TransNet: Transparent Object Manipulation Through Category-Level Pose Estimation

Transparent objects present multiple distinct challenges to visual perception systems. First, their lack of distinguishing visual features makes transparent objects harder to detect and localize than opaque objects. Even humans find certain transparent surfaces with little specular reflection or refraction, like glass doors, difficult to perceive. A second challenge is that depth sensors typically used for opaque object perception cannot obtain accurate depth measurements on transparent surfaces due to their unique reflective properties. Stemming from these challenges, we observe that transparent object instances within the same category, such as cups, look more similar to each other than to ordinary opaque objects of that same category. Given this observation, the present paper explores the possibility of category-level transparent object pose estimation rather than instance-level pose estimation. We propose \textit{\textbf{TransNet}}, a two-stage pipeline that estimates category-level transparent object pose using localized depth completion and surface normal estimation. TransNet is evaluated in terms of pose estimation accuracy on a large-scale transparent object dataset and compared to a state-of-the-art category-level pose estimation approach. Results from this comparison demonstrate that TransNet achieves improved pose estimation accuracy on transparent objects. Moreover, we use TransNet to build an autonomous transparent object manipulation system for robotic pick-and-place and pouring tasks

Lamb waves manipulation by piezoelectric metasurface with tunable diffraction orders

In this paper, a piezoelectric metasurface is proposed to manipulate the anti-symmetric mode Lamb wave by altering the diffraction order. The metasurface attached to a host plate is symmetrically arranged by out-of-plane polarized piezoelectric patches connected with synthetic inductance circuits. Without changing the physical configuration, the transmitted phase of the anti-symmetric mode Lamb wave can be shifted arbitrarily in 0 ∼ 2π range by the metasurface. Furthermore, the relationship between the phase gradient and diffraction order is investigated, and different orders of diffraction waves can be obtained by adjusting the shunting inductance circuits. The symmetric transmission and asymmetric transmission from a couple of axis symmetric incident waves can be realized by utilizing +1st-order and −1st-order diffraction. Moreover, omnidirectional wave reflection and wave trapping in channelized waveguides can also be realized by utilizing the 0th-order diffraction. The results indicate that the proposed piezoelectric metasurface has great potentials in manipulating guided waves with a large incident angle and isolating wave propagation

Therapeutic targeting of replicative immortality

One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic resistance. Innate cellular mechanisms have evolved to regulate replicative potential as a hedge against malignant progression. When activated in the absence of normal terminal differentiation cues, these mechanisms can result in a state of persistent cytostasis. This state, termed “senescence,” can be triggered by intrinsic cellular processes such as telomere dysfunction and oncogene expression, and by exogenous factors such as DNA damaging agents or oxidative environments. Despite differences in upstream signaling, senescence often involves convergent interdependent activation of tumor suppressors p53 and p16/pRB, but can be induced, albeit with reduced sensitivity, when these suppressors are compromised. Doses of conventional genotoxic drugs required to achieve cancer cell senescence are often much lower than doses required to achieve outright cell death. Additional therapies, such as those targeting cyclin dependent kinases or components of the PI3K signaling pathway, may induce senescence specifically in cancer cells by circumventing defects in tumor suppressor pathways or exploiting cancer cells’ heightened requirements for telomerase. Such treatments sufficient to induce cancer cell senescence could provide increased patient survival with fewer and less severe side effects than conventional cytotoxic regimens. This positive aspect is countered by important caveats regarding senescence reversibility, genomic instability, and paracrine effects that may increase heterogeneity and adaptive resistance of surviving cancer cells. Nevertheless, agents that effectively disrupt replicative immortality will likely be valuable components of new combinatorial approaches to cancer therapy

Study on tinnitus-related electroencephalogram microstates in patients with vestibular schwannomas

Tinnitus is closely associated with cognition functioning. In order to clarify the central reorganization of tinnitus in patients with vestibular schwannoma (VS), this study explored the aberrant dynamics of electroencephalogram (EEG) microstates and their correlations with tinnitus features in VS patients. Clinical and EEG data were collected from 98 VS patients, including 76 with tinnitus and 22 without tinnitus. Microstates were clustered into four categories. Our EEG microstate analysis revealed that VS patients with tinnitus exhibited an increased frequency of microstate C compared to those without tinnitus. Furthermore, correlation analysis demonstrated that the Tinnitus Handicap Inventory (THI) score was negatively associated with the duration of microstate A and positively associated with the frequency of microstate C. These findings suggest that the time series and syntax characteristics of EEG microstates differ significantly between VS patients with and without tinnitus, potentially reflecting abnormal allocation of neural resources and transition of functional brain activity. Our results provide a foundation for developing diverse treatments for tinnitus in VS patients

