Reversible Non-Volatile Electronic Switching in a Near Room Temperature van der Waals Ferromagnet

The ability to reversibly toggle between two distinct states in a non-volatile method is important for information storage applications. Such devices have been realized for phase-change materials, which utilizes local heating methods to toggle between a crystalline and an amorphous state with distinct electrical properties. To expand such kind of switching between two topologically distinct phases requires non-volatile switching between two crystalline phases with distinct symmetries. Here we report the observation of reversible and non-volatile switching between two stable and closely-related crystal structures with remarkably distinct electronic structures in the near room temperature van der Waals ferromagnet Fe$_{5-\delta}$GeTe$_2$. From a combination of characterization techniques we show that the switching is enabled by the ordering and disordering of an Fe site vacancy that results in distinct crystalline symmetries of the two phases that can be controlled by a thermal annealing and quenching method. Furthermore, from symmetry analysis as well as first principle calculations, we provide understanding of the key distinction in the observed electronic structures of the two phases: topological nodal lines compatible with the preserved global inversion symmetry in the site-disordered phase, and flat bands resulting from quantum destructive interference on a bipartite crystaline lattice formed by the presence of the site order as well as the lifting of the topological degeneracy due to the broken inversion symmetry in the site-ordered phase. Our work not only reveals a rich variety of quantum phases emergent in the metallic van der Waals ferromagnets due to the presence of site ordering, but also demonstrates the potential of these highly tunable two-dimensional magnets for memory and spintronics applications

Diagnosing and prognosticating the quality movement - a review on the 25 years quality literature (1987-2011)

The purpose of this article is to create a snapshot of 25 years quality movement. The creation process of the snapshot, as well as the result of the study, aims to help in diagnosing the current status of quality management (QM) and further contribute in understanding and shaping its future direction. For this purpose, all published articles during the last 25 years period (1987-2011) under the subject of Total Quality Management (TQM), Business Excellence (BE), quality tools, techniques as well as core values/principles have been collected through the ABI/INFORM complete periodical database. The collected data were analysed and reflected in order to show the current status, evolution trends of the past, and the predicted future directions. The results show that the total number of articles under the subject of TQM has been decreasing after having reached its peak in 1995. However, papers focusing on techniques and tools within the QM framework in terms of Lean, Just-in-Time/Toyota Production System, Benchmarking, and Six-Sigma Quality have been increasing. In addition, papers focusing on core values/key principles needed to build a quality culture in terms of leadership, people-based management, continuous improvements, management based on facts, and focus on the customer have been slightly increasing during the last decade. The findings indicate that QM is now at a more mature stage where focuses have shifted from being initially on TQM to tools, techniques, and core values which are needed for building a quality and BE culture. Based on its evolution, it is concluded that TQM can be understood as a management innovation, if not a management revolution

Diagnosing and prognosticating the quality movement - a review on the 25 years quality literature (1987-2011)

The purpose of this article is to create a snapshot of 25 years quality movement. The creation process of the snapshot, as well as the result of the study, aims to help in diagnosing the current status of quality management (QM) and further contribute in understanding and shaping its future direction. For this purpose, all published articles during the last 25 years period (1987-2011) under the subject of Total Quality Management (TQM), Business Excellence (BE), quality tools, techniques as well as core values/principles have been collected through the ABI/INFORM complete periodical database. The collected data were analysed and reflected in order to show the current status, evolution trends of the past, and the predicted future directions. The results show that the total number of articles under the subject of TQM has been decreasing after having reached its peak in 1995. However, papers focusing on techniques and tools within the QM framework in terms of Lean, Just-in-Time/Toyota Production System, Benchmarking, and Six-Sigma Quality have been increasing. In addition, papers focusing on core values/key principles needed to build a quality culture in terms of leadership, people-based management, continuous improvements, management based on facts, and focus on the customer have been slightly increasing during the last decade. The findings indicate that QM is now at a more mature stage where focuses have shifted from being initially on TQM to tools, techniques, and core values which are needed for building a quality and BE culture. Based on its evolution, it is concluded that TQM can be understood as a management innovation, if not a management revolution

Development of quality management in Taiwan the past, present and future

Quality management (QM) has been popular and widely used in Taiwan since the 1960s. However, it has been found that a review of its development is lacking. Hence, this paper aims to examine the history and the evolution of QM in Taiwan, and to take a step further to look for cues for shaping its future development. The research purpose of this paper is more specifically to review the development of QM during the period from 1970 to 2012. Quality Magazine, the most popular reading material on QM in Taiwan, has been selected as the search database. The overall review result shows that the development of QM in Taiwan has three developmental phases: (1) the quality technologies and tools focus period (1970-1985); (2) the QM system integration period (1986-2000) and (3) the quality in service industry development period (2001-2012). In light of the overall as well as the detailed review results, senior quality experts were invited for consultation, discussion and prediction of the needs and the future development of QM in Taiwan

