38 research outputs found
Recursive quantum repeater networks
Internet-scale quantum repeater networks will be heterogeneous in physical
technology, repeater functionality, and management. The classical control
necessary to use the network will therefore face similar issues as Internet
data transmission. Many scalability and management problems that arose during
the development of the Internet might have been solved in a more uniform
fashion, improving flexibility and reducing redundant engineering effort.
Quantum repeater network development is currently at the stage where we risk
similar duplication when separate systems are combined. We propose a unifying
framework that can be used with all existing repeater designs. We introduce the
notion of a Quantum Recursive Network Architecture, developed from the emerging
classical concept of 'recursive networks', extending recursive mechanisms from
a focus on data forwarding to a more general distributed computing request
framework. Recursion abstracts independent transit networks as single relay
nodes, unifies software layering, and virtualizes the addresses of resources to
improve information hiding and resource management. Our architecture is useful
for building arbitrary distributed states, including fundamental distributed
states such as Bell pairs and GHZ, W, and cluster states.Comment: 14 page
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome\u27s functional composition in healthy metabolic state and the most severe states of obesity and type 2 diabetes within the MetaCardis cohort. We focused on the role of B vitamins and B7/B8 biotin for regulation of host metabolic state, as these vitamins influence both microbial function and host metabolism and inflammation. Design We performed metagenomic analyses in 1545 subjects from the MetaCardis cohorts and different murine experiments, including germ-free and antibiotic treated animals, faecal microbiota transfer, bariatric surgery and supplementation with biotin and prebiotics in mice. Results Severe obesity is associated with an absolute deficiency in bacterial biotin producers and transporters, whose abundances correlate with host metabolic and inflammatory phenotypes. We found suboptimal circulating biotin levels in severe obesity and altered expression of biotin-associated genes in human adipose tissue. In mice, the absence or depletion of gut microbiota by antibiotics confirmed the microbial contribution to host biotin levels. Bariatric surgery, which improves metabolism and inflammation, associates with increased bacterial biotin producers and improved host systemic biotin in humans and mice. Finally, supplementing high-fat diet-fed mice with fructo-oligosaccharides and biotin improves not only the microbiome diversity, but also the potential of bacterial production of biotin and B vitamins, while limiting weight gain and glycaemic deterioration. Conclusion Strategies combining biotin and prebiotic supplementation could help prevent the deterioration of metabolic states in severe obesity
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism
Native Digital Processing for Optical Networking
Abstract—The Optical Turing Machine (OTM) is an approach to digital optical processing that supports computation in the same format used for high-speed transmission. This paper identifies the key capabilities required to support native digital optical processing for typical in-network functions including forwarding, security, and filtering. Current analog and binary digital approaches – including optical transistors – are considered and shown insufficient for optical networks. The requirements for a single encoding are presented, as are the capabilities required for network computation