Multifocality in Sporadic Medullary Thyroid Carcinoma:An International Multicenter Study

Background: Current surgical standard of care in sporadic medullary thyroid carcinoma (sMTC) consists of a minimum of total thyroidectomy with central neck dissection. Some have suggested thyroid lobectomy with isthmusectomy and central neck dissection for patients with sMTC, given their lower frequency of bilateral disease, although this topic has not been thoroughly studied. This study assessed the prevalence of multifocality in sMTC via a large international multi-institutional retrospective review to quantify this prevalence, including the impact of geography, to assess more accurately the risks associated with alternative surgical approaches. Methods: A retrospective chart review of sMTC patients from 11 institutions over 29 years (1983-2011) was undertaken. Data regarding focality, extent of disease, RET germline analysis plus family and clinical history for multiple endocrine neoplasia type 2 (MEN2), and demographic data were collected and analyzed. Results: Patients from four continents and seven countries were included in the sample. Data for 313 patients with documented sMTC were collected. Of these, 81.2% were confirmed with negative RET germline testing, while the remaining 18.8% demonstrated a negative family history and nomanifestations ofMEN2 syndromes other thanMTC. Bilateral disease was identified in 17/306 (5.6%) patients, while multifocal disease was noted in 50/312 (16.0%) sMTC patients. When only accounting for germline negative patients, these rates were not significantly different (5.6% and 17%, respectively). Among them, when disease was unifocal in the ipsilateral lobe and isthmus, bilateral disease was present in 6/212 (2.8%) cases. When disease was multifocal in the ipsilateral lobe or isthmus, then bilateral disease was present in 8/37 (21.6%) cases (p < 0.001). No geographic differences in focality were identified. Conclusions: The 5.6% prevalence of bilateral foci in sMTC suggests that total thyroidectomy should remain the standard of care for initial surgery, as less complete thyroid surgery may fail to address fully the primary site of disease. Whether ipsilateral tumor focality should be an independent factor determining the need for completion thyroidectomy when sMTC is diagnosed after hemithyroidectomy remains to be determined.National Cancer Institute (NCI) National Institutes of Health (NIH) Health and Human Services (HHS)Medical Research CouncilOhio State Univ, Wexner Med Ctr, Dept Otolaryngology Head & Neck Surg, Columbus, OH 43210 USAOhio State Univ, Wexner Med Ctr, Ctr Biostat, Columbus, OH 43210 USAUniv Wisconsin, Sch Med & Publ Hlth, Sect Endocrine Surg, Madison, WI USAUniv Naples Federico II, Dept Clin Med & Surg, Naples, ItalyUniv Fed Sao Paulo, Dept Med, Lab Mol & Translat Endocrinol, Div Endocrinol, Sao Paulo, BrazilUniv Siena, Sect Endocrinol & Metab, Dept Med Surg & Neurol Sci, Siena, ItalyMonash Univ, Alfred Hlth, Dept Endocrinol & Diabet, Melbourne, Vic, AustraliaPierre Oudot Hosp, Dept Endocrinol & Nephrol, Bourgoin Jallieu, FranceUniv Birmingham, Sch Clin & Expt Med, Ctr Endocrinol Diabet & Metab, Inst Biomed Res, Birmingham, W Midlands, EnglandUniv Birmingham, Inst Head & Neck Studies & Educ, Birmingham, W Midlands, EnglandRadboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, NetherlandsAlbert Schweitzer Hosp, Dept Internal Med, Dordrecht, NetherlandsUniv Athens, Evgenid Hosp, Thyroid Sect, Unit Endocrinol Diabet & Metab, Athens, GreeceInst Jules Bordet, Dept Med, Brussels, BelgiumUniv Roma La Sapienza, Dipartimento Med Interna, Rome, ItalyVeracyte Inc, 6000 Shoreline Court,Suite 300, San Francisco, CA 94080 USAOhio State Univ, Wexner Med Ctr, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USAOhio State Univ, Wexner Med Ctr, Div Nucl Med, Columbus, OH 43210 USADivision of Endocrinology, Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilNCI NIH HHS: P50 CA168505Medical Research Council: MR/J001414/1Medical Research Council: G0601811Web of Scienc

Fine Needle Aspiration and Medullary Thyroid Carcinoma: The Risk of Inadequate Preoperative Evaluation and Initial Surgery When Relying Upon FNAB Cytology Alone

Item does not contain fulltextObjectives: To evaluate the diagnostic accuracy of fine-needle aspiration biopsy (FNAB) to preoperatively diagnose medullary thyroid cancer (MTC) among multiple international centers and evaluate how the cytological diagnosis alone could impact patient management.Methods: We performed a retrospective chart review of sporadic MTC (sMTC) patients from 12 institutions over the last 29 years. FNAB cytology results were compared to final pathologic diagnoses to calculate FNAB sensitivity. To evaluate the impact of cytology sensitivity for MTC according to current practice and to avoid confounding results by local treatment protocols, changes in treatment patterns over time, and the influence of ancillary findings (e.g., serum calcitonin), therapeutic interventions based on FNAB cytology alone were projected into 1 of 4 treatment categories: total thyroidectomy (TT) and central neck dissection (CND), TT without CND, diagnostic hemithyroidectomy, or observation.Results: A total of 313 patients from 4 continents and 7 countries were included, 245 of whom underwent FNAB. FNAB cytology revealed MTC in 43.7% and possible MTC in an additional 2.4%. A total of 113 (46.1%) patients with surgical pathology revealing sMTC had FNAB findings that supported TT with CND, while 37 (15.1%) supported TT alone. In the remaining cases, diagnostic hemithyroidectomy and observation were projected in 32.7% and 6.1%, respectively.Conclusion: FNAB is an important diagnostic tool in the evaluation of thyroid nodules, but the low sensitivity of cytological evaluation alone in sMTC limits its ability to command an optimal preoperative evaluation and initial surgery in over half of affected patients