57 research outputs found
The effect of electromechanical coupling on the strain in AlGaN/GaN heterojunction field effect transistors
The strain in AlGaN/GaN heterojunction field-effect transistors (HFETs) is
examined theoretically in the context of the fully-coupled equation of state
for piezoelectric materials. Using a simple analytical model, it is shown that,
in the absence of a two-dimensional electron gas (2DEG), the out-of-plane
strain obtained without electromechanical coupling is in error by about 30% for
an Al fraction of 0.3. This result has consequences for the calculation of
quantities that depend directly on the strain tensor. These quantities include
the eigenstates and electrostatic potential in AlGaN/GaN heterostructures. It
is shown that for an HFET, the electromechanical coupling is screened by the
2DEG. Results for the electromechanical model, including the 2DEG, indicate
that the standard (decoupled) strain model is a reasonable approximation for
HFET calculataions. The analytical results are supported by a self-consistent
Schr\"odinger-Poisson calculation that includes the fully-coupled equation of
state together with the charge-balance equation.Comment: 6 figures, revte
Electromechanical coupling in free-standing AlGaN/GaN planar structures
The strain and electric fields present in free-standing AlGaN/GaN slabs are
examined theoretically within the framework of fully-coupled continuum elastic
and dielectric models. Simultaneous solutions for the electric field and strain
components are obtained by minimizing the electric enthalpy. We apply
constraints appropriate to pseudomorphic semiconductor epitaxial layers and
obtain closed-form analytic expressions that take into account the wurtzite
crystal anisotropy. It is shown that in the absence of free charges, the
calculated strain and electric fields are substantially differently from those
obtained using the standard model without electromechanical coupling. It is
also shown, however, that when a two-dimensional electron gas is present at the
AlGaN/GaN interface, a condition that is the basis for heterojunction
field-effect transistors, the electromechanical coupling is screened and the
decoupled model is once again a good approximation. Specific cases of these
calculations corresponding to transistor and superlattice structures are
discussed.Comment: revte
Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesised that Mycobacterium tuberculosis (Mtb) specifically targets negative regulatory pathways to augment immunopathology. Inhibition of signalling through the PI3K/AKT/mTORC1 pathway increased matrix metalloproteinase-1 (MMP-1) gene expression and secretion, a collagenase central to TB pathogenesis, and multiple pro-inflammatory cytokines. In patients with confirmed pulmonary TB, PI3Kδ expression was absent within granulomas. Furthermore, Mtb infection suppressed PI3Kδ gene expression in macrophages. Interestingly, inhibition of the MNK pathway, downstream of pro-inflammatory p38 and ERK MAPKs, also increased MMP-1 secretion, whilst suppressing secretion of TH1 cytokines. Cross-talk between the PI3K and MNK pathways was demonstrated at the level of eIF4E phosphorylation. Mtb globally suppressed the MMP-inhibitory pathways in macrophages, reducing levels of mRNAs encoding PI3Kδ, mTORC-1 and MNK-1 via upregulation of miRNAs. Therefore, Mtb disrupts negative regulatory pathways at multiple levels in macrophages to drive a tissue-destructive phenotype that facilitates transmission
Precision determination of band offsets in strained InGaAs/GaAs quantum wells by C-V-profiling and Schroedinger-Poisson self-consistent simulation
The results of measurements and numerical simulation of charge carrier
distribution and energy states in strained quantum wells In_xGa_{1-x}As/GaAs
(0.06 < x < 0.29) by C-V-profiling are presented. Precise values of conduction
band offsets for these pseudomorphic QWs have been obtained by means of
self-consistent solution of Schroedinger and Poisson equations and following
fitting to experimental data. For the conduction band offsets in strained
In_xGa_{1-x}As/GaAs - QWs the expression DE_C(x) = 0.814x - 0.21x^2 has been
obtained.Comment: 9 pages, 12 figures, RevTeX
Polariton and free-exciton-like photoluminescence in ZnO
An unusual photoluminescence line X has been observed in ZnO at an energy between that of the common donor-bound excitons (DBEs) and the free excitons (FEs). In the presence of a high carrier concentration, induced by a second below-band gap laser, the DBEs decrease in intensity, due to screening, and both the FEs and X increase. Thus, X has free-exciton, rather than bound-exciton, character. However, its electric-field vector lies in the plane perpendicular to the c axis, as is also found for the DBEs. The appearance of X is discussed in terms of the polariton picture.Peer reviewedPhysic
Energy levels in polarization superlattices: a comparison of continuum strain models
A theoretical model for the energy levels in polarization superlattices is
presented. The model includes the effect of strain on the local
polarization-induced electric fields and the subsequent effect on the energy
levels. Two continuum strain models are contrasted. One is the standard strain
model derived from Hooke's law that is typically used to calculate energy
levels in polarization superlattices and quantum wells. The other is a
fully-coupled strain model derived from the thermodynamic equation of state for
piezoelectric materials. The latter is more complete and applicable to strongly
piezoelectric materials where corrections to the standard model are
significant. The underlying theory has been applied to AlGaN/GaN superlattices
and quantum wells. It is found that the fully-coupled strain model yields very
different electric fields from the standard model. The calculated intersubband
transition energies are shifted by approximately 5 -- 19 meV, depending on the
structure. Thus from a device standpoint, the effect of applying the
fully-coupled model produces a very measurable shift in the peak wavelength.
This result has implications for the design of AlGaN/GaN optical switches.Comment: Revtex
Detection of rabies virus nucleoprotein-RNA in several organs outside the Central Nervous System in naturally-infected vampire bats
Rabies is a neurological disease, but the rabies virus spread to several organs outside the central nervous system (CNS). The rabies virus antigen or RNA has been identified from the salivary glands, the lungs, the kidneys, the heart and the liver. This work aimed to identify the presence of the rabies virus in non-neuronal organs from naturally-infected vampire bats and to study the rabies virus in the salivary glands of healthy vampire bats. Out of the five bats that were positive for rabies in the CNS, by fluorescent antibody test (FAT), viral isolation in N2A cells and reverse transcription - polymerase chain reaction (RT-PCR), 100% (5/5) were positive for rabies in samples of the tongue and the heart, 80% (4/5) in the kidneys, 40% (2/5) in samples of the salivary glands and the lungs, and 20% (1/5) in the liver by RT-PCR test. All the nine bats that were negative for rabies in the CNS, by FAT, viral isolation and RT-PCR were negative for rabies in the salivary glands by RT-PCR test. Possible consequences for rabies epidemiology and pathogenesis are discussed in this work
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