Auswirkungen einer bevorstehenden CT Untersuchung auf die prädiagnostische Patientenangst

Bei der Anwendung bildgebender Verfahren kann es bei betroffenen Patienten zu Angstreaktionen kommen. Patienten wurden unmittelbar vor einer geplanten CT-Untersuchung mittels State-Trait Anxiety Inventory (STAI) befragt. Zudem wurden zehn Fragen zu spezifischen Ängsten gestellt. Die statistische Analyse erfolgte mittels Student’s t-Test, linearer Regressionsanalyse und Mann-Whitney-U-Test (p<5%). 852 Untersuchungen wurden analysiert. Frauen und Patienten vor geplanter Kontrastmittelgabe zeigten signifikant höhere STAI-Werte. Patienten mit Untersuchungen der Extremitäten und Traumapatienten wiesen signifikant niedrigere STAI-Werte auf. Frauen zeigten signifikant größere Ängste als Männer in Bezug auf Strahlenexposition, Untersuchungsergebnisse, Kontrastmittelgabe und Klaustrophobie. Patienten mit Tumorerkrankungen zeigten signifikant größere Angst bezüglich der Untersuchungsergebnisse. Patientenangst ist ein Phänomen, welches auch bei der Anwendung der CT auftritt

#AUGive: Reason #9 by David Faehner

Published on Nov 9, 2017 David Faehner lists the top ten reasons to give to Andrews during Giving Tuesday on November 28, 2017.https://digitalcommons.andrews.edu/auvideo/1062/thumbnail.jp

Multiparametric MRI and Computational Modelling in the Assessment of Human Articular Cartilage Properties: A Comprehensive Approach

Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early cartilage degeneration. However, there is no consensus on which cartilage component contributes to the tissue’s qMRI signal properties. T1, T1ρ, and T2⁎ maps of cartilage samples (n=8) were generated on a clinical 3.0-T MRI system. All samples underwent histological assessment to ensure structural integrity. For cross-referencing, a discretized numerical model capturing distinct compositional and structural tissue properties, that is, fluid fraction (FF), proteoglycan (PG) and collagen (CO) content and collagen fiber orientation (CFO), was implemented. In a pixel-wise and region-specific manner (central versus peripheral region), qMRI parameter values and modelled tissue parameters were correlated and quantified in terms of Spearman’s correlation coefficient ρs. Significant correlations were found between modelled compositional parameters and T1 and T2⁎, in particular in the central region (T1: ρs≥0.7 [FF, CFO], ρs≤-0.8 [CO, PG]; T2⁎: ρs≥0.67 [FF, CFO], ρs≤-0.71 [CO, PG]). For T1ρ, correlations were considerably weaker and fewer (0.16≤ρs≤-0.15). QMRI parameters are characterized in their biophysical properties and their sensitivity and specificity profiles in a basic scientific context. Although none of these is specific towards any particular cartilage constituent, T1 and T2⁎ reflect actual tissue compositional features more closely than T1ρ

An MRI-compatible varus–valgus loading device for whole-knee joint functionality assessment based on compartmental compression: a proof-of-concept study

Objective!#!Beyond static assessment, functional techniques are increasingly applied in magnetic resonance imaging (MRI) studies. Stress MRI techniques bring together MRI and mechanical loading to study knee joint and tissue functionality, yet prototypical axial compressive loading devices are bulky and complex to operate. This study aimed to design and validate an MRI-compatible pressure-controlled varus-valgus loading device that applies loading along the joint line.!##!Methods!#!Following the device's thorough validation, we demonstrated proof of concept by subjecting a structurally intact human cadaveric knee joint to serial imaging in unloaded and loaded configurations, i.e. to varus and valgus loading at 7.5 kPa (= 73.5 N), 15 kPa (= 147.1 N), and 22.5 kPa (= 220.6 N). Following clinical standard (PDw fs) and high-resolution 3D water-selective cartilage (WATSc) sequences, we performed manual segmentations and computations of morphometric cartilage measures. We used CT and radiography (to quantify joint space widths) and histology and biomechanics (to assess tissue quality) as references.!##!Results!#!We found (sub)regional decreases in cartilage volume, thickness, and mean joint space widths reflective of areal pressurization of the medial and lateral femorotibial compartments.!##!Discussion!#!Once substantiated by larger sample sizes, varus-valgus loading may provide a powerful alternative stress MRI technique