Oxidative coupling of thiols to disulphides

819-82

LAH induced stereoselective dehalogenation of vicinal-dihalides via single electron transfer

910-91

Nickel boride mediated chemoselective deprotection of 1,1-diacetates to aldehydes and deprotection with concomitant reduction to alcohols at ambient temperature

<p>A variety of 1,1-diacetates have been chemoselectively and efficiently deprotected to the corresponding aldehydes as well as deprotected and concomitantly reduced to the corresponding alcohols in high yields at ambient temperature with nickel boride generated <i>in situ</i> using different molar ratios of sodium borohydride and nickel (II) chloride in methanol at room temperature. Deprotection and reduction of a variety of aromatic, aliphatic and heterocyclic acylals have been achieved efficiently. Mild reaction conditions, easy work-up, high yields and chemoselectivity demonstrate the efficiency of this new method.</p

Lanthanum Triflate–Catalyzed Rapid Oxidation of Secondary Alcohols Using Hydrogen Peroxide Urea Adduct (UHP) in Ionic Liquid

<div><p></p><p>A convenient and efficient protocol for the oxidation of secondary hydroxyl group to ketone using hydrogen peroxide–urea adduct and catalytic (CF₃SO₃)₃La in ionic liquid has been developed. A number of 1,2-diols, α-hydroxyketones, and other aromatic and aliphatic secondary alcohols have been successfully oxidized to the corresponding ketones using this protocol in good yields and short reaction times.</p> <p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Synthetic Communications</i>® for the following free supplemental resource(s): Full experimental and spectral details.]</p> </div

Efficient catalyst-free synthesis of diversified bis (spirooxindoles) via one-pot, three-component reaction

<p>A catalyst-free, one-pot synthesis of bis-spirooxindoles has been carried out by a three-component reaction of bis-isatins, malononitrile, and various cyclic enolizable carbonyl compounds in ethylene glycol at 100 °C. The protocol provides an easy and simple route for the synthesis of such complex compounds, in short reaction times and high yields. No chromatographic techniques have been employed for the purification of the compounds.</p