A variation of a classical Turán-type extremal problem

AbstractA variation of a classical Turán-type extremal problem (Erdős on Graphs: His Legacy of Unsolved Problems (1998) p. 36) is considered as follows: determine the smallest even integer σ(Kr,s,n) such that every n-term graphic non-increasing sequence π=(d1,d2,…,dn) with term sum σ(π)=d1+d2+⋯+dn≥σ(Kr,s,n) has a realization G containing Kr,s as a subgraph, where Kr,s is a r×s complete bipartite graph. In this paper, we determine σ(Kr,s,n) exactly for every fixed s≥r≥3 when n≥n0(r,s), where m=[(r+s+1)24] andn0(r,s)=m+3s2−2s−6,ifs≤2randsis even,m+3s2+2s−8,ifs≤2randsis odd,m+2s2+(2r−6)s+4r−8,ifs≥2r+1

Evaluating free flux flow in low-pinning molybdenum-germanium superconducting films

Vortex dynamics in molybdenum-germanium superconducting films were found to well approximate the unpinned free limit even at low driving forces. This provided an opportunity to empirically establish the intrinsic character of free flux flow and to test in detail the validity of theories for this regime beyond the Bardeen-Stephen approximation. Our observations are in good agreement with the mean-field result of time dependent Ginzburg-Landau theory. PACS: 74.25.Sv,74.25.Wx,74.25.Uv,74.25.Op,74.25.F- Keywords: vortices, fluxon, Larkin, Ovchinnikov, upper critical magnetic fieldComment: This is the final revised version of a paper that is currently in press. It is expected to appear in Phys. Rev. B in 201

Contribution of Gray and White Matter Abnormalities to Cognitive Impairment in Multiple Sclerosis

Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance imaging (MRI) techniques to evaluate differences in white matter (WM) integrity and gray matter (GM) volume between MS patients with CI and MS patients with cognitive preservation (CP). Neuropsychological assessment and MRI were obtained from 39 relapsing-remitting MS (RRMS) patients and 29 healthy controls (HCs). Patients were classified as CI or CP according to cognitive ability, and demographic characteristics and MRI images were compared. Compared with HCs, MS patients exhibited widespread damage in WM integrity, and GM loss in several regions. Compared with CP patients, CI patients exhibited more extensive WM impairments, particularly in the corpus callosum, cerebellar peduncle, corona radiata, optic radiation, superior longitudinal fasciculus, anterior limb of the internal capsule, and cingulate, as well as decreased GM volume in the bilateral caudate, left insula and right temporal lobe. MS patients with CI exhibited more significant structural abnormalities than those with CP. Widespread impairments of WM integrity and selective GM atrophy both appear to be associated with impaired cognition in RRMS

A simple way to fine tune the redox potentials of cobalt ions encapsulated in nitrogen doped graphene molecular catalysts for the oxygen evolution reaction

Co2+ ions encapsulated in nitrogen doped graphene were applied as an oxygen evolution catalyst. Their redox potentials were tuned using different counter anions as liable ligands, and the redox potential related catalytic rates were explored. It was proposed that the electron density of Co2+ ions was a general descriptor for activity

Summary of 615 patients of chronic myeloid leukemia in Shanghai from 2001 to 2006

<p>Abstract</p> <p>Background</p> <p>To retrospectively review the incidence, treatment efficacy, we followed up newly diagnosed chronic myelogenous leukemia (CML) patients residing in Shanghai during 2001-2006.</p> <p>Methods</p> <p>All eligible cases were reviewed with the data of efficacy responses as well as overall survival (OS) and progression-free survival (PFS) time.</p> <p>Results</p> <p>A total of 615 cases entered the study. CML mainly afflicted those aged 40-60 years old and was slightly more frequent in males than females. More than 85% of the patients were in chronic phase (CP) when diagnosed. All patients were divided into four groups based on the main regimens - hydroxyurea, interferon alpha (IFN-α), imatinib, and hemopoietic stem cell transplantation (HSCT). With the median follow-up of 18 months, imatinib treatment induced 92.2% complete hematologic responses, and 64.3% complete cytogenetic responses among CML-CP patients. Overall the therapeutic efficacy in the imatinib group was higher than that in the hydroxyurea or IFN-α group. Meanwhile, in the imatinib group, all response rates of patients in CP were significantly greater than that in accelerated or blastic crisis phase. The patients treated with imatinib also showed the most promising results regarding OS and PFS. Patients receiving HSCT decreased markedly in number with the introduction of imatinib.</p> <p>Conclusions</p> <p>The number of new patients arising in Shanghai increased from 2001 to 2006. There were still patients receiving hydroxyurea and IFN-α. As the first-line regime for CML, imatinib was less administered in Shanghai before, but has received considerable development and great responses since 2003.</p

