Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides

Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10–60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is important to recognize cutaneous ulceration as an uncommon, but potentially serious, side effect of methotrexate in these patients, and to differentiate it from ulceration due to progressive lymphoma

Effect of Cristobalite on the Strength of Sintered Fused Silica Above and Below the Cristobalite Transformation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111203/1/jace13505.pd

Kinetics of Cristobalite Formation in Sintered Silica

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107495/1/jace12889.pd

Returning to Learning: Adults' Success in College Is Key to America's Future

Provides an overview of research on adult learners' characteristics, risk factors, and needs at four-year institutions and in for-credit and non-credit courses, and what changes institutions and governments can implement to help adult students succeed

THEMIS Observations of the Magnetopause Electron Diffusion Region: Large Amplitude Waves and Heated Electrons

We present the first observations of large amplitude waves in a well-defined electron diffusion region at the sub-solar magnetopause using data from one THEMIS satellite. These waves identified as whistler mode waves, electrostatic solitary waves, lower hybrid waves and electrostatic electron cyclotron waves, are observed in the same 12-sec waveform capture and in association with signatures of active magnetic reconnection. The large amplitude waves in the electron diffusion region are coincident with abrupt increases in electron parallel temperature suggesting strong wave heating. The whistler mode waves which are at the electron scale and enable us to probe electron dynamics in the diffusion region were analyzed in detail. The energetic electrons (~30 keV) within the electron diffusion region have anisotropic distributions with T_{e\perp}/T_{e\parallel}>1 that may provide the free energy for the whistler mode waves. The energetic anisotropic electrons may be produced during the reconnection process. The whistler mode waves propagate away from the center of the 'X-line' along magnetic field lines, suggesting that the electron diffusion region is a possible source region of the whistler mode waves

Wood Diaphragm Deflections. Part I: Generalizing Standard Equations Using MechanicsBased Derivations for Panel Construction

Horizontal wood diaphragm systems, whether decked with conventional or mass timber panels, transfer wind and seismic loads to vertical elements of the lateral force-resisting system (LFRS), in flexible, rigid, or semi-rigid fashion. Characterizing and calculating the resulting diaphragm deflections determines the distribution of forces to critically loaded components and a significant portion of lateral building translations and rotations. Deflection equations for sheathed wood structural panel (WSP) diaphragms are well established in U.S. design standards in a 4-term expression that models flexural, shear, and fastener-slip deformations and its full derivation using principles of mechanics is provided herein. Derivations of similar equations for cross-laminated timber (CLT) diaphragms have yet to unfold, despite growing industry consensus that CLT panels make efficient slabs and decks. In this first of two companion papers, the corrected full derivation of the current 4-term WSP diaphragm deflection expression is provided and assessed, and two ways to quantify the cumulative contribution of fastener slip are presented in order to expand its usage to a wider variety of WSP and CLT configurations in current use. Building upon this generalized mechanics-based derivation, the authors are able to propose and assess in the companion paper a unified diaphragm deflection model to compute both WSP and CLT diaphragm deflections as implemented under current practice and guide further development