The auxin influx carrier, OsAUX3, regulates rice root development and responses to aluminium stress

In rice, there are five members of the auxin carrier AUXIN1/LIKE AUX1 family; however, the biological functions of the other four members besides OsAUX1 remain unknown. Here, by using CRISPR/Cas9, we constructed two independent OsAUX3 knock‐down lines, osaux3‐1 and osaux3‐2, in wild‐type rice, Hwayoung (WT/HY) and Dongjin (WT/DJ). osaux3‐1 and osaux3‐2 have shorter primary roots (PRs), decreased lateral root (LR) density, and longer root hairs (RHs) compared with their WT. OsAUX3 expression in PRs, LRs, and RHs further supports that OsAUX3 plays a critical role in the regulation of root development. OsAUX3 locates at the plasma membrane and functions as an auxin influx carrier affecting acropetal auxin transport. OsAUX3 is up‐regulated in the root apex under aluminium (Al) stress, and osaux3‐2 is insensitive to Al treatments. Furthermore, 1‐naphthylacetic acid accented the sensitivity of WT/DJ and osaux3‐2 to respond to Al stress. Auxin concentrations, Al contents, and Al‐induced reactive oxygen species‐mediated damage in osaux3‐2 under Al stress are lower than in WT, indicating that OsAUX3 is involved in Al‐induced inhibition of root growth. This study uncovers a novel pathway alleviating Al‐induced oxidative damage by inhibition of acropetal auxin transport and provides a new option for engineering Al‐tolerant rice species

The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation

It is widely known that ischemic stroke is the prominent cause of death and disability. To date, neuroinflammation following ischemic stroke represents a complex event, which is an essential process and affects the prognosis of both experimental stroke animals and stroke patients. Intense neuroinflammation occurring during the acute phase of stroke contributes to neuronal injury, BBB breakdown, and worse neurological outcomes. Inhibition of neuroinflammation may be a promising target in the development of new therapeutic strategies. RhoA is a small GTPase protein that activates a downstream effector, ROCK. The up-regulation of RhoA/ROCK pathway possesses important roles in promoting the neuroinflammation and mediating brain injury. In addition, nuclear factor-kappa B (NF-κB) is another vital regulator of ischemic stroke-induced neuroinflammation through regulating the functions of microglial cells and astrocytes. After stroke onset, the microglial cells and astrocytes are activated and undergo the morphological and functional changes, thereby deeply participate in a complicated neuroinflammation cascade. In this review, we focused on the relationship among RhoA/ROCK pathway, NF-κB and glial cells in the neuroinflammation following ischemic stroke to reveal new strategies for preventing the intense neuroinflammation

Blind leads Blind: A Zero-Knowledge Attack on Federated Learning

Attacks on Federated Learning (FL) can severely reduce the quality of the generated models and limit the usefulness of this emerging learning paradigm that enables on-premise decentralized learning. There have been various untargeted attacks on FL, but they are not widely applicable as they i) assume that the attacker knows every update of benign clients, which is indeed sent in encrypted form to the central server, or ii) assume that the attacker has a large dataset and sufficient resources to locally train updates imitating benign parties. In this paper, we design a zero-knowledge untargeted attack (ZKA), which synthesizes malicious data to craft adversarial models without eavesdropping on the transmission of benign clients at all or requiring a large quantity of task-specific training data. To inject malicious input into the FL system by synthetic data, ZKA has two variants. ZKA-R generates adversarial ambiguous data by reversing engineering from the global models. To enable stealthiness, ZKA-G trains the local model on synthetic data from the generator that aims to synthesize images different from a randomly chosen class. Furthermore, we add a novel distance-based regularization term for both attacks to further enhance stealthiness. Experimental results on Fashion-MNIST and CIFAR-10 show that the ZKA achieves similar or even higher attack success rate than the state-of-the-art untargeted attacks against various defense mechanisms, namely more than 50% for Cifar-10 for all considered defense mechanisms. As expected, ZKA-G is better at circumventing defenses, even showing a defense pass rate of close to 90% when ZKA-R only achieves 70%. Higher data heterogeneity favours ZKA-R since detection becomes harder