mRNA Expression of Ovine Angiopoietin-like Protein 4 Gene in Adipose Tissues

Angiopoietin-like protein 4 (ANGPTL4) is involved in a variety of functions, including lipoprotein metabolism and angiogenesis. To reveal the role of ANGPTL4 in fat metabolism of sheep, ovine ANGPTL4 mRNA expression was analyzed in seven adipose tissues from two breeds with distinct tail types. Forty-eight animals with the gender ratio of 1:1 for both Guangling Large Tailed (GLT) and Small Tailed Han (STH) sheep were slaughtered at 2, 4, 6, 8, 10, and 12 months of age, respectively. Adipose tissues were collected from greater and lesser omental, subcutaneous, retroperitoneal, perirenal, mesenteric, and tail fats. Ontogenetic mRNA expression of ANGPTL4 in these adipose tissues from GTL and STH was studied by quantitative real time polymerase chain reaction. The results showed that ANGPTL4 mRNA expressed in all adipose tissues studied with the highest in subcutaneous and the lowest in mesenteric fat depots. Months of age, tissue and breed are the main factors that significantly influence the mRNA expression. These results provide new insights into ovine ANGPTL4 gene expression and clues for its function mechanism

Association of Maternal Autoimmune Diseases With Risk of Mental Disorders in Offspring in Denmark

IMPORTANCE Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring during childhood, but little is known about how maternal autoimmune diseases during pregnancy are associated with mental health in offspring during and after childhood.OBJECTIVE To investigate the association between maternal autoimmune diseases before childbirth and risk of mental disorders among offspring up to early adulthood.DESIGN, SETTING, AND PARTICIPANTS This population-based nationwide cohort study used data from Danish national registers on singletons born in Denmark from 1978 to 2015 with up to 38 years of follow-up. Data analyses were conducted from March 1, 2020, through September 30, 2021.EXPOSURES Maternal autoimmune disease diagnosed before or during pregnancy according to the Danish National Patient Register.MAIN OUTCOMES AND MEASURES The main outcome was mental disorders, defined by hospital diagnoses, in offspring. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for mental disorders.RESULTS Of the 2 254 234 singleton infants included in the study (median age, 16.7 years [IQR, 10.5-21.7 years]; 51.28% male), 2.26% were born to mothers with autoimmune diseases before childbirth. Exposed participants had an increased risk of overall mental disorders compared with their unexposed counterparts (HR, 1.16; 95% CI, 1.13-1.19; incidence, 9.38 vs 7.91 per 1000 person-years). Increased risks of overall mental disorders in offspring were seen in different age groups for type 1 diabetes (1-5 years: HR, 1.35 [95% CI, 1.17-1.57]; 6-18 years: HR, 1.24 [95% CI, 1.15-1.33]; >18 years: HR, 1.19 [95% CI, 1.09-1.30]) and rheumatoid arthritis (1-5 years: HR, 1.42 [95% CI, 1.16-1.74]; 6-18 years: HR, 1.19 [95% CI, 1.05436]; >18 years: HR, 1.28 [95% CI, 1.02-1.60]). Regarding specific mental disorders, increased risk after exposure to any maternal autoimmune disorder was observed for organic disorders (HR, 1.54; 95% CI, 1.21-1.94), schizophrenia (HR, 1.35; 95% CI, 1.21-1.51), obsessive-compulsive disorder (HR, 1.42; 95% CI, 1.24-1.63), mood disorders (HR, 1.12; 95% CI, 1.04-121), and a series of neurodevelopmental disorders (eg, childhood autism [HR, 1.21; 95% CI, 1.08436] and attention-deficit/hyperactivity disorder [HR, 1.19; 95% CI, 1.12-1.26]).CONCLUSIONS AND RELEVANCE In this cohort study in Denmark, prenatal exposure to maternal autoimmune diseases was associated with increased risks of overall and type-specific mental disorders in offspring. Maternal type 1 diabetes and rheumatoid arthritis during pregnancy were associated with offspring's mental health up to early adulthood. Individuals prenatally exposed to autoimmune disease may benefit from long-term surveillance for mental disorders.</p

