3,282 research outputs found

    Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials

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    Objective To compare antimüllerian hormone (AMH) and antral follicle count (AFC) as predictors of ovarian response to controlled ovarian stimulation at individual fertility clinics. Design Retrospective analysis of individual study center data in two multicenter trials. Centers that provided >10 patients were included in the analysis. Setting A total of 19 (n = 519 patients) and 18 study centers (n = 686 patients) participating in a long GnRH agonist trial (MERIT) and a GnRH antagonist trial (MEGASET), respectively. Patient(s) Infertile women of good prognosis. Intervention(s) Long GnRH agonist or GnRH antagonist cycles. Main Outcome Measure(s) Correlation between AMH and AFC, and oocyte yield by each study center for each trial. Results(s) Antimüllerian hormone was more strongly correlated with oocyte yield than AFC: r = 0.56 vs. r = 0.28 in the GnRH agonist cohort, and r = 0.55 vs. r = 0.33 in the GnRH antagonist cohort. The correlation was numerically higher for AMH than for AFC at a significantly higher proportion of study centers: 17 (89%) and 15 (83%) centers in the long GnRH agonist and GnRH antagonist trial, respectively. Assessment of the relative capacity of AMH and AFC for predicting oocyte yield demonstrated that AMH dominated the model: AMH, R2 = 0.29 and 0.23; AFC: R2 = 0.07 and 0.07; AMH + AFC: R2 = 0.30 and 0.23 for long GnRH agonist and GnRH antagonist trials, respectively. Conclusions(s) Antimüllerian hormone was a stronger predictor of ovarian response to gonadotropin therapy than AFC at the study center level in both randomized trials utilizing GnRH agonist and GnRH antagonist protocols. Antral follicle count provided no added predictive value beyond AMH.</p

    Attitude Change of Spinal Cord Injured Males and Their Marital Partner Involved in a Sexual Therapy Program

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    The purpose of this investigation was to study the changes in attitude of a group of spinal cord injured males and their marital partners after a sexual therapy treatment program. The investigation utilized a two-group design. The experimental group consisted of five couples who had sought treatment of difficulties in the sexual aspect of their relationship and had indicated some degree of inadequacy in this area on the part of one or both partners. The control group consisted of five similar couples who agreed to wait or did not feel ready for the treatment program. In both groups the male partner had suffered a spinal cord lesion and the effects of the injury presented problems in the sexual sphere of the relationship with their partner

    Politics and Professionalism: Women Historians in the 1980s

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    Those of you who think keynote speakers are chosen for their knowledge, wisdom, or fame should be disabused of those beliefs, at least in my case. I was asked to give this talk because I ventured an opinion about the subject that should be addressed in this year\u27s keynote address during a meeting of the program committee over a year ago. At that time the American Historical Association\u27s Committee on Women Historians (CWH) was preparing its update of the 1971 Rose Report on the Status of Women in the Historical Profession and the figures gave little reason for optimism either about what we had gained in the decade of the 1970s or about what lay ahead in the contracting economy of the 1980s. In addition, I was then chairing the Committee on the Status of Women at the University of North Carolina at Chapel Hill, and I was painfully aware of the stubborn resistance of departments and deans to the recognition, promotion, and tenuring of women faculty members. Over a nd over again I watched the power of shared male biases perpetuate inequality even as federal affirmative action plans cleaned up procedures and forced at least formal accountability to good faith efforts. So, when the program committee turned to the question of the keynote , I urged that we think in terms of subject matter, not personalities, and I said (probably in an impassioned voice) that we needed someone to address the question of political action by women such as us in the face of economic retrenchment and cultural backlash. My outburst produced thoughtful silence , then approbation, then the assignment. I agreed to consider doing it and eventually decided I could

    Third Grade Library Power!

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    The process of curriculum design for a third grade information literacy skills unit was studied. Studies supporting the connection between a quality school library program and increased student achievement were examined for positive characteristics to be implemented into a third grade library program. State standards in reading, technology, and information skills were analyzed for integration into the design. The result is a third grade information literacy skills curriculum design for implementation into a library program. Implications for future third grade library curriculum improvements are discussed

    Flexibility as an Instrument in Digital Rights Management

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    We consider the optimal design of flexible use in a digital-rights-management policy. The basic model considers a single distributor of digital goods and a continuum of consumers. Each consumer can acquire the digital good either as a licensed product or an unlicensed copy. The availability of (or access to) unlicensed copies is increasing both in the number of licensed copies and in the flexibility accorded to licensed copies. We thus analyze the optimal design of flexibility in the presence of unlicensed distribution channels (the "greynet"). We augment the basic model by introducing a “secure platform” that is required to use the digital good. We compare the optimal design of flexibility in the presence of a platform to the one without a platform. Finally, we analyze the equilibrium provision when platform and content are complimentary goods but are distributed and priced by different sellers.Digital Rights Management, Platform, Flexibility, Piracy

    Pricing under the Threat of Piracy: Flexibility and Platforms for Digital Goods

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    We consider the optimal design of flexible use in a digital-rights-management policy for a digital good subject to piracy. Consumers can acquire the digital good either as a licensed product or as an unlicensed copy. The ease of access to unlicensed copies is increasing in the flexibility accorded to licensed copies. The content provider has to trade off consumers' valuation of a licensed copy against the sales lost to piracy. We enrich the basic model by introducing a "secure platform" that is required to use the digital good. We show that the platform allows for the socially optimal provision of flexibility for the digital good but only if both are sold by an integrated firm.Digital goods, Digital rights management, Platform, Flexibility, Piracy
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