656 research outputs found
Reinforcement Learning via AIXI Approximation
This paper introduces a principled approach for the design of a scalable
general reinforcement learning agent. This approach is based on a direct
approximation of AIXI, a Bayesian optimality notion for general reinforcement
learning agents. Previously, it has been unclear whether the theory of AIXI
could motivate the design of practical algorithms. We answer this hitherto open
question in the affirmative, by providing the first computationally feasible
approximation to the AIXI agent. To develop our approximation, we introduce a
Monte Carlo Tree Search algorithm along with an agent-specific extension of the
Context Tree Weighting algorithm. Empirically, we present a set of encouraging
results on a number of stochastic, unknown, and partially observable domains.Comment: 8 LaTeX pages, 1 figur
Structural Color 3D Printing By Shrinking Photonic Crystals
The rings, spots and stripes found on some butterflies, Pachyrhynchus
weevils, and many chameleons are notable examples of natural organisms
employing photonic crystals to produce colorful patterns. Despite advances in
nanotechnology, we still lack the ability to print arbitrary colors and shapes
in all three dimensions at this microscopic length scale. Commercial nanoscale
3D printers based on two-photon polymerization are incapable of patterning
photonic crystal structures with the requisite ~300 nm lattice constant to
achieve photonic stopbands/ bandgaps in the visible spectrum and generate
colors. Here, we introduce a means to produce 3D-printed photonic crystals with
a 5x reduction in lattice constants (periodicity as small as 280 nm), achieving
sub-100-nm features with a full range of colors. The reliability of this
process enables us to engineer the bandstructures of woodpile photonic crystals
that match experiments, showing that observed colors can be attributed to
either slow light modes or stopbands. With these lattice structures as 3D color
volumetric elements (voxels), we printed 3D microscopic scale objects,
including the first multi-color microscopic model of the Eiffel Tower measuring
only 39-microns tall with a color pixel size of 1.45 microns. The technology to
print 3D structures in color at the microscopic scale promises the direct
patterning and integration of spectrally selective devices, such as photonic
crystal-based color filters, onto free-form optical elements and curved
surfaces
The UN Sustainable Development Goals (SDGs): Contributions from the Humanities
It is widely agreed that achieving the United Nations Sustainable Development Goals requires the insights, knowledge and comparative perspectives of Humanities disciplines. The UNESCO Hangzhou Declaration of 2013 highlighted the importance of culture as ‘an enabler and driver of sustainable development’. Yet the Humanities have so far featured relatively little in work on the SDGs
An Empirical Evaluation of Deep Learning on Highway Driving
Numerous groups have applied a variety of deep learning techniques to
computer vision problems in highway perception scenarios. In this paper, we
presented a number of empirical evaluations of recent deep learning advances.
Computer vision, combined with deep learning, has the potential to bring about
a relatively inexpensive, robust solution to autonomous driving. To prepare
deep learning for industry uptake and practical applications, neural networks
will require large data sets that represent all possible driving environments
and scenarios. We collect a large data set of highway data and apply deep
learning and computer vision algorithms to problems such as car and lane
detection. We show how existing convolutional neural networks (CNNs) can be
used to perform lane and vehicle detection while running at frame rates
required for a real-time system. Our results lend credence to the hypothesis
that deep learning holds promise for autonomous driving.Comment: Added a video for lane detectio
Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis.
Acute flaccid myelitis (AFM) has caused motor paralysis in >560 children in the United States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in AFM cases and reports of fever, respiratory, or gastrointestinal illness prior to AFM in >90% of cases suggest a role for infectious agents. Cerebrospinal fluid (CSF) from 14 AFM and 5 non-AFM patients with central nervous system (CNS) diseases in 2018 were investigated by viral-capture high-throughput sequencing (VirCapSeq-VERT system). These CSF and serum samples, as well as multiple controls, were tested for antibodies to human EVs using peptide microarrays. EV RNA was confirmed in CSF from only 1 adult AFM case and 1 non-AFM case. In contrast, antibodies to EV peptides were present in CSF of 11 of 14 AFM patients (79%), significantly higher than controls, including non-AFM patients (1/5 [20%]), children with Kawasaki disease (0/10), and adults with non-AFM CNS diseases (2/11 [18%]) (P = 0.023, 0.0001, and 0.0028, respectively). Six of 14 CSF samples (43%) and 8 of 11 sera (73%) from AFM patients were immunoreactive to an EV-D68-specific peptide, whereas the three control groups were not immunoreactive in either CSF (0/5, 0/10, and 0/11; P = 0.008, 0.0003, and 0.035, respectively) or sera (0/2, 0/8, and 0/5; P = 0.139, 0.002, and 0.009, respectively).IMPORTANCE The presence in cerebrospinal fluid of antibodies to EV peptides at higher levels than non-AFM controls supports the plausibility of a link between EV infection and AFM that warrants further investigation and has the potential to lead to strategies for diagnosis and prevention of disease
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