The lectin level and the effect of abscisic acid on hemagglutinating activity during rye germination

As we have previously found, the embryo is the only source of lectin in the mature, dry rye seed. During early germination the lectin activity decreased and most of it was found in the coleoptile. Leaves were found to contain only a trace amount of this protein. A 5-7 fold increase in the amount of lectin was found in grains which had imbibed for 6­12 hours in the presence of 10-5M and 10-4M ABA. At an ABA concentration of 10-4M, about 6 µg of lectin per germ was found even in grains which had been germinating for 5 days. The immunological properties and molecular masses of both RGA and RGA­like lectin accumulated in the presence of ABA were found to be identical

Experience with biosimilar infliximab (CT-P13) in paediatric patients with inflammatory bowel diseases

Infliximab was the first monoclonal antibody used in the treatment of inflammatory bowel disease (IBD). Over several years, this antitumour necrosis factor (TNF) treatment proved its efficacy in both induction and maintenance therapy. In many cases this biological treatment stopped the progression of the disease, probably also decreasing morbidity and hospitalization rates, and improving patients’ comfort. When the patent on infliximab started to expire, the first biosimilar of a monoclonal antibody was introduced onto the pharmacological market. Biosimilar infliximab was studied in rheumatology and proved a high similarity to the reference drug. Based on extrapolation, biosimilars were approved to treat adult and paediatric IBD patients. Biosimilar infliximab, mainly because of its lower cost, has started to be in common use in Europe. The first studies have shown a similar efficacy and safety profile in comparison with reference drug. Biosimilar infliximab is raising hopes for improving the availability of this effective treatment

Usefulness of Colon Assessment by Magnetic Resonance Enterography in Pediatric Patients with Inflammatory Bowel Disease—Retrospective Case Series

Background: Magnetic resonance enterography (MRE) is an excellent way to study the small bowels. During such an examination, the colon is also seen within the field of study. The aim of this study was to evaluate the effectiveness of MRE in detecting characteristics of active inflammatory bowel disease (IBD) in the colon, in comparison to different features seen in colonoscopies. Methods: This retrospective study was conducted with 41 children. Features of active inflammation we considered were wall thickening; contrast enhancement; incorrect signal in the DWI sequence in the MRE; and presence of ulceration, erosion, erythema, spontaneous bleeding and a decrease of the vascular pattern seen in colonoscopy. The colon was divided into six segments: caecum, ascending, transverse, descending, sigmoid and rectum. Results: The sensitivity of MRE was, on average, 50–75%, and as high as 92–100%, depending on the segment. The most important feature for which there was the most dependencies was ulceration. In the analysis of intestinal wall thickness, the AUC value >0.8 was detected as ulceration (segments: cecum, ascending, descending colon, sigmoid), spontaneous bleeding (ascending colon and sigmoid) and decreased vascular pattern (ascending, transverse, descending colon). Conclusions: Evaluation of qualitative structural changes in MRE distinguishes patients with inflammation in colonoscopy from patients without lesions, with high diagnostic accuracy, albeit higher specificity than sensitivity

Planning nursing care for a patient diagnosed with testicular cancer by using International Classification for Nursing Practice (ICNP®)

Testicular cancer is the most common malignancy in young men and its prevalence is increasing all overthe world. The diagnosis of such a life-threatening disease at a relatively young age may have a considerabledevastating impact on numerous spheres of everyday functioning. Although testicular cancertreatment is highly effective, in some cases only symptomatic treatment is possible, an integral partof which is specialist nursing care. This study aimed to present the possibility of using the terminologyof the International Classification for Nursing Practice (ICNP®) in planning nursing care for a hospicepatient suffering from advanced testicular cancer. An analysis of medical records allowed for developinga patient’s case and then formulating a plan of nursing care considering diagnoses concerningbiopsychosocial functioning and nursing intervention. Moreover, the study highlights typical problemsof patients in the period of dying as well as the role of a nurse in hospice care

Souvenirs de la Flandre-wallonne : recherches historiques et choix de documents relatifs à Douai et à la province / publiés par une réunion d'amateurs et d'archéologues

18711871 (T11)-1871.Appartient à l’ensemble documentaire : NordPdeC1Appartient à l’ensemble documentaire : RfnEns0Appartient à l’ensemble documentaire : RfnEuro1Appartient à l’ensemble documentaire : RfnCoop

Państwo i Społeczeństwo nr 4, 2017 : Medycyna i zdrowie publiczne

ZE WSTĘPU: Niniejszy numer „Państwa i Społeczeństwa”, poświęcony medycynie i zdrowiu publicznemu, zawiera cztery prace oryginalne, pięć poglądowych i jeden opis przypadku. Istotne miejsce zajmują w nim prace przedstawione podczas XVII Konferencji Naukowej „Państwo, gospodarka, społeczeństwo” w Krakowskiej Akademii im. Andrzeja Frycza Modrzewskiego w czerwcu 2017 r