Association of Maternal Autoimmune Diseases with Risk of Mental Disorders in Offspring in Denmark

Funding Information: László); grants 19410713500 and 2018SHZDZX01 from the Science and Technology Commission of Shanghai Municipality (Dr F. Li); grants GWV-10.1-XK07, 2020CXJQ01, and 2018YJRC03 from the Shanghai Municipal Commission of Health and Family Planning (Dr F Li); and grant 2018B030335001 from the Guangdong Key Project (Dr F Li) . Funding Information: Funding/Support: This study was supported by grant NNF18OC0052029 from the Novo Nordisk Foundation (Dr J. Li) ; grants DFF-6110-00019B, DFF-9039-00010B, and DFF-1030-00012B from the Danish Council for Independent Research (Dr J. Li); grant R275-A15770 from the Nordic Cancer Union (Dr J. Li); grant 2016 from the Karen Elise Jensens Fond (Dr J. Li); grants 81761128035, 81930095, and 82125032 (Dr F. Li) and grant 82073570 (Dr J. Li) from the National Natural Science Foundation of China; grant 20180306 from the Swedish Heart and Lung Foundation (Dr László); grant 2015-00837 from the Swedish Council for Working Life and Social Research (Dr Publisher Copyright: © 2022 American Medical Association. All rights reserved.Importance: Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring during childhood, but little is known about how maternal autoimmune diseases during pregnancy are associated with mental health in offspring during and after childhood. Objective: To investigate the association between maternal autoimmune diseases before childbirth and risk of mental disorders among offspring up to early adulthood. Design, Setting, and Participants: This population-based nationwide cohort study used data from Danish national registers on singletons born in Denmark from 1978 to 2015 with up to 38 years of follow-up. Data analyses were conducted from March 1, 2020, through September 30, 2021. Exposures: Maternal autoimmune disease diagnosed before or during pregnancy according to the Danish National Patient Register. Main Outcomes and Measures: The main outcome was mental disorders, defined by hospital diagnoses, in offspring. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for mental disorders. Results: Of the 2254234 singleton infants included in the study (median age, 16.7 years [IQR, 10.5-21.7 years]; 51.28% male), 2.26% were born to mothers with autoimmune diseases before childbirth. Exposed participants had an increased risk of overall mental disorders compared with their unexposed counterparts (HR, 1.16; 95% CI, 1.13-1.19; incidence, 9.38 vs 7.91 per 1000 person-years). Increased risks of overall mental disorders in offspring were seen in different age groups for type 1 diabetes (1-5 years: HR, 1.35 [95% CI, 1.17-1.57]; 6-18 years: HR, 1.24 [95% CI, 1.15-1.33]; >18 years: HR, 1.19 [95% CI, 1.09-1.30]) and rheumatoid arthritis (1-5 years: HR, 1.42 [95% CI, 1.16-1.74]; 6-18 years: HR, 1.19 [95% CI, 1.05-1.36]; >18 years: HR, 1.28 [95% CI, 1.02-1.60]). Regarding specific mental disorders, increased risk after exposure to any maternal autoimmune disorder was observed for organic disorders (HR, 1.54; 95% CI, 1.21-1.94), schizophrenia (HR, 1.35; 95% CI, 1.21-1.51), obsessive-compulsive disorder (HR, 1.42; 95% CI, 1.24-1.63), mood disorders (HR, 1.12; 95% CI, 1.04-1.21), and a series of neurodevelopmental disorders (eg, childhood autism [HR, 1.21; 95% CI, 1.08-1.36] and attention-deficit/hyperactivity disorder [HR, 1.19; 95% CI, 1.12-1.26]). Conclusions and Relevance: In this cohort study in Denmark, prenatal exposure to maternal autoimmune diseases was associated with increased risks of overall and type-specific mental disorders in offspring. Maternal type 1 diabetes and rheumatoid arthritis during pregnancy were associated with offspring's mental health up to early adulthood. Individuals prenatally exposed to autoimmune disease may benefit from long-term surveillance for mental disorders.Peer reviewe