Sex on TV 2

Part of a series that examines the nature and extent of sexual messages conveyed on TV. Tracks changes that occur over time in the treatment of sexual topics, including references to possible risks or responsibilities. Based on a 1999-2000 program sample

On Galactic density modeling in the presence of dust extinction

Inferences about the spatial density or phase-space structure of stellar populations in the Milky Way require a precise determination of the effective survey volume. The volume observed by surveys such as Gaia or near-infrared spectroscopic surveys, which have good coverage of the Galactic mid-plane region, is highly complex because of the abundant small-scale structure in the three-dimensional interstellar dust extinction. We introduce a novel framework for analyzing the importance of small-scale structure in the extinction. This formalism demonstrates that the spatially-complex effect of extinction on the selection function of a pencil-beam or contiguous sky survey is equivalent to a low-pass filtering of the extinction-affected selection function with the smooth density field. We find that the angular resolution of current 3D extinction maps is sufficient for analyzing Gaia sub-samples of millions of stars. However, the current distance resolution is inadequate and needs to be improved by an order of magnitude, especially in the inner Galaxy. We also present a practical and efficient method for properly taking the effect of extinction into account in analyses of Galactic structure through an effective selection function. We illustrate its use with the selection function of red-clump stars in APOGEE using and comparing a variety of current 3D extinction maps.Comment: Code available at https://github.com/jobovy/mwdust and at https://github.com/jobovy/apogee-map

Sex on TV: Content and Context

Part of a series that examines the nature and extent of sexual messages conveyed on American television. Focuses on references to contraception, safer sex, and waiting to have sex. Based on a sample of 1997-1998 programs

Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses.

Nanoparticles have attracted considerable interest as cancer vaccine delivery vehicles for inducing sufficient CD8+ T cell-mediated immune responses to overcome the low immunogenicity of the tumor microenvironment. Our studies described here are the first to examine the effects of clinically-tested human cancer-testis (CT) peptide epitopes within a synthetic nanoparticle. Specifically, we focused on two significant clinical CT targets, the HLA-A2 restricted epitopes of NY-ESO-1 and MAGE-A3, using a viral-mimetic packaging strategy. Our data shows that simultaneous delivery of a NY-ESO-1 epitope (SLLMWITQV) and CpG using the E2 subunit assembly of pyruvate dehydrogenase (E2 nanoparticle), resulted in a 25-fold increase in specific IFN-γ secretion in HLA-A2 transgenic mice. This translated to a 15-fold increase in lytic activity toward target cancer cells expressing the antigen. Immunization with a MAGE-A3 epitope (FLWGPRALV) delivered with CpG in E2 nanoparticles yielded an increase in specific IFN-γ secretion and cell lysis by 6-fold and 9-fold, respectively. Furthermore, combined delivery of NY-ESO-1 and MAGE-A3 antigens in E2 nanoparticles yielded an additive effect that increased lytic activity towards cells bearing NY-ESO-1+ and MAGE-A3+. Our investigations demonstrate that formulation of CT antigens within a nanoparticle can significantly enhance antigen-specific cell-mediated responses, and the combination of the two antigens in a vaccine can preserve the increased individual responses that are observed for each antigen alone

