Erythema dyschromicum perstans (ashy dermatosis) during the treatment with infliximab in a child with Crohn disease

Introduction . Erythema dyschromicum perstans (EDP) or ashy dermatosis is a rare, benign acquired disease characterized by macular hyperpigmentations. The cause of EDP is unclear although some drugs, toxic agents and internal disorders have been associated with this dermatosis. Objective . Presentation of the first case of the association between EDP and Crohn disease treated with infliximab. Case report . We present a case of a 15-year-old boy with Crohn disease who was treated with infliximab. During the treatment asymptomatic, hyperpigmented macules on the trunk were observed. Based on clinical and histopathological features the diagnosis of erythema dyschromicum perstans was established. Conclusions . Erythema dyschromicum perstans may be associated with Crohn disease and infliximab

Primary Ewing Sarcoma of the Thyroid—Eight Cases in a Decade: A Case Report and Literature Review

Sarcomas represent less than 1% of all malignant tumors found in the thyroid. Of these, primary extraosseoussarcoma has been reported only a few times in the past decade. We present the case of a 34-year-old male who had a fast-growing hard mass in the lower left neck. FNA was inconclusive. Core needle biopsy revealed the diagnosis of an Ewing sarcoma/primitive neuroectodermal tumor. Mutation of EWSR1 was confirmed using the FISH method. Following treatment by neoadjuvant chemotherapy, we observed clinical, radiological, and finally histopathological remission. This was followed by a left-sided isthmolobectomy with unilateral cervical lymph node dissection by lateral lymphadenectomy, which revealed no residual disease. Posttreatment radiotherapy was administered but discontinued upon the patient’s request. After 18 months of observation, the patient had no recurrence or metastasis and required l-thyroxine supplementation. We discuss our case using a comparative literature review to the few other known case reports

Security theory and practice: The Total Defence 21st century.COM – building a resilient society

Introduction: "When we started working on the issue entitled “The Total Defence 21st century. COM – building a resilient society”, we did not know then how topical this issue would become. We were aware of its importance, especially since 2014, which was the beginning of the Russian aggression against Ukraine. However, we did not think that the need to build an effective concept of total/comprehensive defence, and then its implementation, would become so pressing in February 2022. Two of the three general regularities in the history of international relations have also become extremely topical. We are talking about the clash between imperial and polyarchic tendencies, and nations’ desire to express their independence and identity, and as a result, to have their own state. It can be assumed that in order to achieve this goal, as well as for small and medium-sized states to be able to defend themselves against the forces of empires and effectively deter them, they must use the concept of total/comprehensive defence, in its improved, 21st century version."(...