Business excellence models : limitations, reflections and further development

The use of business excellence models (BEM) has become popular in the last two decades, and several companies have learned how to use them and gained from such models. More companies, we assume, have experienced problems when using such models because of various weaknesses such as too-sophisticated assessment criteria, excessive paperwork, cumbersome procedures and a lack of focus, which have limited its use in practice. To respond to some of those problems, a new overall business excellence framework (BEF) has been developed which recommends adaption instead of adoption of existing BEM. The suggested overall BEF helps to integrate BEM with management tools/techniques and the organisational culture/characteristics for guiding an organisation towards business excellence. A document-based empirical case of a world-class company, Boeing Aerospace Support, was investigated to illustrate how the overall BEF may work in practice as a complement to an existing BEM when companies adapt such models to their specific contexts

Severe Hypoglycemia as a Predictor of End-Stage Renal Disease in Type 2 Diabetes: A National Cohort Study

Aims: This study investigated whether there is a link between severe hypoglycemia and progression into end-stage renal disease (ESRD) in patients with type 2 diabetes. Methods: Tapping into Taiwan’s Health Insurance Research Database, we identified all type 2 diabetes patients between 1996 and 2013 and identified those diagnosed with a severe hypoglycemia episode during an emergency department visit and those who were not. Controls were then matched 1:1 for age, sex, index year, and medication. Results: We identified 468,421 type 2 diabetes patients diagnosed as having severe hypoglycemia in an emergency department visit. Compared with controls, these patients with SH had a higher risk of all-cause mortality (Hazard Ratio (HR), 1.76; 95% confidence interval, 1.61⁻1.94) and progressed into ESRD within a shorter period of time. Results were similar after controlling for competing risk. Conclusion: Severe hypoglycemia is significantly associated with worsening renal dysfunction in patients with type 2 diabetes and hastened progression into ESRD

Hazard Assessment of Typhoon-Driven Storm Waves in the Nearshore Waters of Taiwan

In Taiwan, the coastal hazard from typhoon-induced storm waves poses a greater threat to human life and infrastructure than storm surges. Therefore, there has been increased interest in assessing the storm wave hazard levels for the nearshore waters of Taiwan. This study hindcasted the significant wave heights (SWHs) of 124 historical typhoon events from 1978 to 2017 using a fully coupled model and hybrid wind fields (a combination of the parametric typhoon model and reanalysis products). The maximum SWHs of each typhoon category were extracted to create individual storm wave hazard maps for the sea areas of the coastal zones (SACZs) in Taiwan. Each map was classified into five hazard levels (I to V) and used to generate a comprehensive storm wave hazard map. The results demonstrate that the northern and eastern nearshore waters of Taiwan are threatened by a hazard level IV (SWHs ranging from 9.0 to 12.0 m) over a SACZ of 510.0 km2 and a hazard level V (SWHs exceeding 12.0 m) over a SACZ of 2152.3 km2. The SACZs threatened by hazard levels I (SWHs less than 3.0 m), II (SWHs ranging from 3.0 to 6.0 m), and III (SWHs ranging from 6.0–9.0 m) are of 1045.2 km2, 1793.9 km2, and 616.1 km2, respectively, and are located in the western waters of Taiwan

Valproic acid exerts an anti-tumor effect on tongue cancer sas cells in vitro and in vivo

Background: Valproic acid (VPA) is a drug approved by the Food and Drug Administration for epilepsy and bipolar disorders. It is also a known histone deacetylase inhibitor and has been evaluated as an anti-cancer agent. However, the in vitro and in vivo anti-tumor effect of VPA on human tongue cancer has not been evaluated. Materials and Methods: We tested VPA for its anti-tumor activity on the human tongue cancer (SAS) cell line in vitro and in vivo in a tumor xenograft model in mice. The effect of VPA on the cell cycle and apoptosis was examined. Results: Growth inhibition was noted when SAS, squamous cell carcinoma 25 and OECM-1 cells were treated with various doses of VPA for 24-72 h, and it was found that VPA treatment caused G1 arrest and apoptosis in SAS cells. VPA also inhibited the phosphorylation of Akt and ERK in SAS cells in vitro. Tumor growth inhibition was observed in NOD/SCID mice bearing xenografts of human tongue cancer that were treated with a VPA dose of 400 mg/kg/day. Conclusions: This study demonstrates that VPA can inhibit the growth of human tongue cancer cells in vitro and in vivo without causing any significant adverse effects