The stellar population structure of the Galactic disk

The spatial structure of stellar populations with different chemical abundances in the Milky Way contains a wealth of information on Galactic evolution over cosmic time. We use data on 14,699 red-clump stars from the APOGEE survey, covering 4 kpc <~ R <~ 15 kpc, to determine the structure of mono-abundance populations (MAPs)---stars in narrow bins in [a/Fe] and [Fe/H]---accounting for the complex effects of the APOGEE selection function and the spatially-variable dust obscuration. We determine that all MAPs with enhanced [a/Fe] are centrally concentrated and are well-described as exponentials with a scale length of 2.2+/-0.2 kpc over the whole radial range of the disk. We discover that the surface-density profiles of low-[a/Fe] MAPs are complex: they do not monotonically decrease outwards, but rather display a peak radius ranging from ~5 kpc to ~13 kpc at low [Fe/H]. The extensive radial coverage of the data allows us to measure radial trends in the thickness of each MAP. While high-[a/Fe] MAPs have constant scale heights, low-[a/Fe] MAPs flare. We confirm, now with high-precision abundances, previous results that each MAP contains only a single vertical scale height and that low-[Fe/H], low-[a/Fe] and high-[Fe/H], high-[a/Fe] MAPs have intermediate (h_Z~300 to 600 pc) scale heights that smoothly bridge the traditional thin- and thick-disk divide. That the high-[a/Fe], thick disk components do not flare is strong evidence against their thickness being caused by radial migration. The correspondence between the radial structure and chemical-enrichment age of stellar populations is clear confirmation of the inside-out growth of galactic disks. The details of these relations will constrain the variety of physical conditions under which stars form throughout the MW disk.Comment: Code available at https://github.com/jobovy/apogee-map

Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.

ObjectiveBenefits of social support (SS) during cancer survivorship are complex. This study examines change in SS over time in cervical cancer (CXCA) survivors who have completed definitive treatment and how changing SS impacts quality of life (QOL) and T-helper type 2 (Th2) cytokines.MethodsWe conducted a randomized trial in 204 CXCA survivors to test if psychosocial telephone counseling (PTC) could improve QOL compared to usual care (UC). Although PTC did not target SS, data were collected at baseline, 4 and 9 months post-enrollment using the Medical Outcomes Survey Social Support scale. Biospecimens were collected to investigate associations with patient-reported outcomes. Data were analyzed using multivariate linear models and stepwise regression.ResultsParticipants' mean age was 43. PTC participants experienced increasing SS compared to UC at 4 months (PTC-UC = 5.1; p = 0.055) and 9 months (PTC-UC = 6.0; p = 0.046). Higher baseline SS and increasing SS were independently associated with improved QOL at 4 and 9 months after adjusting for patient characteristics (p &lt; 0.05). Differences between study arms were not statistically significant. Improvements in QOL at 4 months were observed with increases in emotional/informational and tangible SS. Increasing SS predicted significant longitudinal decreases in IL-4 and IL-13 at 4 months that were larger in the PTC arm (interactions p = 0.041 and p = 0.057, respectively).ConclusionImproved SS was significantly associated with improved QOL independent of patient characteristics and study arm. Decreasing Th2 cytokines with increasing SS and QOL are consistent with a biobehavioral paradigm in which modulation of the chronic stress response is associated with shifts in immune stance

Investigating the feedbacks between CO2, vegetation and the AMOC in a coupled climate model

The Atlantic Meridional Overturning Circulation (AMOC) is an important component of the climate system, however its sensitivity to the terrestrial biosphere has been largely overlooked. Here the HadCM3 coupled climate model is run for millennial timescales to investigate the feedbacks between vegetation and the AMOC at increasing CO2. The impact of agricultural conversion (termed land-use change; LUC) and the role of the simulated 'background' vegetation (termed land cover change; LCC) are investigated. LUC cools climate in regions of high crop fraction due to increased albedo. LCC is shown to evolve at higher CO2, with a northward migration of the tree line in the Northern Hemisphere and dieback of the Amazon. This generally acts to enhance the impact of climate change primarily due to albedo changes. Density in the Greenland-Iceland-Norwegian (GIN) Seas is crucial in driving the AMOC. Increasing CO2 decreases regional sea surface density, reducing convection and weakening the AMOC. The inclusion of LCC is shown to be responsible for a significant proportion of this weakening; reflecting the amplification effect it has on climate change. This acts to decrease the surface density in the GIN Seas. At elevated CO2 (1400 ppm) the inclusion of dynamic vegetation is shown to drive a reduction in AMOC strength from 6 to 20%. Despite the cooling effect of LUC, the impact on the AMOC is shown to be small reflecting minimal impact it has on GIN Sea density. These results indicate the importance of including dynamic vegetation in future AMOC studies using HadCM3, but LUC may be insignificant. In the context of other climate models however, the importance of vegetation is likely to be overshadowed by other systemic model biases.Peer reviewe

