Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions. We now demonstrate that the endogenous alarmins MRP8 and MRP14 induce phagocyte hyporesponsiveness via chromatin modifications in a TLR4-dependent manner that results in enhanced survival to septic shock in mice. During sterile inflammation, polytrauma and burn trauma patients initially present with high serum concentrations of myeloid-related proteins (MRPs). Human neonatal phagocytes are primed for hyporesponsiveness by increased peripartal MRP concentrations, which was confirmed in murine neonatal endotoxinemia in wild-type and MRP14(-/-) mice. Our data therefore indicate that alarmin-triggered phagocyte tolerance represents a regulatory mechanism for the susceptibility of neonates during systemic infections and sterile inflammation

Formen und Kategorisierungen von erzwungener Migration

Paul J. Formen und Kategorisierungen von erzwungener Migration. In: Faist T, ed. Soziologie der Migration. Eine umfassende Einführung . Sozialwissenschaftliche Einführungen. Vol 2. Berlin: De Gruyter Oldenbourg; 2020: 73-96

Distributed Feedback Quantum Cascade Lasers at 3.2 µm

In this work, we present GaInAs/AlAs/AlInAs quantum cascade lasers emitting from 3.2 to 3.4 μm. Single-mode emission is obtained using buried distributed-feedback gratings fabricated using standard deep-UV contact lithography. This technique can easily be transferred to industrial production. Devices with single-mode emission down to 3.19 μm were achieved with peak power of up to 250 mW at −20 °C. A tuning range of 11 cm−1 was obtained by changing the device temperature between −30 °C and 20 °C. © 2014 Optical Society of AmericaISSN:1094-408

Beyond humanitarianism – Addressing the urban, self-settled refugees in Turkey

Stock I, Aslan M, Paul J, Volmer V, Faist T. Beyond humanitarianism – Addressing the urban, self-settled refugees in Turkey. Working Paper, COMCAD – Centre on Migration, Citizenship and Development. Vol 148/2016. Bielefeld: Bielefeld University; 2016

3β-Hydroxy-28-norolea-12,17-dien-11-one

The title compound, C29H44O2, was formed by treatment of 11-oxooleanolic acid under strong alkaline conditions. The absolute structure of the chiral molecules could not be determined reliably from the diffraction data, but is known from other triterpenes. The asymmetric unit consists of two molecules, 1 and 2. In both molecules, rings A and B show chair conformations. The other rings show mixed forms between envelope and half-chair conformations with atoms in positions 8, 15 and 21 forming the flaps in rings C, D and E, respectively. Rings D and E of molecule 2 are disordered over two orientations, with occupancies of 0.557 (4) and 0.443 (4), which differ in the direction of the flap in ring E. In the crystal, molecules 1, as well as the molecules 2, are linked by O—H...O hydrogen bonds, forming chains parallel to the b axis

Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead

Several dimethylamino-derivatives of the new compound-class 3-azabicyclo[3.2.2]nonanes were prepared. For better comparison of activity also a few analogues of bicyclo[2.2.2]octanes and 2-azabicyclo[3.2.2]nonanes were synthesized. Their activities were examined in vitro against the multiresistant K1 strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900). A couple of the newly synthesized compounds showed promising antiprotozoal activity and selectivity. The results of the biological tests of the novel compounds were compared with the activities of already synthesized compounds and of drugs in use. Structure-activity relationships were discussed