Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate

Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue- based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown. In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin receptor type AT1 in the prostate at the protein and mRNA level. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 497–503

Challenges related to the production of "artificial meat"

The article discusses number of issues related to the production of the socalled „artificial meat”, from biological and ethical problems and challenges that biotechnology has to face when changing the scale of production from laboratory to small or large industrial scale. Issues related to environmental protection in the context of climate change, the use of electrical energy, water resources and CO2 production were also discussed. The balance of profits and losses made so far does not give grounds for full admiration for the idea of artificial meat, the more so as consumers and nutrition specialists also have a lot of reservations in accepting new food. Nevertheless, visions of politicians, including European Parliament, are ahead of time and lead to the legal regulations of the artificial meat

Can artificial meat save the humankind?

For nearly a decade, the public has been informed about new, innovative ideas for producing meat in a test tube. “Artificial meat” if you prefer, “laboratory meat” or “in vitro meat”, appears in these messages as an alternative to beef, mutton, pork, poultry and even aquaculture. An ethical, safe, and ecological alternative, and the monstrous costs of the first portions of such artificial meat are explained by the assurance that the prototype must always be expensive, and as production and the approval of the technology increases, prices will become more affordable for the average consumer. In this article, which is a follow-up to our previous text (ŻW, 2020, 95, 74-80), we present the logic of a start-up business interested in the technology of producing artificial meat and its recent noticeable drift towards meat substitutes of plant origin rather than in vitro cultures. In addition, we discuss selected aspects related to the safety of both the consumer and the natural environment. The article concludes with a statement made by French scientist at INRAE Jean-Louis Peyraud in 2017: ”A world without animal husbandry is just a utopia in the short, medium, and long term. It is high time we went back to a more realistic, evidence-based approach.

Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate

Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue- based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown. In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin receptor type AT1 in the prostate at the protein and mRNA level. (<i>Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 497–503</i>