>Trypanosoma cruzi</i> activity from compound libraries. Here we describe a hit discovery screening cascade designed to specifically identify hits that have the appropriate anti-parasitic properties to warrant further development. The cascade consists of a primary imaging-based assay followed by newly developed and appropriately scaled secondary assays to predict the cidality and rate-of-kill of the compounds. Finally, we incorporated a cytochrome P450 CYP51 biochemical assay to remove compounds that owe their phenotypic response to inhibition of this enzyme. We report the use of the cascade in profiling two small libraries containing clinically tested compounds and identify Clemastine, Azelastine, Ifenprodil, Ziprasidone and Clofibrate as molecules having appropriate profiles. Analysis of clinical derived pharmacokinetic and toxicity data indicates that none of these are appropriate for repurposing but they may represent suitable start points for further optimisation for the treatment of Chagas disease.</p></div

Reviews

The following publications have been reviewed by the mentioned authors;Art and Society One. War by Ken Baynes, reviewed by Ronald FrankenbergArt and Society Two. Work by Ken Baynes and Alan Robinson, reviewed by Ronald FrankenbergArt and Society Three. Worship by Ken and Kate Baynes, reviewed by Ronald FrankenbergArt and Science by Dolf Rieser, reviewed by M. K. PaffardA COMMON SYSTEM OF EXAMINING AT 16+ by the Schols Council Examinations Bulletin No.23, reviewed by W. G. SkinnerSchool Resource Centres, the Schools Council Working Paper 43, reviewed by L. BroughA History of English Furniture by John Harrison, reviewed by S. J. EgglestonTrends in School Design by Eric Pearson, reviewed by P. K. BodenWorking Space, A Place to Paint, Language Aeas by Jason Dean, reviewed by P. K. BodenAlive to Art by Jose Llobera, reviewed by John LancasterVisual Education in the primary school by John M. Pickering, reviewed by L. BroughArt & Design Cards. Packs 1 & 2 by Ian Pillinger, reviewed by Francis ZankerWorkshop Assignments, Book One by S. Dunkerley & A. Huxton, reviewed by L. BroughStep By Step Metalwork, Book 3 by Kenneth Wells, reviewed by M. SayerIntroducing Jewellery Making by John Crawford, reviewed by John DecorteMaggie Hayes Jewellery Book by Maggie Hayes, reviewed by S. J. Egglesto

The 6df galaxy survey: The near-infrared fundamental plane of early-type galaxies

We determine the near-infrared Fundamental Plane (FP) for ~10 4 early-type galaxies in the 6-degree Field Galaxy Survey (6dFGS). We fit the distribution of central velocity dispersion, near-infrared surface brightness and half-light radius with a 3D Gaussian model using a maximum-likelihood method. The model provides an excellent empirical fit to the observed FP distribution and the method proves robust and unbiased. Tests using simulations show that it gives superior results to regression techniques in the presence of significant and correlated uncertainties in all three parameters, censoring of the data by various selection effects and outliers in the data sample. For the 6dFGS J-band sample we find an FP with Re∝σ01.52±0.03Ie-0.89±0.01, similar to previous near-infrared determinations and consistent with the H- and K-band FPs once allowance is made for differences in mean colour. The overall scatter in R e about the FP is σ r = 29 per cent, and is the quadrature sum of an 18 per cent scatter due to observational errors and a 23 per cent intrinsic scatter. Because of the Gaussian distribution of galaxies in FP space, σ r is not the distance error, which we find to be σ d = 23 per cent. Using group richness and local density as measures of environment, and morphologies based on visual classifications, we find that the FP slopes do not vary with environment or morphology. However, for fixed velocity dispersion and surface brightness, field galaxies are on average 5 per cent larger than galaxies in groups or higher density environments, and the bulges of early-type spirals are on average 10 per cent larger than ellipticals and lenticulars. The residuals about the FP show significant trends with environment, morphology and stellar population. The strongest trend is with age, and we speculate that age is the most important systematic source of offsets from the FP, and may drive the other trends through its correlations with environment, morphology and metallicity. These results will inform our use of the near-infrared FP in deriving relative distances and peculiar velocities for 6dFGS galaxies

The Group Evolution Multiwavelength Study (GEMS): the Sample and Datasets

Galaxy groups have been under-studied relative to their richer counterparts -- clusters. The Group Evolution Multiwavelength Study (GEMS) aims to redress some the balance. Here we describe the GEMS sample selection and resulting sample of 60 nearby (distance < 130 Mpc) galaxy groups and our multiwavelength dataset of X-ray, optical and HI imaging. ROSAT X-ray images of each group are presented. GEMS also utilizes near-infrared imaging from the 2MASS survey and optical spectra from the 6dFGS. These observational data are complemented by mock group catalogues generated from the latest LCDM simulations with gas physics included. Existing GEMS publications are briefly highlighted as are future publication plans.Comment: Accepted for publication in PASA. Paper plus additional figures in jpg forma