Perceived barriers and opportunities to improve working conditions and staff retention in Emergency Departments:a qualitative study

Background:Staff retention in Emergency Medicine (EM) is at crisis level and could be attributed in some part to adverse working conditions. This study aimed to better understand current concerns relating to working conditions and working practices in Emergency Departments (EDs).Methods:A qualitative approach was taken, using focus groups with ED staff (doctors, nurses, advanced care practitioners) of all grades, seniority and professional backgrounds from across the UK. Snowball recruitment was undertaken using social media and Royal College of Emergency Medicine communication channels. Focus groups were conducted online and organised by profession. A semi structured topic guide was used to explore difficulties in the work environment, impact of these difficulties, barriers and priorities for change. Data were analysed using a directive content analysis to identify common themes.Results:Of the 116 clinical staff who completed the eligibility and consent forms, 46 met criteria and consented, of those, 33 participants took part. Participants were predominantly White British (85%), female (73%) and doctors (61%). Four key themes were generated: ‘culture of blame and negativity’, ‘Untenable working environments’, ‘compromised leadership’ and ‘striving for support’. Data pertaining to barriers and opportunities for change were identified as sub-themes. In particular, strong leadership emerged as a key driver of change across all aspects of working practices.Conclusion:This study identified four key themes related to workplace concerns and their associated barriers and opportunities for change. Culture, working environment and need for support echoed current narratives across healthcare settings. Leadership emerged more prominently than in prior studies as both a barrier and opportunity for wellbeing and retention in the EM workplace. Further work is needed to develop leadership skills early on in clinical training, provide protected time and opportunity to refine leadership skills and a clear pathway to address higher levels of management

Psychological predictors of health anxiety and pain in ambulatory presentations in a hospital emergency department

Abstract Background: Health anxiety in attendees of out-patient medical clinics is well established; however, there has been a lack of research into health anxiety within emergency settings. Aims: This study explored the prevalence of health anxiety in ambulatory presentations in a tertiary emergency department (ED) as well as the factors associated with pain and health anxiety in this setting. Method: A cross-sectional questionnaire design was used to gather data from adult ED ambulatory attendees across a 4-day sampling period to assess psychological and physical health variables. Number of attendances to ED over the previous 12 months was accessed through healthcare records. Results: Of the final sample (n = 106), 77%were white British, 54%were male, and 14%presented with severe health anxiety as measured by the Short Health Anxiety Inventory (≥18). Participants with pre-existing health conditions had significantly higher levels of health anxiety (M = 12.36, SE = 1.59) compared with those without (M = 7.79, SE = 0.66). Stepwise multiple regression analyses identified anxiety sensitivity and pain catastrophizing as significant independent predictors of health anxiety, explaining 51%of the variance in health anxiety. Pain catastrophizing was also a significant independent predictor of pain level, accounting for 20%of the variance. Conclusion: This study provides insight into the prevalence of health anxiety in ED ambulatory presentations and key psychological predictors of health anxiety and pain. This has implications for treatment in an ED setting whereby patients may benefit from referral to medical psychology or mental health services.</p

Psychologically Informed Practice and Policy (PIPP) Project:Key Recommendations for Retention and Workforce Wellbeing in Emergency Care

The PIPP project is a UKRI funded collaborative study between University of Bath and the Royal College of Emergency Medicine. The PiPP Project investigated current workplace concerns, barrier to change and opportunities for development and growth. This document details specific evidence-based recommendations relating to four key areas identified within the PIPP project as prioritised targets in emergency care workforce development: ‘an environment to thrive in’, ‘cultivating a better culture’, ‘a tailored pathway of care’ and ‘enhanced leadership’. The recommendations are based on new empirical data and supported by existing guidelines and research