Report on a complaint by the former board of Wirral Metropolitan College against the FEFC

This ia a report by FEFC Ombudsma

An Assessment of an Experimental Surgery Scheme in General Practice

A study of aspects of the work and of the opinions of patients and staff was made at times over a period of two years before and one year after the opening of an experimental surgery tmit specially designed for a particular way of organising the doctor/nurse team in general practice. The investigation took place in a busy group practice of three doctors caring between them for over 9000 patients living in a London borough

Some clinical and laboratory studies of large pituitary tumours treated with dopamine agonists

The patient with a large pituitary tumour presents a number of management problems and conventional treatment with surgery and radiotherapy is unsatisfactory. Reports between 1978 and 1982 showed that some tumours regress during dopamine agonist (DA) therapy, though thiB does not produce a permanent cure (Chapter 1). The aim of the present work was to clarify the effect of DA therapy on different types of large pituitary tumour and to characterise cells from both responsive and unresponsive tumours. Three conclusions resulted from the clinical studies (Chapter 2): (1) Most macroprolactinomas shrink during DA therapy but the shrinkage is often asymmetrical and results in fibrosis during long-term therapy, both of which hamper subsequent surgery. (2) Disconnection hyperprolactinaemia may be considerable and lead to inappropriate DA therapy for non-adenomatous lesions. (3) Non-functioning tumours do not regress during DA therapy. Tumour cells were characterised by tumour cell perifusion (methods described in Chapters 3 and 4), dopamine receptor measurement using [ H]spiperone as radioligand (methods described in Chapter 5) and immunocytochemistry. Prolactin secretion rates from bromocriptinetreated macroprolactinomas were greatly reduced compared with untreated tumours. Most prolactinomas showed dose-related inhibition of prolactin secretion by dopamine and bromocriptine but one tumour was partially bromocriptine resistant in-vivo and in-vitro (Chapter 6). Fifty percent of the non-functioning tumours did not contain, secrete or immunostain for any known anterior pituitary peptide. The remainder secreted small amounts of gonadotrophins or alpha subunit, but the secretion was not inhibited by dopamine, immunostaining was confined to <102! of cells and tumour contents were low (Chapter 7). Despite their failure to regress during bromocriptine treatment, non¬ functioning tumours were shown to possess similar dopamine receptors to prolactinomas and normal anterior pituitary (Chapter 8). Using a novel immunoassay, bromocriptine was shown to be bound to non-functioning tumour dopamine receptors in-vivo. In contrast, two TSH-secreting adenomas were also unresponsive to dopaminergic manipulation but lacked membrane-bound dopamine receptors (Chapter 9). From these results, future clinical practice demands greater care in selecting patients for dopamine agonist or surgical treatments. The finding of dopamine receptors in non-functioning tumours suggests future research on these enigmatic tumours aimed at defining the cell type represented and post-dopamine receptor mechanisms (Chapter 10)

Lest We Remember/“Lest We Forget”: Gallipoli as Exculpatory Memory

Before the build-up to the centenary of the 1915 invasion of Turkey’s Gallipoli Peninsula begins in earnest, I thought it might be timely to interrogate the notion that those of us who live in Australasia are confronted with every Anzac Day: that it was on April 25, 1915, the day the Australia New Zealand Army Corps (Anzacs) landed at Gallipoli as part of the Mediterranean Expeditionary Force, that the consciousness of nationhood was born in Australia and New Zealand, This foundational idea, with specific application to Australia, was first published nine years after the event by Charles Bean, the Australian Government’s official World War I historian who is also regarded as having created the Anzac legend. On a broader view, World War I was, for Bean, about freedom, and more broadly still, about the survival of civilisation

More than just drama: the agenda of Prime Minister’s Questions

Prime Minister’s Questions is one of the most public venues for MPs to express their opinions and represent the views of their constituents. But can opposition parties and backbenchers – MPs who hold no governmental office and are not a spokesperson in the Opposition – drive the content of such questions? Shaun Bevan and Peter John address this by looking at questions between the start of the Labour government in 1997 and the end of 2008. They find that no area was dominated by either the government or opposition, and that the Conservative backbench led frontbench questions

Symmetry violations at BABAR

Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Published under licence by IOP Publishing Ltd.2014 J. Phys.: Conf. Ser. 556 012042 (http://iopscience.iop.org/1742-6596/556/1/012042

Woodlands Health Centre, Paddock Wood A "Before and After" Study of the Workload of the General Practitioners and of the Views and Experiences of Patients

This is a report of a study of the work of a three-principal practice and of the views and experiences of some of the patients before and after the opening of a health centre which replaced the old main surgery of the practice - the branch surgery of the practice continued to function. The work of the practice was studied over the period August 1970 to Hay 1972 using an augmented form of the L Book. The centre opened in January 1971. A sample of patients was questioned just before the centre opened and then again about one and a half years later. On this latter occasion a fresh sample of patients was also questioned. In addition a survey of all main surgery attenders concerning the method of transport they used to the surgery and the origin of their journey was undertaken for two three-week periods, one just before the health centre opened and the other a year later